Tag: diet

bookmark_borderThe Gut Clock: How Microbial Rhythms Shape Health, Sleep, and Metabolism

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by Daniel Brouse
September 9, 2025

The gut microbiome goes through several important shifts over the course of a day, and these changes are tightly linked to the body’s circadian rhythm. These microbial populations do not operate randomly; they follow a daily cycle, synchronizing with light–dark patterns and feeding–fasting intervals. When fasting periods extend too long, or when meals are poorly timed, this rhythm can be disrupted—throwing off the delicate balance of microbial activity.

Daily microbial cycles play a central role in regulating the sleep–wake cycle. Certain microbial groups become more active in the morning to help stimulate metabolism and promote alertness, while others dominate at night, supporting rest, repair, and the production of neurotransmitters that influence sleep quality. Disrupting this cycle can impair both sleep and metabolic health, creating a feedback loop where poor sleep further destabilizes the gut microbiome, and vice versa.

A growing body of evidence shows that not just the substance of meals but also their timing is one of the most significant factors in long-term health outcomes. Eating late at night or consuming heavily processed foods with added sugars can spike blood glucose, disrupt blood pressure regulation, and increase the risk of insulin resistance, diabetes, and hypertension. Conversely, aligning meal timing with the body’s circadian rhythm improves glucose tolerance, cardiovascular stability, and even cognitive performance.

The best practice, according to nutrition science, is to eat larger meals earlier in the day—when the body’s metabolism is most efficient—and to keep dinner light, simple, and consumed at least three hours before sleep (and preferably longer). Avoiding processed foods and added sugars in the evening is particularly important, as late-night consumption forces the body to work against its natural rhythm.

Many people assume raw is always best, but certain vegetables actually become more nutritious when cooked, because heat breaks down cell walls, reduces antinutrients, or enhances bioavailability of key compounds. Here are the big ones:

Tomatoes

  • Nutrient Boosted: Lycopene (a powerful antioxidant linked to reduced risk of cancer and heart disease).

  • Why: Heat processing significantly increases lycopene bioavailability, even though vitamin C decreases.

  • Best Methods: Roasting, simmering into sauce, or slow cooking with olive oil (fat helps absorption).

Carrots

  • Nutrient Boosted: Beta-carotene (precursor to vitamin A, supports vision and immunity).

  • Why: Cooking breaks down tough cell walls, making beta-carotene up to 3x more available.

  • Best Methods: Steaming or roasting; avoid over-boiling which leaches nutrients into water.

Spinach, Kale, and Other Leafy Greens

  • Nutrient Boosted: Calcium, magnesium, and iron.

  • Why: Cooking reduces oxalates, compounds that block absorption of these minerals.

  • Best Methods: Light steaming or sautéing.

Asparagus

  • Nutrient Boosted: Ferulic acid and certain antioxidants.

  • Why: Heat releases more antioxidants from the cell walls.

  • Best Methods: Steaming or roasting.

Mushrooms

  • Nutrient Boosted: Antioxidants like ergothioneine and polyphenols.

  • Why: Heat amplifies antioxidant levels while preserving minerals.

  • Best Methods: Grilling or microwaving (boiling leaches nutrients).

Broccoli (and cruciferous family)

  • Mixed Bag: Vitamin C decreases with heat, but indole-3-carbinol and carotenoids become more available.

  • Pro Tip: Light steaming (not boiling) preserves sulforaphane, the anti-cancer compound.

Pumpkin & Winter Squash

  • Nutrient Boosted: Beta-carotene.

  • Why: Like carrots, cooking breaks down plant cell walls.

  • Best Methods: Baking or roasting.

 Rule of Thumb:

  • Steaming and roasting generally retain the most nutrients.

  • Boiling causes losses into the water (unless you drink it in soups/stews).

  • Pairing with healthy fats (olive oil, avocado, nuts) boosts absorption of fat-soluble vitamins (A, D, E, K).

As the old saying goes, and as modern science now validates:
“Eat breakfast like a king, lunch like a prince, and dinner like a pauper.”

Nutrition, Health, and Wellness

bookmark_borderGood Gut Bacteria (Gut Microbiome)

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by Daniel Brouse
help@membrane.com

Good Gut Bacteria
“Gut bacteria play several important roles in your health, such as communicating with your immune system and producing certain vitamins. Your gut bacteria can also affect how different foods are digested and produce chemicals….” (Why the Gut Microbiome Is Crucial for Your Health)

Most people start fermenting good gut bacteria from their mother’s breast milk. There are around 40 trillion bacterial cells in your body. They come from a wide variety of sources. One type can only be found in the milk or meat of cud chewing bovine. If your gut bacteria are destroyed, it is very difficult to re-establish. Eating and/or drinking probiotics will not in-and-of-itself re-establish good gut bacteria. COVID (and other conditions) destroys good gut bacteria resulting in a compromised immune system. The best way to re-establish your good gut bacteria is to consume breast milk for at least 6 months. Alternatively, you need to get all the right ingredients for fermentation including the proper 300 to 500 bacterial types, chemicals for the reaction, and lots of fiber.

