Covid-19 mRNA Vaccine Sparks Immune Response to Fight Cancer
The same mRNA technology that helped the world battle COVID-19 is now showing extraordinary promise in the fight against cancer. A new study published in Nature has revealed that COVID-19 vaccines can activate a powerful immune response that appears to “wake up” the body’s natural defenses against tumors — nearly doubling the median survival length of cancer patients in some cases.
The collaborative research — led by the University of Florida and the University of Texas MD Anderson Cancer Center — analyzed the medical records of more than 1,000 cancer patients. The results suggest that the immune activation triggered by the COVID-19 mRNA vaccine may enhance the body’s anti-tumor immunity.
This marks what scientists are calling a defining moment in more than a decade of research into mRNA-based therapeutics designed to mobilize the immune system. If validated through a randomized clinical trial now being planned, the discovery could transform modern oncology.
“The implications are extraordinary — this could revolutionize the entire field of oncologic care,” said Elias Sayour, M.D., Ph.D., a UF Health pediatric oncologist and the Stop Children’s Cancer/Bonnie R. Freeman Professor for Pediatric Oncology Research. “We could design an even better, nonspecific vaccine to mobilize and reset the immune response — a universal, off-the-shelf cancer vaccine for all cancer patients.”
This breakthrough builds on Sayour’s prior eight years of work developing mRNA-lipid nanoparticle systems that deliver immune-stimulating messages to the body’s cells. The principle is simple but profound: use mRNA to retrain the immune system to recognize and destroy cancer cells, much like it does with viral infections.
The new findings reinforce the growing belief that mRNA vaccines — initially deployed to fight COVID-19 — have far-reaching applications beyond infectious disease. The technology allows scientists to rapidly program the immune system with precise instructions, unlocking a new era of personalized and universal medicine.
Jeff Coller, Ph.D., a leading mRNA scientist at Johns Hopkins University, said the study illustrates how Operation Warp Speed continues to save lives long after the pandemic’s peak.
“The results from this study demonstrate how powerful mRNA medicines truly are and that they are revolutionizing our treatment of cancer,” said Coller.
The study’s authors emphasize that while the results are preliminary, they represent a crucial step toward what many once considered science fiction — a universal cancer vaccine.
mRNA, or messenger RNA, naturally exists in every living cell, carrying the instructions needed to make proteins. The COVID-19 vaccines used synthetic mRNA to teach the immune system how to recognize and neutralize the SARS-CoV-2 virus. This same mechanism, researchers now believe, can be redirected to target cancer cells by enhancing immune surveillance and resetting dysfunctional immune pathways.
If these early results are confirmed in upcoming clinical trials, the ripple effects will be enormous — redefining not only cancer treatment but the future of immunology itself.
Part I: What is a persistent virus? (The Chronic Infection Hypothesis)
Persistent viruses are not cleared but remain in specific cells of infected individuals. Persistent infections may involve stages of both silent and productive infection without rapidly killing the host. Diseases caused by persistent virus infections include acquired immune deficiency syndrome (AIDS), AIDS-related complexes, chronic hepatitis, Epstein-Barr (the virus that causes most cases of cases of mononucleosis), subacute sclerosing panencephalitis (chronic measles encephalitis), chronic papovavirus encephalitis (progressive multifocal leukoencephalopathy), several herpesvirus-induced diseases, and COVID-19.
“Some of the theories for what may be causing long-COVID symptoms include the persistence of the virus. So, instead of the virus coming and going, it sticks around causing inflammation, auto-immune problems and changes in the microbiome,” Dr. Michael Peluso, an infectious disease specialist at the University of California, San Francisco said.
“You can start thinking about getting COVID as almost an accelerant to aging. The viral infection accelerates the aging process in people,” said Dr. Ziyad Al-Aly, director of the Clinical Epidemiology Center at Washington University in St. Louis and the chief of research and education service at Veterans Affairs St. Louis Health Care System.
Dr. Al-Aly researched data from millions of people across the country. The studies on kidney outcomes in long COVID, long COVID in the brain and long COVID in the heart had similar patterns.
“We have seen that people are losing about three to four percent kidney function in the year following that infection. That usually happens with three to four years of aging,” Al-Aly said.
