Category: children

bookmark_borderClimate Change: The End of Times

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by Daniel Brouse
July 21, 2023

What will the “End of Times” look like?

In the 1990’s, we wrote a paper on the worst-case scenario entitled, “The Impact of Governance & Globalization on Forecasting (The Tunnel Under Thesis).” The theory predicted that forecasting would become increasing difficult. “The result — a figurative, as well as, literal tunneling underground.”

Since that time, forecasting has become increasing more difficult. “In general, as energy is added to a system, the fluctuations in the system increase. So, we expect more storms, more droughts, more wildfires, more floods, more fluctuations of all kinds. What we are saying is that weather conditions will become more volatile due to the impact of humans,” said Mukherjee and Brouse. (2004)

In a report published in Nature entitled Over half of known human pathogenic diseases can be aggravated by climate change, data analyst and associate professor in the Department of Geography and Environment at the University of Hawaii Manoa, Camilo Mora, said climate hazards aggravated 58% of all known human pathogens. That is over half of infectious diseases discovered since the end of the Roman Empire. 58% of an authoritative list of infectious diseases documented to have impacted humanity have already been shown to be aggravated by climatic hazards — a finding the researchers found “shocking,” Mora said.

Movement of people and animals caused by climate is one factor. Warming at higher latitudes allowed vectors and pathogens to survive winter is another factor. The report goes on to say, “The human pathogenic diseases and transmission pathways aggravated by climatic hazards are too numerous for comprehensive societal adaptations, highlighting the urgent need to work at the source of the problem: reducing GHG (Greenhouse Gas) emissions.”

This research reveals more evidence that humans will have difficulty adapting to climate change, especially those in developing countries, Mora said. “The magnitude of the vulnerability when you think about one or two diseases — okay, sure, we can deal with that,” he said. “But when you’re talking about 58% of the diseases, and 58% of those diseases can be affected or triggered in 1,000 different ways. So that, to me, was also revealing of the fact that we’re not going to be able to adapt to climate change.”

In 2023, I wrote the paper, “Climate Change: How Long Is ‘Ever’?“. When we wrote the Tunnel Under Thesis, we forecast these events would not happen for centuries. We underestimated Man’s ignorance and arrogance. Fossil fuel consumption and greenhouse gas emissions have continued to set record highs. Humans have caused chain-reactions resulting in domino-effects, snowball effects, and feedback loops.

Events we thought would not happen in our lifetimes are happening now. My last resort emergency plan was to escape to Canada. (I am a dual citizen.) This summer that plan literally went up in smoke. “Beginning in March 2023, and with increased intensity starting in June, Canada has been affected by an ongoing, record-setting series of wildfires.” — Wikipedia

All of my life I have located my office and bedrooms in the uppermost southern exposure (preferably in the tree canopy.) I love sunlight, elevation, trees, fresh air, and wildlife. It is becoming ever more obvious my dreamlife is coming to an end, and I will be forced to tunnel under. For those forward thinkers, think about your poop. Pumping sewage above ground level will be a major problem at all times. In addition, the inability to pump flood water will become deadly during extreme weather events. In July of 2020 NPR reported, “The remnants of Hurricane Ida dropped unprecedented rainfall on several eastern states, killing dozens of people. Eleven of them were Queens residents who died when their basement apartments flooded.” In August of 2022 CNN reported, “Seoul has vowed to move some of the city’s poorest families out of underground and semi-subterranean homes after 13 people were killed in flooding caused by record rainfall this week, sparking public horror and calls for government accountability.” Drowning in your own poop may result for those unprepared.

Fresh air, water, food, and light will also be problematic; however, your most severe concern will likely be security. Those with supplies will be at high risk of being raped and looted. Good luck!

More From the Human Induced Climate Change Experiment

bookmark_borderHealth Impacts of Air Pollution

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By Daniel Brouse
June 30, 2023

The health impacts of air pollution are both cumulative and irreversible. The more polluted the air, the more severe the effects. The more polluted air you breathe over time, the more severe the effects. That is to say breathing “Moderate” quality air for 3 days might be similar to breathing “Unhealthy for Sensitive Group” quality air for 1 day. In both cases, your respiratory, circulatory, neurological, and immune systems have been damaged. A partial list of ailments include:
Alzheimer’s Disease, asthma, bronchitis, cancer, cataracts, chronic obstructive pulmonary disease (COPD), dementia, developmental damage, emphysema, gastrointestinal disorders, heart ailments, heart attacks, immune system dysfunction (including susceptibility to infections), ischaemic heart disease, impaired brain development in children, kidney disease, liver disease, lung disease, premature death, pneumonia, nasal and upper respiratory tract health problems, neurological disorders, respiratory system failure, skin diseases, strokes

You can (and should) check your local air quality several times a day at AirNow.gov. The air quality index (AQI) goes from 0 to 500. An AQI value of 50 or below represents good air quality, while an AQI value over 300 represents hazardous air quality.

EPA establishes an AQI for five major air pollutants regulated by the Clean Air Act. Each of these pollutants has a national air quality standard set by EPA to protect public health:

  • ground-level ozone
  • particle pollution (also known as particulate matter, including PM2.5 and PM10)
  • carbon monoxide
  • sulfur dioxide
  • nitrogen dioxide

Following is an explanation of two of these pollutants — particle pollution and ground-level ozone.