Your gut bacteria changes throughout the day. The makeup of the bacteria cultures varies depending on what your body is doing. Eating, exercising, and sleeping will alter the good gut bacteria needed for the job. Changing your sleep schedule, or other changes to lifestyle, may result in noticeable changes in your digestion (runny stool to constipation.) Other reasons you may notice changes in your good gut bacteria activity include breaking down toxic food compounds or providing protection from pathogenic organisms (that enter the body through drinking or eating contaminated water or food.)

Vitamins
There is a symbiotic relationship between good gut bacteria and vitamins. “It has been known for decades that intestinal bacteria make important contributions to human metabolism and physiology. Perhaps the example best known to clinicians is the microbial synthesis of the essential nutrient vitamin B12 — the enzymes required for B12 synthesis are possessed by bacteria but not by plants or animals.” (Microbial production of vitamin B12)

Several bacterial genera that are common in the distal intestine (e.g., Bacteroides, Bifidobacterium, and Enterococcus) are known to synthesize vitamins. Thiamine, folate, biotin, riboflavin, and panthothenic acid are water-soluble vitamins that are plentiful in the diet, but that are also synthesized by gut bacteria. Likewise, it has been estimated that up to half of the daily Vitamin K requirement is provided by gut bacteria. Interestingly, the molecular structure of bacterially synthesized vitamins is not always identical to the dietary forms of the vitamins. In fact, several specialized epithelial transporters have been recognized to participate specifically in the absorption of vitamins derived from gut bacteria. (Contributions of Intestinal Bacteria to Nutrition and Metabolism in the Critically Ill)

Vitamin D and its nuclear receptor (VDR) regulate intestinal barrier integrity, and control innate and adaptive immunity in the gut. (Vitamin D and the Host-Gut Microbiome)

Sunlight and the photosynthesis of vitamin D also play an important and symbiotic role in maintaining good gut health.

Fiber
Soluble fiber benefits your digestion, gut bacteria, and blood sugar levels.

New knowledge about the gut microbiota and its interaction with the host’s metabolic regulation has emerged during the last few decades. Several factors may affect the composition of the gut microbiota, including dietary fiber. Dietary fiber is not hydrolyzed by human digestive enzymes, but it is acted upon by gut microbes, and metabolites like short-chain fatty acids are produced. The short-chain fatty acids may be absorbed into the circulation and affect metabolic regulation in the host or be a substrate for other microbes. (Dietary Fiber, Gut Microbiota, and Metabolic Regulation)

The best sources of dietary fiber are: beans, whole grains, brown rice, popcorn, nuts, baked potato with skin, berries, and bran cereal. Juicing and/or blending destroys most of the fiber.

A study “Cancer Prevention with Resistant Starch” (conducted over the last 30 years) shows that resistant starch reduces your risk of cancer. Good sources of resistant starch include rice or potatoes that have been cooked and cooled, as well as, whole grains such as barley and oats.

The resistant starches produce good bacteria that reduces a type of acid that promotes changes to your DNA. The changes to your DNA increase the risk of many types of cancer. The discovery may also explain in part why COVID increases your risk of cancer. COVID is known to destroy good gut bacteria.

Back to the NAD+ Immune Boosting Diet

bookmark_borderCOVID-19 Delta Variant and Vaccines

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COVID
By Daniel Brouse

What do we know about the Delta variant and vaccines?

OVERVIEW
The efficacy of mRna vaccines is about 79% against contracting the Delta variant. Non-mRna vaccines are between 40-60% effective against Delta. Vaccines lose efficacy at about 3%/month after six months of being fully vaccinated. Vaccines appear to help contain the Delta variant to the nasal passage. You are less likely to develop the epigenetic changes to your genes (long-COVID). Previous infection of COVID offers no protection to the Delta variant. Get vaccinated.

THE BAD NEWS
The delta variant is much more contagious than any other COVID strain. Vaccines also appear to be less effective at preventing infection from the Delta variant. On July 30, 2021, the Delta variant was much more predominant in Louisiana than in Pennsylvania. In Louisiana, 15% of the deaths were in vaccinated individuals. In Pennsylvania, 1% of the deaths were in vaccinated individuals.