Long-term SARS-CoV-2 Found in Multiple Organs
COVID has been found to persist for months in individuals even if their case was mild. The virus continues to infect multiple organs including the brain. The U.S. National Institutes of Health said they found the pathogen is capable of replicating in human cells beyond the respiratory tract and can infect all organs.
In 2024, researchers from Helmholtz Munich and Ludwig-Maximilians-Universität (LMU) found the SARS-CoV-2 spike protein can persist in the brain’s protective layers (the meninges) and the skull’s bone marrow indefinitely, potentially triggering chronic inflammation and increasing the risk of neurodegenerative diseases. The team, led by Prof. Ali Ertürk, Director at the Institute for Intelligent Biotechnologies at Helmholtz Munich, also found that mRNA COVID-19 vaccines significantly reduce the accumulation of the spike protein in the brain.
A Connecticut patient had/has COVID for 471 Days (and still going as of July 02, 2022) that has evolved into 3 new lineages. She currently has three types of persistent COVID at the same time. Two of the mutations were created by the patient and will likely develop into more mutations. “The chronic infection hypothesis for novel SARS-CoV-2 variant emergence is increasingly gaining credence following the appearance of Omicron. Here we investigate intrahost evolution and genetic diversity of lineage B.1.517 during a SARS-CoV-2 chronic infection lasting for 471 days (and still ongoing) with consistently recovered infectious virus and high viral loads. During the infection, we found an accelerated virus evolutionary rate translating to 35 nucleotide substitutions per year, approximately two-fold higher than the global SARS-CoV-2 evolutionary rate. This intrahost evolution led to the emergence and persistence of at least three genetically distinct genotypes suggesting the establishment of spatially structured viral populations continually reseeding different genotypes into the nasopharynx.” (Accelerated SARS-CoV-2 intrahost evolution leading to distinct genotypes during chronic infection)
The chronic infection hypothesis is important work. Ziyad Al-Aly, director of the clinical epidemiology center at the Veterans Affairs St. Louis Health Care System in Missouri, who has led separate studies into the long-term effects of COVID-19 says, “For a long time now, we have been scratching our heads and asking why long-COVID seems to affect so many organ systems. This paper sheds some light, and may help explain why long-COVID can occur even in people who had mild or asymptomatic acute disease.”
The virus lives for an undetermined amount of time after you test negative. These autopsies were performed on people up to 230 days after asymptomatic and mild cases of COVID.
“We show that SARS-CoV-2 is widely distributed, even among patients who died with asymptomatic to mild COVID-19, and that virus replication is present in multiple pulmonary and extrapulmonary tissues early in infection. Further, we detected persistent SARS-CoV-2 RNA in multiple anatomic sites, including regions throughout the brain, for up to 230 days following symptom onset. Despite extensive distribution of SARS-CoV-2 in the body, we observed a paucity of inflammation or direct viral cytopathology outside of the lungs. Our data prove that SARS-CoV-2 causes systemic infection and can persist in the body for months.”
“One patient in the autopsy study was a juvenile who likely died from unrelated seizure complications, suggesting infected children without severe COVID-19 can also experience systemic infection.”
In yet another study, Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infection, scientists found COVID in people’s stool up to 7 months after they tested negative for COVID. “The extended presence of viral RNA in feces, but not in respiratory samples, along with the association of fecal viral RNA shedding with GI symptoms suggest that SARS-CoV-2 infects the GI tract and that this infection can be prolonged in a subset of individuals with COVID-19.”
PART II: What does it mean? (SARS-CoV-2 and Your Kids)
Is SARS-CoV-2 being a persistent virus and the risks associated with persistent viruses. Here are a couple examples:
Chicken pox and Shingles. “Shingles is caused by varicella zoster virus (VZV), the same virus that causes chickenpox. After a person recovers from chickenpox, the virus stays dormant (inactive) in their body. The virus can reactivate later, causing shingles.”
Mononucleosis, Multiple Sclerosis, and Epstein-Barr. The Epstein-Barr virus is a persistent virus linked to causing Mononucleosis (Mono) and Multiple Sclerosis (MS). Studies have also found “people who developed shingles had four times the risk of being diagnosed with MS within the following year.”