Particulate Matter (PM)

The EPA defines particulate matter (also called particle pollution): the term for a mixture of solid particles and liquid droplets found in the air. Some particles, such as dust, dirt, soot, or smoke, are large or dark enough to be seen with the naked eye. Others are so small they can only be detected using an electron microscope.

Particle pollution is similar to smoking cigarettes. The more you inhale, the worse it is for you. Also, the more particles in the air you breath, the worse it is for you. Breathing air on a day with an AQI that is unhealthy is similar to smoking a half-pack of cigarettes. If you go running instead of walking, it might be equivalent to smoking 2 packs of cigarettes.

The more particulate matter you breathe in over time, the greater the cumulative effect. The impact on your health will depend on your predisposition. In all cases your risk increases for nasal and upper respiratory tract health problems, heart attacks, strokes, asthma, and bronchitis, as well as premature death from heart ailments, lung disease, and cancer. Studies show that exposure can impair brain development in children and are significantly associated with the development of dementia and Alzheimer’s disease.

Some of the impacts of particle pollution may be reversed overtime if further exposure to particle pollution is eliminated. After five years of quitting smoking, the risk of developing complications decreases by up to 50%.

The best lifestyle is to avoid particulate matter. Exercise outside only on days with a “Good” AQI under 50. If you must go out on days with an AQI over 50, wear an N95 mask. Indoors build and run a Corsi-Rosenthal Box filter.

Ground-level Ozone

Tropospheric ozone is low level ozone caused by humans. Tropospheric ozone is “bad ozone” that causes health problems in humans, plants to die and other destructive results. (Stratospheric ozone, the good ozone, is the ozone layer in the stratosphere that keeps 95-99% of the suns ultraviolet radiation from striking the earth.)

“Tropospheric ozone is formed by the interaction of sunlight, particularly ultraviolet light, with hydrocarbons and nitrogen oxides, which are emitted by automobiles, gasoline vapors, fossil fuel power plants, refineries, and certain other industries.” — National Center for Atmospheric Research

Ozone primarily affects the respiratory and immune systems. The damage is permanent, untreatable and often results in death. The Santa Barbara County Air Pollution Control District reports, “Roughly one out of three people in the U.S. is at risk of experiencing ozone-related health effects.”

The best lifestyle is to avoid ozone exposure. Since heat and ultraviolet light are needed to create ozone, staying indoors offers the best protection. Neither masks nor air purifiers protect from ozone exposure. (Ozone is O3 and almost the same size as Oxygen O2)

REFERENCES
Death by Ozone
COVID-19 and Air Pollution
Ozone Know Zone
Air Pollution Kills
Indoor Air Pollution: How to Purify the Air, Aromatic Plants, and Phytoncides
Corsi-Rosenthal Box filter
The Human Induced Climate Change Experiment

bookmark_borderCorsi-Rosenthal Box: The Best Air Purifier

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What is a Corsi-Rosenthal Box and how do you build one? The Corsi-Rosenthal Box is a simple DIY air filter and purifier that outperforms and can be more effective than expensive HEPA purifiers.

Corsi-Rosenthal Boxes are made from cardboard, tape, furnace air filters, and a box fan.

Corsi-Rosenthal Box
Corsi-Rosenthal Box

The Corsi-Rosenthal Box was invented by Richard Corsi, PhD, of the University of California-Davis and Jim Rosenthal, CEO of Tex-Air Filters.

“One night, I just scribbled out this idea on a piece of paper,” said Corsi. “It wasn’t an original idea – people had put a single filter on a box fan before. But not with MERV 13 filters.” (MERV — minimum efficiency reporting values — is the measure of how well a filter captures particles. The higher the MERV, the more effective the filter.)

“The Corsi-Rosenthal box outperformed the HEPA filter on every sized particle,” Rosenthal said. “You have such high flow from these fans, way more flow than you get out of a commercial HEPA filter. The air goes through the filter more than once in the same period of time. It may only get 50% of the particles at first. But the second time through, it’s getting much more.”

Corsi-Rosenthal Box Test

Smoke from wildfires in Canada brought record-breaking air pollution to the United States this spring, creating dangerous air quality from Bismarck, N.D., to Denver and Detroit to New York City and Washington. According to a Washington Post analysis of smoke data through June 7 (2023) from Stanford University, 197 air quality monitoring stations have reported all-time high pollution from wildfires.

During the Air Quality Crisis of 2023 the plant-based long-term breathing experiment failed the test. After 4 days in a row of Unhealthy (151 to 200 AQI) to Hazardous (301 and higher AQI) outdoor air quality, the the plant-filtered indoor air quality was unhealthy.

Even with spider plant filled windows and dozens of other plants, humans still suffered from itchy eyes, scratchy throats, and headaches.

Christopher suggested, “You should look into Corsi-Rosenthal… they consistently outperform high-end air filtration systems and it’s a simple DIY project.”

Sidd independently advised, “We are way beyond that (plant filtration). Put in something about Corsi-Rosenthal filters and CO2 monitors to judge ventilation.