Recent studies also revealed that vaccinated people can transmit the virus both asymptomatically and symptomatically.

THE GOOD NEWS
The vaccines are still tremendously effective at preventing infection, hospitalization and death from Delta.

Vaccinated individuals that get infected with Delta overwhelmingly stop the virus in their nasal passage. The virus never infects the lungs nor spreads to other systems causing blood clots or other life threatening conditions.

Since Delta never reaches the lungs and other organs, vaccinated people that test positive for COVID are unlikely to develop long-COVID (Long Haulers Syndrome). Long-COVID is caused by the coronavirus making epigenetic and genetic changes to your genes. COVID partially disables the immune system. Some of the dismantling is temporary lasting only a few days. Some of the dismantling is chronic and may last a lifetime.

The most common long term side-effect from COVID-19 are:
* the disruption of the body’s ability to produce and retain NAD+. Without NAD+ your immune system can not metabolize most vitamins, can not regulate body temperature, nor properly activate an immune response. Lack of NAD+ will cause your body to hi-jack tryptophan and cause all sorts-of mental and neurological disorders. Lack of NAD+ has been associated with over one hundred post-COVID ailments.
* upregulation of Indoleamine 2,3-dioxygenase (IDO). “IDO is an immune checkpoint molecule in the sense that it is an immunomodulatory enzyme produced by alternatively activated macrophages and other immunoregulatory cells. IDO is known to suppress T and NK cells, generate Tregs and myeloid-derived suppressor cells, and also supports angiogenesis.’

In the vast majority of cases, vaccinated individuals do not suffer from alterations to the genes. Vaccination almost always prevents Delta from developing into long-COVID’s Long Haulers Syndrome.

PROTECT YOUR GENES FROM THE VIRUS
GET VACCINATED
WEAR A MEDICAL GRADE MASK (to prevent the virus from getting in your nasal passage in the first place)
TAKE A NIACIN SUPPLEMENT
AVOID ANTI-VAXXERS LIKE THE PLAGUE

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

bookmark_borderLong-COVID and Environmental Aggravators

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by Daniel Brouse
help@membrane.com

Exercise aggravates long-COVID symptoms. COVID causes changes to your genes making it harder to create NAD+ and quicker to consume NAD+. Normally, exercise helps boost your NAD+. Not with long-COVID. The inflammation caused by exercise, anxiety, or exertion causes a rapid depletion of NAD+ aggravating long-COVID symptoms and perpetuating the downward cycle in NAD+ levels. So, Long Haulers should limit their activity until their NAD+ deficiency is under control.

What other factors can impact the severity of your long-COVID symptoms? We know anything that depletes NAD+ will cause problems. Aging, Hypertension, Obesity, Type 2 Diabetes, and other ailments result in suboptimal NAD+. But, what about your environment?

We know long term exposure to air pollution increases the risk of death from COVID-19 by 20 times. Another reason why wearing a mask in the out-of-doors is a good idea. Completely avoid outside exposure on air quality alert days.

I have been conducting research and development on two other environmental factors — elevation and temperature.

ELEVATION I — Change in Atmospheric Pressure
Elevation is the number of feet above sea level on which you stand. The bio-hacker experiment I’ve been conducting takes me from 400 feet above sea level to 1,400 feet above sea level. The more rapid the change from higher elevations to lower elevation, then the worse my long-COVID symptoms. All systems feel an impact; however, the middle ear takes the brunt of the punishment. Brain fog, dizziness, tinnitus, ear aches, vertigo, and pressure in the ears are all amplified in their severity. I just did a 24 hour experiment and am beginning to think it has to do with pressure. Perhaps O2 (oxygen in the blood) as well, but more to do with “atmospheric pressure and sea level.” The symptoms seem to lag behind the increase in pressure.

Dr. Ade Wentzel said, “The epigenetic upregulation of IDO will determine the amount of quinolinic acid. Quinolinic acid comes from the kynurenine pathway. If the viscosity of the whole middle ear is increased then the ability to equalize will be less… same as having a cold. So, the ear isn’t equalizing correctly on increasing pressure. The same as when you land in a plane. If the viscosity in the semicircular canals is increased, the otoliths may well be lagging causing the vertigo. The otoliths usually “Float” in the semicircular canal and trigger tiny sensory hairs that allow you to detect position.”