Persistent viruses often cause long term health problems, a decreased quality of living, and a shortened lifespan. Some of these chronic conditions will become apparent immediately. Some of the chronic conditions, cancers, and other ailments may not present themselves for years. Research has shown, “Associations between gut microbiota composition, levels of cytokines and inflammatory markers in patients with COVID-19 suggest that the gut microbiome is involved in the magnitude of COVID-19 severity possibly via modulating host immune responses. Furthermore, the gut microbiota dysbiosis after disease resolution could contribute to persistent (long-COVID) symptoms.” Good gut bacteria is a critical component of the human immune system.
Where is COVID Lurking in the body?
The problem with studying persistent viruses is you typically need to do an autopsy to obtain the tissue. A new technique can be used on live volunteers by performing a PET (Positron Emission Tomography) scan. The scan can find persistent virus locations in the body of the HIV virus. They are also applying this technique to find where the persistent SARS-CoV-2 is lurking in long-COVID patients.
This BBC episode of Science In Action “A medical scan which reveals where HIV and other viruses hide in the body” explains:
Protect Children
Unfortunately, I have seen many of my friends posting about their children having COVID. These kids now have a forever health risk. It may be many years before we know all the consequences; however, we already are seeing that COVID elevates the severity of conditions one is predisposed to, such as, a pre-diabetic that gets COVID turning into a diabetic. This is one of the reasons so many children are being diagnosed for COVID when hospitalized for other conditions. COIVD is triggering other ailments. “Persons aged <18 years with COVID-19 were more likely to receive a new diabetes diagnosis >30 days after infection than were those without COVID-19 and those with prepandemic acute respiratory infections,” said the CDC’s Morbidity and Mortality Report.
One should do everything possible to avoid exposure to their children. There is zero (0) evidence of prolonged immunity through infection. So, there is no (none, zip, nadda) benefits of infection. There is a 99% chance of a negative outcome from infection.
Persistent viruses are not cleared but remain in specific cells of infected individuals. Persistent infections may involve stages of both silent and productive infection without rapidly killing the host. Diseases caused by persistent virus infections include acquired immune deficiency syndrome (AIDS), AIDS-related complexes, chronic hepatitis, subacute sclerosing panencephalitis (chronic measles encephalitis), chronic papovavirus encephalitis (progressive multifocal leukoencephalopathy), spongioform encephalopathies (caused by prions), several herpesvirus-induced diseases, and COVID-19. The mechanisms by which persistent infections are maintained involve both modulation of virus and cellular gene expression and modification of the host immune response.
COVID has been found to persist for months in individuals even if their case was mild. The virus continues to infect multiple organs including the brain. The U.S. National Institutes of Health said they found the pathogen is capable of replicating in human cells beyond the respiratory tract and can infect all organs.
There are many questions about Long-COVID (also known as Long Haulers Syndrome.)
Long-COVID is the condition most people develop after recovering from the SARS-CoV-2 virus. Between 40 and 70% of recovered COVID cases report lingering symptoms, but it is quite likely 99.9% of recovered individuals have silent conditions. COVID-19 makes a multitude of changes to the human genome. Some of the changes result in noticeable symptoms, such as, brain fog, fatigue, soreness, night sweats, diarrhea, and loss of taste. There are also many changes to the genome that may go unnoticed, such as, an increase risk of cancer, rogue antibodies, and blood clotting.
The epigenetic changes that cause Long-COVID are very similar to having HIV.
The Journal Nature reports in the article HIV infection alters the human epigenetic landscape, “Early in 2010, a study on the DNA methylation status of B lymphoma confirmed that HIV infections may induce novel epigenetic changes, including DNA methylation status alteration of specific functional sites.”
“Immune dysregulation during HIV infection can increase anemia risk through red blood cell destruction (hemolysis) or ineffective red blood cell production,” according to BMC Infectious Diseases. This is similar to symptoms in some Long-COVID patients. Long-COVID is known to result in a variety of blood issues.