Sooo… luckily I had a couple furnace filters, a box fan, and a case of beer. After constructing a crude Corsi-Rosenthal Box, the entire first floor was cleared of noticeable pollutants within 15 minutes. The itchy eyes, scratchy throat, and headache dissipated.

Makeshift / Emergency Corsi-Rosenthal Box
Makeshift / Emergency Corsi-Rosenthal Box

To confirm our results, we brought in the hound dog. Dogs are even more sensitive to air quality. After days of suffering in unhealthy air quality, the hound immediately laid down with his nose in the flow of the circulating Corsi-Rosenthal filtered air.

Conclusion
Air quality is already considered the number one contributing factor to death worldwide. Climate change is making poor air quality even more extreme. A combination of plant and Corsi-Rosenthal filtered air is recommended on a daily basis.

Our experiment was conducted in Southeastern Pennsylvania during an extreme air quality event; however, to our east is Philadelphia. The immediate Philadelphia area rarely has a day of Good air quality. Most summer days are Moderate to Very Unhealthy. To our west is Morgantown and Lancaster County. Even though Lancaster is a much more rural area, it continuously has some of the worst air quality in the world. So it doesn’t really matter where you live, implementing plant and Corsi-Rosenthal filtered air to the daily routine will likely improve your quality and quantity of life.

More on Clean Water, Air, and Healthy Plants
More Things You Can Do to Help the Environment and Your Health

 

bookmark_borderGood Gut Bacteria and Food Allergies

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The rise in food allergies has nothing to do with GMOs. The increase number of people with fool allergies is mostly to do with good gut bacteria. Many children are not getting introduced to the bacteria needed to establish good gut bacteria. Many adults good gut bacteria is getting destroyed by diseases, such as, COVID. Reestablishing good gut bacteria is difficult. For instance, one of these bacteria can only be found in milk or meat from cud chewing bovine. There are an estimated 100 trillion “good” bacteria.

bookmark_borderAir Pollution: the Baby Killer

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Air pollution, both inside and outside the home, contributed to the deaths of about 500,000 newborns in 2019, as reported in the State of Global Air 2020. State Of Global Air 2020 PDF

“The number is just staggering,” reports the epidemiologist that led the stufy, Rakesh Ghosh of the University of California, San Francisco. The study suggests air pollution contributes to about 20% of infant deaths.

“I think you can easily dismiss this finding as something that only happens to people who live far away in thatched roof houses and not to us,” says Niermeyer, a professor at the University of Colorado Medicine. “But air pollution effects our babies, as well.”

bookmark_borderCOVID, Tryptophan, Stress, Anxiety, and Pellagra

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by Daniel Brouse

NAD+ is a crucial part of the immune and neurological systems. COVID depletes your NAD+. The body needs the time and materials necessary to replenish NAD+. Included in the elements you need are Vitamins C, B3 (Niacin), D, Quercetin, Zinc, and Selenium.

In their paper, COVID-19: NAD+ deficiency, Robert Miller and Ade Wentzel explain the role of NAD+ in the severity of COVID-19 and the depletion of niacin and tryptophan.

I asked Robert Miller, “Is the NAD+ depletion what causes the tryptophan shortage?”

Robert replied, “Post Covid-19 is CISP (Covid Induced Secondary Pellagra) which causes the body to divert tryptophan to NAD+ production at the expense of Serotonin, Oxytocin, Endorphins and Dopamine. In the case of pre Covid-19 it’s the conditions that drive up CD38, oxidative stress, and continual hyperglycemic events and undiagnosed subclinical pellagra (hard to diagnose) which all reduce NAD+. Basically our diet and lifestyle set us up for Covid-19 and can’t save us post Covid-19.”

Ade said, “The anxiety is because the body is using all the tryptophan to make NAD+.”

COVID depletes your NAD+. The body depletes tryptophan trying to make NAD+. This causes post-COVID anxiety. You can treat CISP and post-COVID anxiety with niacin.

B3 Deficiency and Anxiety Disorders
The anxiety disorder caused by COVID-19 is also related to undiagnosed subclinical pellagra. Most Americans have a niacin (Vitamin B3) deficiency before they contract COVID. Though the virus may make the niacin deficiency more obvious, many non-COVID related anxiety disorders can also be treated with niacin.

In the US, the largest source of niacin in most diets is from fortified breakfast cereal. They spray vitamins, including Niacin, on the outside surface of the cereal. You would need to eat 100 bowls of Wheaties a day to make-up for a niacin deficiency (not recommended).

Stress uses up NAD+, depleting the tryptophan further, thus compounding the feeling of anxiety. The main ingredient of Nicotinamide adenine dinucleotide (NAD+) is niacin. The best method for treating anxiety caused by depleted NAD+ and tryptophan is to replenish the niacin.

Robert and Ade explain to me how to supplement my niacin and create NAD+ — COVID, Vitamin B3, and the Immune System.

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

bookmark_borderCOVID: Treatment?

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By Daniel Brouse

COVID
COVID

This is an interview with Ade Wentzel. Ade is a doctor and scientist working with COVID hospitals. I met Ade in a COVID survivors group. Though I did not know it at the time, I survived COVID in February of 2020. It was only months later that I figured out something was wrong with me. Even though I had been isolating since February, I kept getting sick. After a month of scientific research, I was diagnosed with Long Haulers Syndrome.