“IDO (Indoleamine 2,3-dioxygenase) is an immune checkpoint molecule in the sense that it is an immunomodulatory enzyme produced by alternatively activated macrophages and other immunoregulatory cells. IDO is known to suppress T and NK cells, generate Tregs and myeloid-derived suppressor cells, and also supports angiogenesis.’ (Wikipedia)

It is possible that changes in the weather that cause changes in atmospheric pressure (Lows and Highs) may result in the same problems. This happened to me with weather systems over the weekend (August 22, 2021.) A very low pressure system (hurricane Henri) passed by followed by a high pressure system. The following 2 days I suffered from brain fog, dizziness, tinnitus, ear aches, vertigo, and pressure in the ears.

ELEVATION II — Oxygen Desaturation
People that go to higher elevations — above 4,900 feet — start to have more problems with High Altitude Oxygenation. “High altitudes can cause low oxygen saturation levels or desaturation of an individual’s blood.” Changing elevations at higher than 4,900 feet might cause both oxygen desaturation and atmospheric pressure problems.

COVID causes a decrease in the “rate of oxygen uptake into the lung to the oxygen gradient between the capillary blood and the alveoli.” Dr. Ade Wentzel said, “We know that the Lung Diffusion co-efficient is increased [by optimizing NAD+ levels].”

TEMPERATURE
The sweet spot is between 50-70 degrees Fahrenheit. The further below 50 degrees the more severe the symptoms. Lower temperatures appear to be a linear relationship. On the other hand, temperatures above 70 degrees appear to have an exponential relationship. That is to say, if 80 degrees causes symptoms to be twice as bad, 90 degrees causes symptoms to be four times as severe.

CONCLUSION
Mountain hiking in 90 degree temperatures (exercise at higher elevations in the heat) causes unnecessary stress on your system and dramatically increases your chances of a negative outcome.

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

bookmark_borderPost-Acute COVID-19 — COVID Long Haulers Syndrome

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Guy A. Richards1, Adrian Wentzel2, Robert Miller

Post-Acute COVID-19 Sequelae
Post-Acute COVID-19 Sequelae


 

COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity Wentzel, Miller, Richards
COVID-19: NAD+ Deficiency by Wentzel, Miller, Richards (PDF)

Treatment of SARS-CoV-2 induced pneumonia with NAD+ in a mouse model Jiang, Deng, Ma, Pang, Hu, Qin, Xu
COVID-19 in Mice / NAD+ (PDF)

Post-Acute COVID-19 Sequelae

COVID Sequelae
COVID Sequelae

AIMMS seminar 23 June | Role of NAD+ in (long)Covid - Part 1: Prof. Guy Richards - Clinical perspective
AIMMS seminar 23 June | Role of NAD+ in (long)Covid – Part 1: Prof. Guy Richards – Clinical perspective

AIMMS seminar 23 June | Role of NAD+ in (long)Covid – Part 2: Dr. Ade Wentzel – Pathophysiology and Treatment of Long-Covid + Q&A

AIMMS seminar 23 June | Role of NAD+ in (long)Covid - Part 2: Dr. Ade Wentzel - Pathophysiology and Treatment of Long-Covid + Q&A
AIMMS seminar 23 June | Role of NAD+ in (long)Covid – Part 2: Dr. Ade Wentzel – Pathophysiology and Treatment of Long-Covid + Q&A

MORE ON COVID
The Vitamin Stack / Long Haulers Treatment

COVID-19 / SARS-CoV-2 / Novel Coronavirus

 

bookmark_borderCOVID-19: A Survivor’s Story

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by Daniel Brouse

(Also see the update: 3 Years of Living With It)

I am a scientist and journalist publishing articles and papers since 1994. As part of a collective of scientists, we have been working on the greatest threat to humankind — humans. Much of my effort has been spent on Anthropogenic Climate Change. In addition, I have specialized in pollution, diseases, health and wellness.

In late December 2019 and early January 2020, I started studying a novel coronavirus discovered in Wuhan, China. My first paper on the subject was published in March 2020 entitled “COVID-19 and Air Pollution”.

In late January of 2020, I had been very ill with an upper respiratory illness. The same illness killed my father. At the time, COVID-19 had not been known in the USA. Since there was no test for COVID, the doctors could not diagnose the specific virus that caused my father’s death. It wasn’t until my recurring symptoms were diagnosed as “COVID Long Haulers” in May of 2020 that I knew I was suffering the aftermath of COVID-19.