“HIV enters its genetic information into helper T cells to make copies of itself. When this happens, the helper T cells die. This severely disrupts the immune response. Low levels of helper T cells mean killer T cells and other white blood cells do not receive as much information about pathogens in the body,” as reported in Medical News Today. Long-COVID is also suspected of interfering with T cells and the immune system. Long-COVID causes an upregulation in IDO. Indoleamine 2,3-dioxygenase (IDO) is an immune checkpoint molecule in the sense that it is an immunomodulatory enzyme produced by alternatively activated macrophages and other immunoregulatory cells. IDO is known to suppress T and NK cells, generate Tregs and myeloid-derived suppressor cells, and also supports angiogenesis.
In December 2021, typical seasonal viruses’ severity was up suggesting recovery from COVID results in a compromised immune system. T cells may lose effectiveness against any pathogen. It is estimated half of the U.S. population has had a COVID infection. Hospitals are seeing a sharp rise in Flu, RSV, and other viral infections. It is also likely infants and younger children are contracting the viruses due to their parents compromised immune systems.
The epigenetic changes caused by both Long-COVID and HIV compromise the immune system.
“This is remarkably important work,” said Ziyad Al-Aly, director of the clinical epidemiology center at the Veterans Affairs St. Louis Health Care System in Missouri, who has led separate studies into the long-term effects of COVID-19. “For a long time now, we have been scratching our heads and asking why long COVID seems to affect so many organ systems. This paper sheds some light, and may help explain why long COVID can occur even in people who had mild or asymptomatic acute disease.”
COVID and Cats:
A scientist friend called me last night… wanted to make sure I stocked up on enough masks and supplies for the next round featuring Omicron. We got to talking about severity of variants and what the most likely scenarios are:
1) the virus stays for a prolonged period in an unvaccinated immune compromised individual
2) the virus jumps back into animals and mutates before jumping back into humans
His theory is cats are a reservoir for SARS-CoV-2. And, that cats are spreading COVID to mice and deer… and back into humans. Some studies have shown 20-50% of cats that belong to owners that have had COVID develop COVID. Studies have also found that cats can transmit the virus to other cats. The risk is especially great for pets that share a bed with their owner.
Some other things we discussed:
* the pandemic is going to go on for years
* there is no natural immunity to Omicron
* there may be no immunity from vaccines to Omicron
* the severity of Omicron will take some time to determine… since we don’t know how much immunity / less severe symptoms vaccines may offer, yet. There is some possibility that prior infection may offer some protection to severity, but that is unlikely.
* N95 masks and social distancing offer the best protection to all variants of COVID
* we do not fully understand the long term effects of COVID. Until we do, avoid contracting the virus… and probably after we do understand, it will become clear the reduction in life expectancy and quality of life
We’re starting to find out more about Omicron:
1)”Previous infection used to protect against Delta but now with Omicron that doesn’t seem to be the case,” said Anne von Gottberg, microbiologist at South Africa’s National Institute for Communicable Diseases.”
2) risk of breakthrough vaccination is also much higher. Out of 600 fully vaccinated travelers from South Africa, 61 tested positive for COVID. 16 of those were Omicron.
3) a much higher percentage of 20-30 years are being hospitalized
4) an alarming percentage of children under 2 are being hospitalized.
5) the Omicron variant has become dominant in South Africa. Cases of COVID have gone from 200/day, to 400, to 1,000 to 2,000, to 4,000, to 8,000, to over 11,000/day in as many days.
Remember, when you hear of cases being “mild”, that means mild for COVID (eg not hospitalized). All of the cases I’ve studied have been symptomatic individuals that are fully vaccinated.
Omicron Update December 9, 2021
Omicron Update:
* Pfizer says the booster offers protection
* Pfizer says 4th dose may be required
* South Africa says Pfizer offers 1/40th the protection as Delta
* Reinfection is 3 times more likely than with Delta
* South Africa cases are up 255% in a week
* 4x’s more transmissible than Delta
* UK cases could exceed 1 million by the end of this month
* typical seasonal viruses’ severity is up… suggesting recovery from COVID results in a compromised immune system. T cells may lose effectiveness against any pathogen
“In other words, Omicron is spreading in highly immune populations as quickly as the original virus did in populations with no immunity at all. If this holds and is left uncontrolled, a big Omicron wave lies ahead—bigger than we would have expected with Delta. Cases were already surging ahead of winter. The U.S. already had a too-low vaccination rate. And now Omicron threatens to eat away at the immunity we thought we had.”