I had come to the conclusion that my long haulers was caused by lots of little cytokine storms. During a heated debate with a COVID antigen scientist from Spain that is researching for Johns Hopkins, Ade joined the conversation. The Johns Hopkins scientist took issue with the words “cytokine storms”. A cytokine storm is defined as a single large event. Ade helped me come to the conclusion that I was having cytokine disfunctions.

We do know that the virus consumes NAD+ because various studies have measured it. We do know that NAD+ and zinc are needed for SIRT1 activation. We also know that SIRT 1 downregulates TACE and hence downregulates TNFa and hence IL6.

Possibly for the longhaulers it’s cytokine imbalance or just NAD+ deficiency. The symptomatology improves vastly with NAD+ precursors but if cellular damage or organ damage is to occur, this takes time.

I do agree the term cytokine storm for long haulers is very incorrect, but an autoimmune disconnect seems more appropriate.
— Ade Wentzel

Ade referred me to a research paper: COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity. It took me several months to figure out that Ade is a co-author of the research. During this time, I embraced “Ade’s Protocol”: Vitamin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium.

INTERVIEW WITH ADE
Do you think you are cured of your long haulers? Do you think it is likely you may have other long term damage that you are not yet aware of?
Ade: So I am probably one of the longest around 6 Dec 2019 and am 99.5% back to normal.

We set out to investigate how to do the above, change risk, and of the about 3500 on a prophylactic regime only 1 person has been positive and had multiple exposures running a covid hospital. His course proved to be mild.

As a clinician I am super scared of such anecdotal evidence and a trial is really the only way to gain exposure and traction.

Am I worried about long term damage that I may not be aware of? No…if it raises its head I will deal with it then.

We never set out to chase the virus, but only to save 1 person….and that we have done. It’s been a team approach with Robert Miller
who first noticed the NAD+ link and Prof Guy A. Richard’s who guided, scrutinized, questioned and encouraged the clinical process.

In my humble opinion, you guys should get the Nobel Prize. I knew the protocol was working on my long haulers, but wasn’t sure if you thought it was a prophylactic, too. And, I’m guessing it might also be a “treatment” for active COVID cases?
Ade: it works wonders for all 3. Pre, during and after and for post covid anxiety.We started with pre covid prophylaxis on a small 250 strong group in Ireland who were then starting to peak and at 3 care centers in the UK all on a voluntary basis. Then, progressed to acute patients. Through this process I was a long hauler who had access to all specialties to discuss our research and often going on to treat them when they became unwell.

COVID NAD+ Deficiency

COVID-19 Index

bookmark_borderCOVID, Vitamin B3 (Nicotinic Acid), and the Immune System

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By Daniel Brouse

Vitamin B3 / Niacin / Nicotinic Acid

Attn: Long Haulers focus on supplementing with nicotinic acid.

A research paper co-authored by Ade Wentzel found, “The SARS-CoV-2 hyperinflammatory response is associated with high mortality.” In essence, COVID-19 ‘eats’ the immune system’s NAD+ (nicotinamide adenine dinucleotide) and restricts your ability to make more.  NAD+ is one of the most critical pieces to your immune system puzzle. A deficiency in NAD+ needs to be corrected over time by allowing the body to produce a new supply of NAD+. Nicotinic acid can help reduce the severity of COVID-19, as well as, treat long-COVID long haulers syndrome. Nicotinic acid is also the most important supplement to prevent aging, hypertension, type II diabetes, and obesity NAD+ deficiencies.

NAD+ is nicotinamide adenine dinucleotide. The formula to create NAD+ is complicated (see diagram below). The simplest way to explain it is: add Vitamin B3 Niacin (nicotinic acid) to your diet. Ade suggests, ‘You can take nicotinic acid orally or niagen (if you have deep pockets). However you supplement, you need to keep going for at least a good few months.”

Ade added, “I’d rather use nicotinic acid and not nicotinamide, as the latter can be a SIRT1 inhibitor.
Nicotinic acid is also probably the most direct way to save tryptophan.
There is no need to limit nicotinic acid to 35mg.
It has been used in lipid trials up to 3000mg a day (44mg/kg body weight)”

I have to take 150mg of nicotinic acid with each meal (3 times per day) to treat my long-COVID “long haulers syndrome”. To save money, I buy 500mg tablets and break them into pieces. It costs me about 3 cents per day to treat my NAD+ deficiency.

“When you dig down deep enough it’s amazing how often you end up at NAD+,” added Robert Miller, another co-author of COVID-19: NAD+ deficiency.

Vitamin B3 / niacin is the most crucial component for creating NAD+; however, you also need to be concerned about Vitamins C, D, Quercetin, Zinc, Methyltetrahydrofolate, and Selenium. All of these elements need to be considered both on their own merits, as well as, combined with the others. Vitamin D is particularly complex and should be part of a well thought out plan. If brain fog makes this too complicated, start with the nicotinic acid. Lack of nicotinic acid causes your body to hi-jack tryptophan and all hell breaks loose. Focus on supplementing with nicotinic acid.