The recurring symptoms were so concerning that I devoted all of my resources to studying COVID-long and searching for a cure. Every couple of weeks I went through a wave of symptoms. Though not as severe as the original illness, the symptoms still would render me useless. The symptoms did not come on all at the same time, rather they would cycle through over two weeks (not necessarily in the same order) and then repeat. Exercise and exertion would cause the symptoms to be more severe. The symptoms included:

* difficulty breathing (feeling like you’re not taking in enough oxygen)
* congestion / mild cough
* stomach issues / diarrhea
* loss of taste, smell, and appetite
* temperature regulation / night sweats
* nightmares / vivid dreams
* dizziness / the spins / foggy thinking
* headaches / body aches / soreness
* fatigue
* ear aches
* peripheral neuropathy (tingling of the hands and feet)

My concerns were several. Would the symptoms go away over time? As the months went on, the answer was no. Would the long term recurrence of systems cause a permanent disability? The answer is probably yes. My organs were sustaining progressive damage. Respiratory, circulatory, neurological, and renal damage, as well as, blood clots, thinning and leaky blood vessels in the brain tissue, and death have all been attributed to COVID and COVID-long.

In my pursuit of answers, I found another long hauler scientist, Dr. Ade Wentzel. Ade proved to me that my hypothesis of “COVID-19 Long Haulers: autoimmune response due to inactive particles of the virus” was incorrect. Rather, he demonstrated that sars-cov-2 causes COVID-19 Induced Secondary Pellagra (CISP).

The main culprit is believed to be COVID’s genetic change to our production and utilization of NAD+ (nicotinamide adenine dinucleotide). NAD+ is involved in cell creation, maintenance, metabolism, and regulating cell processes. COVID can chronically increase the breakdown of NAD+ and simultaneously decrease the production of NAD+.

Ade added, “The biggest function of NAD+ is as a cofactor for energy(atp) production via the citric acid cycle. NAD+ is essential for carbohydrate metabolism. The brain being highly dependent on carbs.”

NAD+ and the Citric Acid Cycle
NAD+ and the Citric Acid Cycle

Ade introduced me to one of the co-authors of his research, Robert Miller. In October of 2020, Ade and Robert started me on “the stack”. The vitamin stack helps correct the NAD+ malady by treating COVID-19 Induced Secondary Pellagra. Finding the correct form and dosage of Niacin was the most challenging part.

Within days of starting the stack, my COVID-long symptoms dissipated. Since that time, I have remained relatively symptom free EXCEPT when I tried reducing the Niacin dosage. On three separate occasions, I experimented with reducing the dosage of Niacin. All three times my symptoms returned; therefore, I would call the stack a treatment not a cure.

Since that time, I have successfully helped thousands of other COVID-long victims with the stack.

At the end of April, I received my first dose of the Moderna vaccine. Loss of taste and muscle soreness symptoms returned for 24 hours and then disappeared. My overall wellness appears to have improved. Now, I’m experimenting with reducing my Niacin dosage again to see if the vaccine helped my body recover its ability to produce and retain NAD+.

After several days of reduced Niacin (nicotinic acid dosage was reduced from 300-500mg/day down to 0-30mg day), symptoms returned: neuropathy, fatigue, brain fog, muscle soreness, difficulty breathing, GI track / stomach issues, ear aches, and allergy-like symptoms. The most notable symptom to return — headaches. Prior to COVID, I did not experience headaches. Within days of decreasing the dosage, a chronic headache returned. I increased the Niacin dosage back to 500mg/day and supplemented the stack with resveratrol. Symptoms immediately dissipated.

After the second shot, side-effects were slightly worse. The metallic taste returned within a couple hours. For the 12-24 hours post-vaccination, there was dizziness, nausea, and fatigue. Then, all the side-effects disappeared. Three months after being fully vaccinated all of my presenting symptoms dissipated. Other “silent” post COVID conditions have persisted since the initial infection.

See the update: 3 Years of Living With It

CISP and The Stack

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

bookmark_borderCOVID-19 Testimonial Update — 1 Year Later

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January 19, 2021
Today is my one year anniversary of catching COVID-19.
* 24 hours later I started feeling weird — upset stomach and vertigo. Difficulty in falling to sleep with the “spins”.

* Woke up the next morning feeling like I had a severe hangover — headache, body ache, fatigue.

* 72 hours later I could not get out of bed and went 3 or 4 days without a memory.

* For the next 2 weeks I had severe symptoms including nightmares, night sweats, loss of smell and taste, difficulty breathing, cough, fatigue, muscle aches, and then finally diarrhea.

* On February 9, COVID took my father’s life.

* Over the next several months I noticed a recurring pattern of symptoms that would come in waves.

* On May 15, I was diagnosed with COVID Long Haulers Syndrome. My doctor informed me there was no known treatment.

* August of 2020, I met Dr. Ade Wentzel and debated the cause of long haulers — autoimmune response due to inactive particles of the virus Vs. COVID-19 Induced Secondary Pellagra (CISP). I started the Vitamin stack but was taking the wrong type of B3.