About 4 weeks after my second dose of Moderna, I noticed my NAD+ symptoms resolved (diarrhea, headaches, fatigue, soreness, temperature regulation, night sweats, etc.) Even after stopping the Niacin treatment, all of the NAD+ downregulation appears to be “back to normal”.
Finally being NAD+ symptom free, I was able to discover my IDO upregulation symptoms (tinnitus, feels like a cold in the ears, sinus pressure, vertigo, brain fog, etc.) Within 90 days of my second jab, all these symptoms improved dramatically. Now, the only time I feel any effects is going from low pressure to high pressure. The symptoms are very mild compared to last summer.
My conclusion is one of two things.:
1) after 23 moths, my damaged cells died. This is unlikely since the average life of a cell is nine years.
2) or more likely, the vaccine caused my immune system to clear the long-COVID damage.
Get vaccinated. Less likely to get COVID in the first place. Might fix your long-COVID if you have it.
To date, there is zero (0) evidence that contracting the original strain of COVID gives you any immunity to re-infection — natural immunity. On the other hand, there are a multitude of examples of re-infection.
Natural immunity to the original strain lasts on average from 60 days to 6 months; however, there does not appear to be any natural immunity to the variants.
In India’s recent wave, 1 in 4 Delta cases were re-infections. “Antibodies against Sars-CoV-2 — the virus that causes Covid-19 — were found in about 27% of the 91 participants at a time when the second wave was raging in the country, researchers at the Institute of Genomics and Integrative Biology, National Centre for Disease Control and the Cambridge University, said.” — Hindustan Times
“During the Novavax vaccine trials in South Africa, the study found an overall primary efficacy of 49.4% in 4,400 participants, meaning about half of the patients vaccinated and later infected did not experience symptoms. Genomic analyses revealed that about a third of the 4,400 were previously positive for infection, meaning the South African variant was then and is now capable of reinfection, evading neutralizing antibodies in a similar capacity to the Brazilian variant.”
“The study also showed that prior infection with an earlier version of the virus did not reduce the risk of COVID-19 caused by the South African variant among people who got placebo shots.” — Reuters
“Among Kentucky residents infected with SARS-CoV-2 in 2020, vaccination status of those reinfected during May–June 2021 was compared with that of residents who were not reinfected. In this case-control study, being unvaccinated was associated with 2.34 times the odds of reinfection compared with being fully vaccinated.” — CDC
“Our case series shows that reinfection with different strains is possible, and some cases may experience more severe infections with the second episode. The findings also suggest that COVID-19 may continue to circulate even after achieving herd immunity through natural infection or vaccination, suggesting the need for longer-term transmission mitigation efforts.” — Journal of Investigative Medicine
Vaccines do not appear to be much more effective against the Delta variant than natural immunity through infection. The increase of breakthrough cases has been increasing in lock-step with the increase spread of the Delta variant. “Fewer than 10% of new coronavirus infections occurred in fully vaccinated people in the weeks before June, but the rate increased this summer. In the first four weeks of August, roughly 30% of infections were in fully vaccinated individuals.” — The Star Tribune
A study by the CDC found vaccine efficacy dropped from roughly 90% to 66% as the Delta variant emerged. “This report updates vaccine effectiveness (VE) estimates including all COVID-19 vaccines available through August 14, 2021, and examines whether VE differs for adults with increasing time since completion of all recommended vaccine doses.” — CDC
Another CDC study that compared natural immunity to vaccination has found — “Among COVID-19–like illness hospitalizations among adults aged ≥18 years whose previous infection or vaccination occurred 90–179 days earlier, the adjusted odds of laboratory-confirmed COVID-19 among unvaccinated adults with previous SARS-CoV-2 infection were 5.49-fold higher than the odds among fully vaccinated recipients of an mRNA COVID-19 vaccine who had no previous documented infection.”
CONCLUSION PART I
There is a need for longer-term transmission mitigation efforts. Because reinfection is likely, vaccines efficacy is not high enough, and new variants are emerging, herd immunity is not achievable. Humans can not learn to live with the virus. Mitigation efforts must be made to stop community spread.