Ade asked, “My American bread check didn’t show Niacin fortification?”

I replied, “Unfortunately, most Americans get their Niacin from fortified breakfast cereal.” They spray Niacin on the outside with several other vitamins. It would take 100 bowls of Wheaties/day to correct a niacin deficiency (not recommended).

Robert added, “17.5mg nicotinic acid per 100g of Kellogg’s cereal BUT this isn’t enough given the destructive diet of many of those eating the cereal. Continually hyperglycaemia like you would expect from the sugar in the cereal drives up CD38 and drives down NAD+ meaning you would need substantially more nicotinic acid. We are seriously beginning to suspect that many people actually have pseudo pellegra which is not easy to diagnose. However low Vitamin D levels and plasma tryptophan could be a good indicator of this as well as your risk from Covid-19.”

I replied, “The problem in the USA is… it is difficult to get prescribed Nicotinic Acid… and I have not been able to find it over-the-counter. Doctors and insurance companies don’t cover it. I have been trying to increase my dietary intake, as well as, taking a Inositol Nicotinate supplement.”

Robert offered, “Avoid Inositol Nicotinate (non-flushing B3 Niacin).”

Ade added, “We suggest you use nicotinic acid (niacin B3). We also believe it works most directly to increase NAD+. Niacin doesn’t cause liver problems. Non-flush niacin does though.”

After searching, I said, “It is surprisingly hard to find at a drug store. Neither CVS nor Walgreens carry it. I think I found it at Rite Aid. I’ll try to buy some today. If not, I’ll have to order it online.”

Robert explained, “The problem is that nicotininc acid costs around $15 per kg, so the nicotinic acid in bottle of 90 35mg tablets costs $0.047 . There is no money in it so big pharma isn’t interested in it.”

Finally, I found it, “If anybody is looking to get Niacin, I found it at Rite Aid… currently buy 1 get one free… confirmed with the pharmacist that it is the correct type.”

DOSAGE

WARNING: Niacin may cause flushing. Niacin flush is a common side effect of taking niacin supplements. It appears as red flushing skin, and may be accompanied by itching or burning. It usually lasts under 15 minutes. In almost all cases, flushing is not harmful. [If you have a severe flushing experience and are freaking-out, ingest apples or apple juice (pectin).] Start with 20mg consumed with a meal. Increase to 50mg with each meal. Keep increasing your daily dosage until you stop flushing. That is how you know the proper dosage for you. The more deficient you are the worse the flushing. If you do not flush the first time, you probably are not taking the right type of B3 Niacin. Some people prefer to smash it up and dissolve the dosage in a drink or mix it into their food.

Niacin may aggravate some medical conditions. You should consult your doctor prior to taking Niacin. Your doctor may prescribe higher does to help correct an NAD+ deficiency.

A complete NAD+ immune boosting diet.

Niacin / Vitamin B3
Niacin / Vitamin B3
Niacin Label
Niacin Label
B3, Niacin, COVID, and NAD+
B3, Niacin, COVID, and NAD+

COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity R.Millerc, A.R.Wentzel, G.A.Richards

What you need to know about COVID and
NAD+ deficiencies.

bookmark_borderCOVID, Vitamin D, Health, and Wellness

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By Daniel Brouse

Vitamin D Essentials
Vitamin D helps regulate the amount of calcium and phosphate in the body. These nutrients are needed to keep bones, teeth and muscles healthy.[1] Vitamin D is both a nutrient we eat and a hormone our bodies make. The active form of vitamin D tempers the damaging inflammatory response of some white blood cells, while it also boosts immune cells’ production of microbe-fighting proteins.[2] Studies have linked Vitamin D and the immune system to autoimmune diseases, some cancers, cardiovascular disease, infectious disease, schizophrenia, type 2 diabetes, and COVID.[3]

Vitamin D insufficiency affects almost 50% of the population worldwide.[4]

Sunlight is required for ultraviolet-B (UVB)-induced vitamin D production in the skin. During exposure to sunlight 7-dehydrocholesterol in the skin absorbs UV B radiation and is converted to previtamin D3 which in turn isomerizes into vitamin D3. Previtamin D3 and vitamin D3 also absorb UV B radiation and are converted into a variety of photoproducts some of which have unique biologic properties.[5} One of the photoproducts is transformed by UVB to corresponding, biologically active, secosteroids. New secosteroids are excellent candidates for therapy of fibrosing, inflammatory or hyperproliferative disorders including cancers and psoriasis (and COVID-19.)[5b]

How You Photosynthesize (And Why a Vitamin D Supplement Is Not the Same)