* October 15, 2020 I start taking the right type of B3 — nicotinic acid. Immediately, I was relieved of my severe symptoms.

* January 19, 2021:
I’m doing well. I keep pushing myself too hard and some mild symptoms return. Also, I tried reducing the nicotinic acid to 35mg a day and severe symptoms returned. So, I’m sticking to 400mg/day and trying not to push too hard. I am thinking there must be some serious long term cell damage?

The main mild symptom is GI related. Kind of hard to explain… sort-of a feeling of lack of control… like I might piss or poop my pants (but I don’t). I still get muscle soreness that seems more sore than I should from mild exertion. Of particular concern is my lower back and my kidneys.

I also seem to get partial night sweats. Unlike when I had COVID and got it all over my body, now it just happens to my head or parts of my body (last night it was behind my knees.) It’s weird… similar weirdness with my preexisting peripheral neuropathy. I’ve seen much improvement on the stack with virtually no pain nor pins-and-needles. But, sometimes pins-and-needles show up in parts of some fingers (not the entire hands and feet like before.) So, it seems the NAD+ regulation is not uniform over my entire body.

Overall I’m actually better than I was before getting COVID. However, when I tried reducing the nicotinic acid, I got diarrhea and headaches and fatigue (much more like when I was severe long hauling.) So, I guess I’m being treated but not cured. Now, I wonder if I will ever be cured?

Ade says, “You will be cured.” …and, is helping me tweak the Vitamin Stack.

Original COVID Testimonial

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

bookmark_borderGood Gut Bacteria

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Your good gut bacteria is essential to a healthy immune system. “The gut microbiota that resides in the gastrointestinal tract provides essential health benefits to its host, particularly by regulating immune homeostasis. Moreover, it has recently become obvious that alterations of these gut microbial communities can cause immune dysregulation, leading to autoimmune disorders.” [1]

Gut Bacteria Metabolic Activity and Vitamins
* Thiamine, folate, biotin, riboflavin, panthothenic acid are also synthesized by gut bacteria
* It has been estimated that up to half of the daily Vitamin K requirement is provided by gut bacteria
* B vitamins are synthesized by plants, yeasts, and bacteria… and their metabolized by intestinal bacteria

We also know: NAD+ controls the metabolism of Vitamin C and D.
* Autoimmune diseases tend to share a predisposition for vitamin D deficiency, which alters the microbiome and integrity of the gut epithelial barrier
* Metabolic syndrome can prompt imbalances in the gut microbiome, with impaired gut function contributing to toxins in the bloodstream, resulting in vitamin C depletion, which subsequently impairs the trafficking of vitamin E

Healthy Gut Bacteria and COVID-19
There is a connection between COVID-19 and healthy gut bacteria. A recent study demonstrated the connection between gut and SARS-CoV-2 virus’ however, it couldn’t be determined if the lack of healthy gut bacteria resulted in more severe COVID-19, or COVID-19 inhibited healthy gut bacteria. It is possible that both occur.

“Although COVID-19 is primarily a respiratory illness, there is mounting evidence suggesting that the GI tract is involved in this disease. We investigated whether the gut microbiome is linked to disease severity in patients with COVID-19, and whether perturbations in microbiome composition, if any, resolve with clearance of the SARS-CoV-2 virus.” [2]

NAD+ Plus Immune System Diet

1. The role of gut microbiota in immune homeostasis and autoimmunity (NIH)

2. Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19 (British Society of Gastroenterology)

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

bookmark_borderNAD+ Plus Immune System Diet (CISP CPD)

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By Daniel Brouse
help@membrane.com

THE NAD+ PLUS DIET (COVID Induced Secondary Pellagra and COVID Prevention Diet)

The NAD+ Plus Diet is based on research by Dr. Ade Wentzel (Port Elizabeth, South Africa), Robert Miller (Cape Town) and Guy Richards (Johannesburg). The team of scientist developed a diet based protocol that boosts NAD+ and the immune system.

THE PROTOCOL: Niacin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium

Boosting NAD+ is of particular importance when it comes to COVID-19. NAD+ (nicotinamide adenine dinucleotide) is in every cell of your body. NAD+ is involved in cell creation, maintenance, metabolism, and regulating cell processes. COVID both increases the breakdown of NAD+ and decreases the production of NAD+. If you have suboptimal NAD+ prior to contracting COVID, the coronavirus is likely to make the symptoms more severe and persist longer in duration (resulting in death.) Boosting your NAD+ can also help with aging, hypertension, type 2 diabetes, and most other ailments and illness.