CONCLUSION PART II
COVID causes an immune dysfunction. When a person become infected, the SARS-CoV-2 virus alters your genes in order to infect you. “We identified EP300, MOV10, RELA, and TRIM25 as top candidates, and more than 60 additional proteins involved in the epigenetic response during viral infection that has therapeutic potential.” — Nature
When a person recovers from the virus, they are left with multiple gene alterations to there immune system. It is impossible for natural immunity to be feasible in an individual with an immune system that is compromised by a COVID-19 infection.
COVID survivors are left with a severe NAD+ deficiency, and an upregulation of IDO (which suppresses your T and NK cells.) Short term this makes your immune system dysfunctional. This means your antibodies can’t function properly and have little to no memory. Long term it makes you more likely to have heart, blood, respiratory, and neurological disorders. You are at high risk of developing dementia. In addition, you have reduced P53 genes (tumor suppression genes) putting you at higher risk of cancer. — The Membrane Domain
I strongly advise against contracting COVID.
OMICRON UPDATE
December 4, 2021
A study out of South Africa, “Increased risk of SARS-CoV-2 reinfection associated with emergence of the Omicron variant in South Africa,” found that individuals who recently recovered from the Delta variant were afforded little to no protection from the Omicron variant. “Population-level evidence suggests that the Omicron variant is associated with substantial ability to evade immunity from prior infection. This finding has important implications for public health planning, particularly in countries like South Africa with high rates of immunity from prior infection.”
As stated above, everybody is advised to:
* speak to your doctor
* get vaccinated
* wear an N95 mask
* stay socially distanced
UPDATE June 2022: No Immune Boost From Omicron
“If you were infected during the first wave, then you can’t boost your immune response if you have an Omicron infection,” said Prof Rosemary Boyton, of Imperial College London, a co-author of the study. “When Omicron started flying around the country, people kept saying that’s OK, that will improve people’s immunity,” said Boyton. “What we’re saying is it’s not a good booster of immunity.”
“It’s actually worse than that, because the adaptations that the spike [protein] has now are actually inducing a kind of regulation or shutdown of immune response,” Prof Danny Altmann, another author of the study, adding that while the study looked at responses to the BA.1, similar findings were likely for other subvariants of Omicron.
by Daniel Brouse
August 23, 2021
help@membrane.com
Q: Why are there so many breakthrough cases of COVID in the vaccinated?
A: There are several reasons why there are breakthrough cases with any vaccine; however, COVID is different. Many of the vaccinated people getting COVID already had COVID prior to being vaccinated. This is the second time they have contracted the virus.
Once you have had COVID, your immune system is compromised. You should consider yourself immune compromised. The vaccine will not fully compensate for that fact. COVID damages your immune system. The virus makes your antibodies dysfunctional. The virus suppresses your memory T cells. The virus does a lot more to thwart an immune response. So though you may have the antibodies, maybe even lots and lots of antibodies, you’ve got Nobody’s At Home Syndrome. There is little to no immune response regulation nor coordination. This is also why natural immunity through infection is impossible. COVID erases the memory from your memory cells, so to speak. It can’t even remember itself.
Q: Is this a hallmark of the virus? I mean is this finding in all post COVID cases?
A: Yes. Severity of illness does not appear to be a factor (mild cases to severe all exhibit similar compromises to the immune system.) The exception is asymptomatic cases. We still don’t know about asymptomatic cases. The evidence is pointing to all cases that progress past the nasal passage result in immunocompromised individuals. There also is a small percentage (1 in 100,000) of people that appear to evade impact.
The scientific community is looking for ways to cure the problems. So far, there is only some success in treating the symptoms. There is nothing else to really compare to long-COVID. A similar condition happens to some measles survivors that bares a slight resemblance in T cell response, but it is not same. “Measles induces immune suppression through a process called immune amnesia. Studies in non-human primates revealed that MV actually replaces the old memory cells of its host with new, MV-specific lymphocytes. As a result, the patient emerges with both a strong MV-specific immunity and an increased vulnerability to all other pathogens.” COVID appears to use a different process that involves T cell suppression. There is also some similarity to HIV. “HIV attacks a specific type of immune system cell in the body. It’s known as the CD4 helper cell or T cell. When HIV destroys this cell, it becomes harder for the body to fight off other infections.” Again, COVID appears to use a different mechanism to suppress T cells.