Immune Factories
Vitamin D is mostly produced in the skin in response to sunlight and is also absorbed from food eaten (about 10% of vitamin D is absorbed this way.)[6] The amount of Vitamin D you absorb through ingestion is probably not even adequate to regulate the amount of calcium and phosphate in the body. Even if it were adequate, it is not the synthesis of Vitamin D necessary for your immune factories. The creation of Vitamin D is only part of the synthesis creation. For instance, if you get COVID and it’s attacking your lungs, your skin, blood, circulatory system, lungs, respiratory system, and neurological system start a series of chemical reactions. These immune factories do a whole bunch of processes, assembly, creation, and attacks at the location needed. This is of particular importance when fighting COVID, and just as importantly, COVID’s long haulers syndrome. The creation of antibodies, memory T cells, naive T cells, and cytotoxic T cells at the location needed is dependent on the creation of Vitamin D. Synthesized Vitamin D is crucial for fighting the COVID infection. Long haulers syndrome involves another part of your immune factories. Synthesized Vitamin D is essential in correcting the depletion of NAD+. Your immune factories need Vitamin D, but more importantly, they need the other by-products produced when synthesizing Vitamin D (including production of microbe-fighting proteins, the hormone variety of D, previtamin D3, cholecalciferol, a variety of photoproducts with unique biologic properties including secosteroids, and photolyzed lymisterol and tachysterol.)

The Dangers of Vitamin D
Ingesting Vitamin D is not enough. Since Vitamin D is a fat-soluble vitamin, the body has no easy way of getting rid of excess Vitamin D and consuming Vitamin D may result in overdosing. Even worse, the body will not reap the full benefits from the Vitamin D that is not synthesized by the body. Which brings us to the larger DANGER of Vitamin D — sunlight

Exposure of the skin to sunlight is essential to create active Vitamin D (which includes the hormone variety of D, previtamin D3, cholecalciferol, a variety of photoproducts with unique biologic properties, and the ability to regulate calcium and phosphate metabolism.) The skin is responsible for producing vitamin D. During exposure to sunlight, ultraviolet radiation penetrates into the epidermis and photolyzes provitamin D3 to previtamin D3. Previtamin D3 can either isomerize to vitamin D3 or be photolyzed to lymisterol and tachysterol.[7]

Exposure to Ultraviolet (UV) Radiation can cause premature aging of the skin and signs of sun damage such as wrinkles, leathery skin, liver spots, actinic keratosis, and solar elastosis. UV rays can also cause eye problems. Most skin cancers are a result of exposure to the UV rays in sunlight. Both basal cell and squamous cell cancers (the most common types of skin cancer) tend to be found on sun-exposed parts of the body, and their occurrence is typically related to lifetime sun exposure.[8]

The Vitamin D Dilemma: How to Synthesis D Without Killing Yourself
As a general rule of thumb, you want to minimize the skin’s exposure to sunlight because UV radiation can kill you. On the other hand, not synthesizing Vitamin D by exposing your skin to sunlight can kill you. What to do? The answer is unique to every individual.

Obtaining the Optimal Amount of Sunshine
Sun induced vitamin D synthesis is greatly influenced by season, time of day, the weather, latitude, altitude, air pollution, skin pigmentation, sunscreen use, passing through glass and plastic, and aging.

You should never expose your eyes directly to the sun. People with blue eyes are at the greatest risk of permanent eye damage through exposure to UV radiation.

You should expose your skin based on the above factors. As an example, I am light skinned and live in Pennsylvania. On a clear summer day, I attempt five 3-minute exposures between 8-10 AM (for a total of 15 minutes.) I keep my head, face and ears protected. While keeping in motion doing an activity that takes me in and out of the shade, such as gardening, I try to remember to expose the inside of my wrists and forearms. Many afternoons (after 3PM) I will swim in a semi-shaded area. These controlled exposures are dependent on many factors most importantly air quality. There are countless uncontrolled exposures. A hat, sunglasses, sunscreen with a minimum SPF of 50, and a loss fitting long sleeve shirt are recommended. Your exposure plan should be well thought out in consultation with your doctor.

Vitamin D in the Big Picture
Nnicotinamide adenine dinucleotide (NAD+) depletion is of particular concern when it comes to COVID-19 and the resulting syndromes.[9] Synthesized Vitamin D and the bi-products of creating and metabolizing Vitamin D are part of a larger chemical equation. NAD+ depletion can be caused by COVID. NAD+ is essential for a functioning immune system. Lack of NAD+ in recovered COVID patients results in “long haulers syndrome“. Ade’s protocol to replenish NAD includes Vitamins C, B3, D, Quercetin, Zinc, and Selenium.[10] Each of these ingredients need to be considered both individually and combined. Taking mega-doses of any can be ineffective and deadly. A well thought out plan in consultation with medical professionals is prudent.

“Important not to forget that low NAD+ inhibits vitamin D activation. When you dig down deep enough it’s amazing how often you end up at NAD+,” added Robert Miller, co-author of COVID-19: NAD+ deficiency. “The three main steps in vitamin D metabolism, 25-hydroxylation, 1α-hydroxylation, and 24-hydroxylation are all performed by cytochrome P450 mixed-function oxidases (CYPs). These enzymes are located either in the endoplasmic reticulum (ER) (e.g., CYP2R1) or in the mitochondria (e.g., CYP27A1, CYP27B1, and CYP24A1). The electron donor for the ER enzymes is the reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent P450 reductase. Decreased intracellular NAD+ availability, leads to decreased NADPH availability.”[11]

We do not know Vitamin D’s role in the production of NAD+. We do know that the bi-products of photosynthesized Vitamin D are crucial to the immune system’s ability to fight infections. The photosynthesis of Vitamin D produces the Vitamin D you need, but more important is the timing of the unique photoproducts that are also created in the photosynthesis process — interferons. The interferons (IFNs) are the result of unique proteins made in the photosynthesis process that work with NAD+ to boost immune cells’ ability to fight microbes. The synergistic effects of IFNs and Vitamin D are part of the nonspecific immune system.

Vitamin D, Sunlight, the Season, and People of Color

Your Immune System and Photosynthesized Vitamin D

Interferons Interfere With Disease

What you need to know about COVID and NAD+ deficiencies.

1. Vitamins and minerals – Vitamin D NHS
2. Vitamin D Harvard / The Nutrition Source
3. Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19 British Cardiovascular Society
4. Vitamin D deficiency Holick MF / N Engl J Med. 2007;357:266–81
5. Sunlight and Vitamin D NIH
5b. Novel vitamin D photoproducts and their precursors in the skin NIH
6. Vitamin D Society For Endocrinology
7. Skin as the site of vitamin D synthesis NIH
8. Ultraviolet (UV) Radiation American Cancer Society
9. COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity Science Direct
10. COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity Ade Wentzel, R.Miller, G.A.Richards
11. Vitamin D Metabolism, Mechanism of Action, and Clinical Applications Science Direct

Vitamin-D / C38PDF

bookmark_borderCOVID-19 Long Haulers: SARS-CoV-2 Causes Dysfunctional Autoimmune Response

Posted on by admin

Coronavirus / COVID
By Daniel Brouse
Email: help@membrane.com
Last Updated December 18, 2021

Long haulers syndrome is in part due to “an autoimmune response that makes you feel symptoms in waves, or due to stress, and anxiety that triggers your immune system.”
— Daniel Brouse (August, 2020)

My original description of long-COVID was, “It feels like my body is having lots of micro cytokine storms.” Now two years later, the hypothesis has been proven true. “‘It is important to note that the severity of disease in humans is not determined only by virus replication but also by the host immune response to the infection, which may lead to dysregulation of the innate immune system, i.e. “cytokine storm”‘ (Omicron SARS-CoV-2 can infect faster and better)

My gravest concerns about long-COVID remain the same — what are the long term consequences of my immune system attacking my healthy body?

Do recovered coronavirus SARS-CoV-2 patients have immunity?
Why do some people appear to be reinfected?

Maybe. Those who recover from COVID-19 appear to have some immunity.(1) “It’s reasonable to assume that there will be protection for a time frame of one to three years,” says Florian Krammer.(2) Though recent examples suggest immunity, if any, may be very short lived. The Omicron variant appears to escape immunity from both prior infection and vaccination.

It appears there are 2 different types of COVID damage: direct damage from the COVID infection, as well as, a variety of post-COVID syndromes. The direct damage appears to be dependent on the severity of the COVID infection (which likely has to do with viral load, age, and underlying conditions.) The post-COVID long haulers syndrome appears to have little to do with the severity of the COVID infection and more to do with the post-infection immune response.

Then, why do some people appear to get reinfected?
“Over the last 2 weeks, I’ve been working with my doctor about recurring symptoms. It turns out I have ‘long haulers’ syndrome. Every couple of weeks I go through a wave of symptoms. Though not as severe as the original experience, it is still not pleasant. The symptoms don’t come on all at the same time, rather they cycle through over two weeks or so (and not necessarily in the same order.) I’m not infected again, nor am I contagious.(3) The symptoms include:
* difficulty breathing (feeling like you’re not taking in enough oxygen)
* congestion / mild cough
* stomach issues / diarrhea
* loss of taste, smell, and appetite
* night sweats
* nightmares / vivid dreams
* dizziness / the spins / foggy thinking
* headaches / body aches / soreness
* fatigue
* ear aches

What causes the recurring COVID symptoms?
It is too early for a definitive answer; however, an examination of cases appear to point to an autoimmune response due to epigenetic changes caused by the virus.

Is the person still contagious? No.

How long will it take for the immune system to recognize that there is no longer a threat? It’s too early to tell. So far, symptoms have been observed for over 2 years. BUT, there are still many questions about COVID-19 and autoimmune and autoinflammatory diseases.

“Emerging reports show that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection precedes the appearance of various autoimmune and autoinflammatory diseases, including paediatric inflammatory multisystemic syndrome (PIMS) or multisystem inflammatory syndrome in children (MIS-C), thus adding to the growing mystery of this virus and raising questions about the nature of its link with autoimmune and autoinflammatory sequelae.” (4)

What is long haulers syndrome?
The vast majority of long haulers experience fluctuations both in the type and intensity of symptoms over the course of being symptomatic.(5)

Research is pointing to “an autoimmune response due to changes in the genes of the infected host” for causing “long haulers syndrome” in adults. “Support groups on Facebook include thousands of people who say they have been wrestling with serious COVID-19 symptoms for at least a month, if not two or three. The groups have coined a name for themselves: ‘long-haulers.’ But their lives have been irrevocably changed by the onslaught of symptoms — relentless and rolling waves of fever, headache, nausea, and the terrifying inability to catch their breath. For Roberts, it’s robbed her of time. ‘I was so good. This COVID-19 has stolen my life,’ she says.” (6)

According to a WHO report, most people fall into one of two groups when it comes to the virus. Approximately 80% of those with COVID-19 end up having a mild response and most of those cases resolve in about two weeks. For people who have a severe response to the virus, it can take between three and six weeks to recover.

But now, there is growing concern over a separate group that doesn’t seem to fall into either of those categories. A number of people are now reporting lingering symptoms of the illness for one, two or even three months. This new group is mixed with those who experienced both mild and severe cases. As health experts step in to try to manage these patients and learn more, many are referring to this group as coronavirus “long-haulers” or “long-termers.”

“We’re now seeing a percentage of patients whose symptoms seem to be lasting a while,” explains family medicine provider Christopher Babiuch, MD. “This is challenging because everyone’s needs are so unique. We’re finding that collaborating as a team between different specialists helps to manage and support these patients, but there’s a lot that we just don’t know yet.” (7)

What is actually causing the immune system to have an autoimmune disconnect?
All the research is still theoretical. More studies and longer recovery times are required to confirm the theories. So, we still do not know for sure about the antigen presentation of COVID-19.

Possibly for the longhaulers it’s cytokine imbalance which causes an Down Regulating NAD+, * Up Regulating IDO, Rogue Antibodies, and other conditions that result from genetic changes. The symptomatology improves vastly with NAD+ precursors but if cellular damage or organ damage is to occur the damage is likely permanent.

“The SARS-CoV-2 hyperinflammatory response is associated with high mortality. This hypothesis suggests that a deficiency of nicotinamide adenine dinucleotide (NAD+) may be the primary factor related to the SARS-Cov-2 disease spectrum and the risk for mortality, as subclinical nutritional deficiencies may be unmasked by any significant increase in oxidative stress.

NAD+ levels decline with age and are also reduced in conditions associated with oxidative stress as occurs with hypertension, diabetes and obesity. These groups have also been observed to have high mortality following infection with COVID-19. Further consumption of NAD+ in a pre-existent depleted state is more likely to cause progression to the hyperinflammatory stage of the disease through its limiting effects on the production of SIRT1,” said Ade Wentzel, co-author of the research.(9)

Does an auto-immune disconnect explain all long haulers’ symptoms?
No. Evidence is mounting that long haulers are unique and may have a variety of ailments. Many post-viral COVID cases exhibit the Lyme-like autoimmune disfuntions. Many also exhibit symptoms, such as, dysautonomia (10)(11). Long haulers have reported over 100 different symptoms. COVID appears to impact many of the body’s systems including respiratory, circulatory, cardiovascular, neurological, and immune systems to name a few. This makes diagnosis and treatment very confusing for doctors. And, those aren’t the only difficulties. An additional problem for diagnosing is memory T-cells. Some people’s memory T-cells may be getting erased. That means your body does not recognize previous infections nor vaccines. So, long haulers syndrome may be a combination of new conditions (Lyme-like autoimmune, dysautonomia, chronic fatigue, etc.) AND re-infections to everything you use to be immune to… with no one person having the same ailments as another.

Is there a treatment or cure for long haulers syndrome?
No. Currently, there is no cure or treatment for the onset of these autoimmune responses. The closest comparison appears to be when Lyme disease was first discovered or HIV.

Ade Wentzel replied: You can take nicotinic acid orally or niagen (if you have deep pockets). The IV will help, but however you supplement, you need to keep going for at least a good few months.

Ade has developed a protocol for a NAD+ deficiency: NAD+: Vitamin B3, Vitamin D and sunlight, Vitamin C, Quercetin, Zinc, and Selenium

COVID-19 Index

FOOTNOTES:
0. Technically speaking a virus is never alive. It is only RNA. Dead is not the scientifically correct way to describe it. But, in all essence, the virus is dead.

REFERENCES:
1. Potent antibodies found in people recovered from COVID-19 (NIH)
2. How Long Will Immunity To The Coronavirus Last? (NPR)
3. COVID-19 Testimonial (The Membrane Domain)
4. Autoimmune and inflammatory diseases following COVID-19 (Nature)
5. COVID-19 Prolonged Symptoms Survey – Analysis Report (MIT)
6.What It’s Like When COVID-19 Lasts For Months (NPR)
7. What It Means to Be a Coronavirus “Long-Hauler” (Cleveland Clinic)
8. Study: COVID-19 antibodies decay quickly after mild illness (University of Minnesota Center for Infectious Disease Research and Policy)
9. COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity (Science Direct)
10. Dysautonomia: An Overlooked Neurological Manifestation in a Critically ill COVID-19 Patient (NIH)
11. Redefining Covid-19: Months after infection, patients report breathing difficulty, excessive fatigue (CNN)

ADDITIONAL REFERENCES:
A. Long-term consequences of COVID-19: research needs (The Lancet)
B. Humoral Immune Response to SARS-CoV-2 in Iceland (New England Journal of Medicine)
C. Is a Bradykinin Storm Brewing in COVID-19? (The Scientist)
D. The Power of Antibody-Based Surveillance (New England Journal of Medicine)
E. Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity bioRxiv
G. Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19: rationale for clinical management British Cardiovascular Society