By maintaining lifestyle and diet, COVID-19 can be prevented and/or shortened in severity and duration. COVID-long Haulers Syndrome can be cured. Long haulers syndrome is COVID-19 Induced Secondary Pellagra (CISP).

THE DIET TO BOOST THE IMMUNE SYSTEM WITH NAD+
Quercetin
Coffee and red wine are rich in Quercetin. Dieting can be fun. Quercetin is a bioflavonoid found in fruits and vegetables. There isn’t a Recommended Daily Allowance and the dosage depends on your weight; however, at least a 100mg per day is a good rule of thumb. 500-1000mg per day may be needed to boost NAD+. The highest levels are found in:

  • Onions 19.36mg per 100g serving [Red onion 32mg]
  • Dill (fresh) 55mg per 100g serving
  • Hot wax yellow peppers, raw 50mg per 100g serving
  • Radish leaves 70mg per 100g serving
  • Cilantro 53mg per 100g serving
  • Capers 173mg per 100g serving

Zinc
The Recommended Daily Allowance of Zinc is 10-15mg per day.

  • Water. Drinking water is rich in Zinc. Do not drink filtered water. Do not drink purified bottled water. Zinc is naturally present in water. The amount of Zinc in your water depends on the local geology and hydrologic cycle. The World Health Organization says, “In natural surface waters, the concentration of zinc is usually below 10 µg/litre, and in groundwaters, 10–40 µg/litre. In tapwater, the zinc concentration can be much higher as a result of the leaching of zinc from piping and fittings.” WARNING: If you live in an area where it is not safe to drink the water, or the zinc in the water is not sufficient, you may need to take a 10-15mg supplement.
    Nutrients In Drinking Water
    USDA Study shows regional mineral content of public and well water.
  • Meat and marine organisms contain 10–50 mg/kg wet weight

Vitamin C
The Recommended Daily Allowance of Vitamin C is 60mg per day. For NAD+ boosting, 500-1000mg may be required. Whole foods are recommended. Juicing may provide higher concentrations of Vitamin C; however, other nutritional benefits are lost in the process. You may need to supplement your diet with 500mg of Vitamin C per day.

  • Red pepper, sweet raw 95mg per 1/2 cup serving
  • Orange 70mg per serving
  • Broccoli cooked 39mg per 1/2 cup serving
  • Strawberries 49mg per 1/2 cup serving
  • Potato 17mg per 1/2 cup serving
  • Tomato 17mg mg per 1/2 cup serving

Vitamin D
The Recommended Daily Allowance of Vitamin D is 600-1,000iu per day. For NAD+ boosting, you may need to supplement your diet with 1,000-2,000iu of D3 per day. Few foods naturally contain vitamin D.

  • Sunlight. 15 minutes of sunshine per day. 90% of your body’s Vitamin D comes from the photosynthesis of sunlight to the skin. UVB light causes a reaction resulting in Vitamin D and other photoproducts essential for a healthy immune system. WARNING: UVB can cause cancer.
  • Fatty fish and seafood / Trout 645iu per serving
  • Mushrooms 366iu per 1/2 cup raw
  • Egg yolks 44iu per 1 scrambled egg
  • Fortified milk 120iu per cup

Selenium
The Recommended Daily Allowance of Selenium is 55mcg per day. Care should be taken not to overdose on Selenium. Consuming 50 Brazil nuts in one day can lead to selenosis resulting in breathing problems, heart attack, kidney failure, and death. Selenium supplements are not recommended.

  • Brazil nut 1 (one) 78mcg
  • Shrimp 3oz 40mcg
  • Chicken 3oz white meat 22mcg
  • Beef 3oz 18mcg

Niacin B3
The Recommended Daily Allowance of Niacin is 16mg per day. Niacin is your main precursor to creating NAD+. It is the most important component of the diet. It is also the most difficult to find sufficient quantities of in food. Most Americans get their Niacin from fortified breakfast cereal. Niacin is sprayed on the outside along with several other vitamins. It would take 100 bowls of Wheaties/day to correct a niacin deficiency. To obtain the amount of Niacin needed from a natural diet would require 4 pounds of liver a day or 62 pounds of cabbage (not recommended). You will likely need to supplement your diet with 50-100mg of Niacin per meal in order to boost your NAD+ and immune system. Nicotinic acid is essential, NOT nicotinamide.

  • Beef liver pan fried 3oz 15mg
  • Chicken breast 3oz 10mg
  • Marinara (spaghetti) sauce, ready to serve, 1 cup

Conclusion
Having survived COVID-19, I became inflicted with COVID-long Haulers Syndrome. After searching for a cause and a cure, I found The Vitamin and Mineral Protocol. The dosage depends on your age, weight, preexisting conditions, and what COVID has done to your body. The above diet is what cured me. You may need to increase the dosage of supplements.