Q: What do we know about the immune system post-COVID?
A: We know at least two important pieces of the puzzle:
1) The SARS-CoV-2 causes gene expressions in the host that result in dysfunctional NAD+. The virus makes it harder for the body to create NAD+ and also increases the breakdown in NAD+. “NAD regulates the inflammatory response in immune and non-immune cells through Sirtuins. Epigenetic regulation of histones and non-histone proteins is induced by sirtuins and is essential for the development, reprogramming, and differentiation of the immune system and its related pathologies. A deregulation of the NAD+ levels has been associated with metabolic diseases and aging-related diseases, including neurodegeneration, defective immune responses, and cancer.” — NAD-immune-system
2) The SARS-CoV-2 causes gene expressions in the host that result in upregulation of IDO (Indoleamine-2,3-dioxygenase). “IDO is an immune checkpoint molecule in the sense that it is an immunomodulatory enzyme produced by alternatively activated macrophages and other immunoregulatory cells. IDO is known to suppress T and NK cells, generate Tregs and myeloid-derived suppressor cells, and also supports angiogenesis.’ (Wikipedia)
Q: How long do these gene expressions (epigenetics) last? How long does long haulers syndrome last?
A: We don’t know how long post-COVID cases will suffer with a compromised immune system. Long-COVID patients from January of 2020 are still immune compromised. It is possible the genetic changes will never revert.
What do we know about the Delta variant and vaccines?
OVERVIEW
The efficacy of mRna vaccines is about 79% against contracting the Delta variant. Non-mRna vaccines are between 40-60% effective against Delta. Vaccines lose efficacy at about 3%/month after six months of being fully vaccinated. Vaccines appear to help contain the Delta variant to the nasal passage. You are less likely to develop the epigenetic changes to your genes (long-COVID). Previous infection of COVID offers no protection to the Delta variant. Get vaccinated.
THE BAD NEWS
The delta variant is much more contagious than any other COVID strain. Vaccines also appear to be less effective at preventing infection from the Delta variant. On July 30, 2021, the Delta variant was much more predominant in Louisiana than in Pennsylvania. In Louisiana, 15% of the deaths were in vaccinated individuals. In Pennsylvania, 1% of the deaths were in vaccinated individuals.
Recent studies also revealed that vaccinated people can transmit the virus both asymptomatically and symptomatically.
THE GOOD NEWS
The vaccines are still tremendously effective at preventing infection, hospitalization and death from Delta.
Vaccinated individuals that get infected with Delta overwhelmingly stop the virus in their nasal passage. The virus never infects the lungs nor spreads to other systems causing blood clots or other life threatening conditions.
Since Delta never reaches the lungs and other organs, vaccinated people that test positive for COVID are unlikely to develop long-COVID (Long Haulers Syndrome). Long-COVID is caused by the coronavirus making epigenetic and genetic changes to your genes. COVID partially disables the immune system. Some of the dismantling is temporary lasting only a few days. Some of the dismantling is chronic and may last a lifetime.
The most common long term side-effect from COVID-19 are:
* the disruption of the body’s ability to produce and retain NAD+. Without NAD+ your immune system can not metabolize most vitamins, can not regulate body temperature, nor properly activate an immune response. Lack of NAD+ will cause your body to hi-jack tryptophan and cause all sorts-of mental and neurological disorders. Lack of NAD+ has been associated with over one hundred post-COVID ailments.
* upregulation of Indoleamine 2,3-dioxygenase (IDO). “IDO is an immune checkpoint molecule in the sense that it is an immunomodulatory enzyme produced by alternatively activated macrophages and other immunoregulatory cells. IDO is known to suppress T and NK cells, generate Tregs and myeloid-derived suppressor cells, and also supports angiogenesis.’
In the vast majority of cases, vaccinated individuals do not suffer from alterations to the genes. Vaccination almost always prevents Delta from developing into long-COVID’s Long Haulers Syndrome.
PROTECT YOUR GENES FROM THE VIRUS
GET VACCINATED
WEAR A MEDICAL GRADE MASK (to prevent the virus from getting in your nasal passage in the first place) TAKE A NIACIN SUPPLEMENT
AVOID ANTI-VAXXERS LIKE THE PLAGUE