COVID-19 Testimonial
Getting and Recovering from COVID.

The NAD+ Plus Immune Boosting Diet may treat other conditions. If you are on drugs to help regulate your preexisting conditions, you may need to reduce your dosage. Perhaps someone on Lisinopril for high blood pressure, or Warfarin to thin their blood, or maybe Metformin for their type 2 diabetes, should have concern that replenishing your NAD+ will cause the medication to be too strong. You should check with your doctor about lowering your dosage.

Robert Miller said, “Metaformin is a complex 1 inhibitor that will mess with NAD+ redox and NAD+ levels. As for lowering doses, yes, NAD+ boosting is highly likely to create a need to lower some medication but this must be done with a medical professional.”

Ade Wentzel added, “Quercetin and Warfarin should be monitored as the Warfarin effect may be changed. Nicotinic acid can reduce blood pressure and blood sugar in those with raised numbers so this needs to be monitored carefully.”

ADDITIONAL RESOURCES
COVID-19 / SARS-CoV-2 / Novel Coronavirus

COVID-19 Emergency Management Plan

COVID: The Cure?
Could Nicotinamide adenine dinucleotide (NAD+) be both a prophylactic and a treatment for COVID-19?

COVID-19: NAD+ Protocol
NAD+ is a crucial part of the immune system. COVID depletes your NAD+.
Included in the elements you need are Vitamin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium.

COVID Long Haulers Syndrome: NAD+ Deficiency
Research by Ade Wentzel, Robert Miller, and Guy Richards has found COVID-long (Long Haulers Syndrome) is a result of an NAD+ deficiency caused by SARS-CoV-2 (novel coronavirus).

bookmark_borderVitamin and Mineral Supplements

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In general, you should get your vitamins and minerals in the food you eat and water you drink as part of your natural diet.

It is difficult to find a multivitamin that is good for you. Taking metals, such as, Iron, Sodium, Magnesium, Potassium, or Calcium as a supplement can be dangerous. Usually Zinc is on the list; however, very controlled amounts of Zinc are recommended for NAD+ deficiencies. Metals are not good in supplements unless advised by a doctor to treat a specific condition. Besides being toxic in supplement form, supplements bypass the important parts of nutrition and the digestive process. For instance, “Fiber is incredibly important. It leaves your stomach undigested and ends up in your colon, where it feeds friendly gut bacteria, leading to various health benefits. Certain types of fiber may also promote weight loss, lower blood sugar levels, and fight constipation.”

You should get all your minerals from the food and water you intake. When you get your minerals from the food you eat, they are part of the metabolic process. The same holds true for hormones and amino acids. Don’t take the supplement. Let your body create them — melatonin, tryptophan, serotonin, Vitamin D. “Essential minerals are most potent when they come from food. But if you’re struggling with deficiencies, you may need to take supplements. If so, use caution: ingesting too much of a mineral supplement can be harmful.” — Harvard Health “Precious metals and other important minerals for health”

The exception to this rule is if you want to prevent COVID or recover from COVID-19. A safe and effective prophylactic to prevent COVID, a treatment for active COVID cases, and a protocol for post-COVID long haulers syndrome is available. The primary ingredient is Niacin B3.

THE PROTOCOL
Niacin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium.

The following doses have cured severe deficiencies in COVID-long cases:
* Vitamin C, Quercetin and Selenium you can get from your diet. Careful not too much Selenium. One (1) Brazil nut a day is adequate Selenium.
* The Vitamin D is best gotten from 15 minutes a day in the sun. You can take 1000iu/day supplement, too.
* A 15mg Zinc/day supplement. Care should be taken not to overdose on Zinc. There are many zinc products which deliver different amounts of free zinc per milligram.
* The Niacin is the trickiest and most important part. You need to make sure you get the right kind of B3. Non-flush is no good. You can start with 35mg/day, but it will depend on your deficiency. The cured long hauler takes 100mg with each meal. (For a 6 month duration.)

Niacin is the most important ingredient in the protocol. Niacin is used to replenish NAD+. The other ingredients can not be processed without NAD+. Taking mega doses of Vitamin C or Vitamin D are of little to no help without NAD+.

The protocol was developed by Dr. Ade Wentzel (Port Elizabeth, South Africa), Robert Miller (Cape Town) and Guy Richards (Johannesburg). They developed the diet based protocol as a result of their research COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity.

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus