Tag: immune system

bookmark_borderCOVID-19: Increased Risk of Autoimmune Diseases

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by Daniel Brouse

Not only is COVID-19 known to cause immune system disorders, post-COVID also increases the risk of autoimmune disease.

There are multiple ways COVID has been shown to weaken the immune system (Immunocompromised) including: Destruction of Good Gut Bacteria Resulting in a Compromised Immune System, Dysfunctional Kynurenine Pathway, Down Regulating NAD+, Up Regulating IDO, Rogue Antibodies, Exacerbates Underlying Conditions, and Post–COVID-19 Associated with Immune Cell Infiltration and Altered Gene Expression.

Autoimmunity does not mean the same thing as immunocompromised.   When you are immunocompromised, your immune system is under-performing.  If you are immunocompromised, you have a weakened immune system with a reduced ability to fight infections and other diseases. Autoimmune diseases are usually associated with an overactive immune system that mistakenly attacks healthy cells.  COVID can cause both immunocompromised conditions and autoimmunity diseases. “COVID-19 itself shares some similarities with systemic autoimmune rheumatic diseases, which could be a challenge for diagnostics.”

The matched cohort study Incident autoimmune diseases in association with a SARS-CoV-2 infection found:
Incident autoimmune diseases in association with a SARS-CoV-2 infection
“We found a 42.63% higher likelihood of acquiring autoimmunity for patients who had suffered from COVID-19.”

Conclusions SARS-CoV-2 infection is associated with an increased risk of developing new-onset autoimmune diseases after the acute phase of infection.

A study published in the journal Lancet Risk of autoimmune diseases in patients with COVID-19 found:

“After matching, the COVID-19 cohort exhibited significantly higher risks of rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, dermatopolymyositis, systemic sclerosis, Sjögren’s syndrome, mixed connective tissue disease, Behçet’s disease, polymyalgia rheumatica, vasculitis, psoriasi, inflammatory bowel disease, celiac disease, type 1 diabetes mellitus and mortality.”

The study, titled “Iron Dysregulation and Inflammatory Stress Erythropoiesis Associated with Long-Term Outcome of COVID-19,” reveals that Long-COVID is linked to elevated levels of C-reactive protein and prolonged elevation of cytokines compared to healthy controls. Iron dysregulation is a common occurrence after infections, as the body swiftly moves iron out of the bloodstream to prevent it from becoming a potential breeding ground for harmful bacteria. The study suggests that defects in iron homeostasis, dysregulated erythropoiesis, and immune dysfunction resulting from COVID-19 may contribute to inefficient oxygen transport, inflammatory imbalances, and persistent symptoms. The information on autoimmune diseases emphasizes that an excessive release of cytokines, which are signaling molecules involved in immune responses, can lead to an exaggerated inflammatory response. This heightened inflammation has the potential to damage tissues and contribute to autoimmune diseases, where the immune system mistakenly attacks healthy cells.

The study: Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19

Also see: COVID-19 Compromises Your Immune System (Immunocompromised)

COVID-19 Index

bookmark_borderCOVID-19 Compromises Your Immune System (Immunocompromised)

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By Daniel Brouse

SARS-CoV-2 and the results of COVID-19 cause long-term immune system dysfunction. That is to say COVID results in a compromised immune system.

* SARS-CoV-2 infection weakens immune-cell response
The magnitude and quality of a key immune cell’s response to vaccination with two doses of the Pfizer-BioNTech COVID-19 vaccine were considerably lower in people with prior SARS-CoV-2 infection compared to people without prior infection, a study has found. In addition, the level of this key immune cell that targets the SARS-CoV-2 spike protein was substantially lower in unvaccinated people with COVID-19 than in vaccinated people who had never been infected. Importantly, people who recover from SARS-CoV-2 infection and then get vaccinated are more protected than people who are unvaccinated. These findings suggest that the virus damages an important immune-cell response.

* Destruction of Good Gut Bacteria Resulting in a Compromised Immune System
Gut microbiome composition was significantly altered in patients with COVID-19 compared with non-COVID-19 individuals.

* Dysfunctional Kynurenine Pathway
“Targeted and untargeted metabolomics analyses identified altered tryptophan metabolism into the kynurenine pathway, which regulates inflammation and immunity.”

* Down Regulating NAD+
“NAD regulates the inflammatory response in immune and non-immune cells through Sirtuins. Epigenetic regulation of histones and non-histone proteins is induced by sirtuins and is essential for the development, reprogramming, and differentiation of the immune system and its related pathologies. A deregulation of the NAD+ levels has been associated with metabolic diseases and aging-related diseases, including neurodegeneration, defective immune responses, and cancer.”

* Up Regulating IDO
Indoleamine 2,3-dioxygenase (IDO) is an immune checkpoint molecule in the sense that it is an immunomodulatory enzyme produced by alternatively activated macrophages and other immunoregulatory cells. IDO is known to suppress T and NK cells, generate Tregs and myeloid-derived suppressor cells, and also supports angiogenesis.

* Rogue Antibodies
Autoantibodies are antibodies (immune proteins) that mistakenly attack a person’s own healthy tissues and organs. SARS-CoV-2 infection, is associated with many different clinical features that are commonly found in autoimmune diseases, including arthralgias, myalgias, fatigue, sicca, and rashes.

* Dysregulation of the innate immune system, i.e. “cytokine storm”
It is important to note that the severity of disease in humans is not determined only by virus replication but also by the host immune response to the infection, which may lead to dysregulation of the innate immune system, i.e. “cytokine storm” (Omicron SARS-CoV-2 can infect faster and better)

* Reinfection Greater Risks & Exacerbates Underlying Conditions
The evidence shows that reinfection further increases risks of death, hospitalization and damage to multiple organ systems. COVID exacerbates underlying conditions including pulmonary, cardiovascular, hematological, diabetes, gastrointestinal, kidney, mental heal<th, musculoskeletal and neurological disorders

* Post–COVID-19 Associated with Immune Cell Infiltration and Altered Gene Expression
COVID causes long-term immune dysfunction. “These findings indicate that T cell–mediated inflammation persists in the olfactory epithelium long after SARS-CoV-2 has been eliminated from the tissue, suggesting a mechanism for long-term post–COVID-19 smell loss.”

* Elevated Cytokines and Low Iron
Defects in iron homeostasis, dysregulated erythropoiesis contribute to inefficient oxygen transport, inflammatory imbalances, and persistent symptoms. The information on autoimmune diseases emphasizes that an excessive release of cytokines, which are signaling molecules involved in immune responses, can lead to an exaggerated inflammatory response. This heightened inflammation has the potential to damage tissues and contribute to autoimmune diseases, where the immune system mistakenly attacks healthy cells.

Also see: COVID-19: Increased Risk of Autoimmune Diseases

COVID-19 Index

bookmark_borderPollen and Increased SARS-CoV-2 Infection Rates

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The Proceedings of the National Academy of Sciences of the United States of America published the study Higher airborne pollen concentrations correlated with increased SARS-CoV-2 infection rates, as evidenced from 31 countries across the globe.

The research showed that airborne pollen on average accounts for 44% of the variation in infection rates in addition to humidity and air temperature.

Pollen exposure weakens the immunity by diminishing the antiviral interferon response.

“Our large-scale retrospective data analysis based on 80 individual time series from 130 regions in 31 countries in all inhabited continents across the globe (8,019 data points) enabled us to reveal a robust and significant positive correlation between SARS-CoV-2 infection rates and airborne pollen concentrations, which was halved under lockdown.”

COVID-19 and Air Pollution

COVID-19 Index

bookmark_borderCOVID Immunity: What We Know

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1) Natural Immunity
If you get a moderate to severe case of COVID-19, most people maintain viable antibodies for 90 days and memory T-cells for 5 months. This will likely give you natural immunity to the same strain of COVID for up to 5 months. The resistance to the UK variant is thought to be diminished. The resistance to the South African variant is thought to be none. There is some concern that COVID may erase all or part of your T cells’ memory for other pathogens.

2) Vaccines
You should anticipate that vaccines will give you a very similar immune response as the natural immunity acquired from contracting COVID. It doesn’t matter which vaccine you receive. You should get whatever vaccine you can get and as soon as possible. You should anticipate needing to get vaccinated every 90 days once vaccines are developed for all the different variants.

The message is — we have to stop the community spread and exponential rise in variants WORLDWIDE. Individual countries can not obtain herd immunity.

More Information on COVID-19

bookmark_borderGood Gut Bacteria

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Your good gut bacteria is essential to a healthy immune system. “The gut microbiota that resides in the gastrointestinal tract provides essential health benefits to its host, particularly by regulating immune homeostasis. Moreover, it has recently become obvious that alterations of these gut microbial communities can cause immune dysregulation, leading to autoimmune disorders.” [1]

Gut Bacteria Metabolic Activity and Vitamins
* Thiamine, folate, biotin, riboflavin, panthothenic acid are also synthesized by gut bacteria
* It has been estimated that up to half of the daily Vitamin K requirement is provided by gut bacteria
* B vitamins are synthesized by plants, yeasts, and bacteria… and their metabolized by intestinal bacteria

We also know: NAD+ controls the metabolism of Vitamin C and D.
* Autoimmune diseases tend to share a predisposition for vitamin D deficiency, which alters the microbiome and integrity of the gut epithelial barrier
* Metabolic syndrome can prompt imbalances in the gut microbiome, with impaired gut function contributing to toxins in the bloodstream, resulting in vitamin C depletion, which subsequently impairs the trafficking of vitamin E

Healthy Gut Bacteria and COVID-19
There is a connection between COVID-19 and healthy gut bacteria. A recent study demonstrated the connection between gut and SARS-CoV-2 virus’ however, it couldn’t be determined if the lack of healthy gut bacteria resulted in more severe COVID-19, or COVID-19 inhibited healthy gut bacteria. It is possible that both occur.

“Although COVID-19 is primarily a respiratory illness, there is mounting evidence suggesting that the GI tract is involved in this disease. We investigated whether the gut microbiome is linked to disease severity in patients with COVID-19, and whether perturbations in microbiome composition, if any, resolve with clearance of the SARS-CoV-2 virus.” [2]

NAD+ Plus Immune System Diet

1. The role of gut microbiota in immune homeostasis and autoimmunity (NIH)

2. Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19 (British Society of Gastroenterology)

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

bookmark_borderNAD+ Plus Immune System Diet (CISP CPD)

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By Daniel Brouse
help@membrane.com

THE NAD+ PLUS DIET (COVID Induced Secondary Pellagra and COVID Prevention Diet)

The NAD+ Plus Diet is based on research by Dr. Ade Wentzel (Port Elizabeth, South Africa), Robert Miller (Cape Town) and Guy Richards (Johannesburg). The team of scientist developed a diet based protocol that boosts NAD+ and the immune system.

THE PROTOCOL: Niacin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium

Boosting NAD+ is of particular importance when it comes to COVID-19. NAD+ (nicotinamide adenine dinucleotide) is in every cell of your body. NAD+ is involved in cell creation, maintenance, metabolism, and regulating cell processes. COVID both increases the breakdown of NAD+ and decreases the production of NAD+. If you have suboptimal NAD+ prior to contracting COVID, the coronavirus is likely to make the symptoms more severe and persist longer in duration (resulting in death.) Boosting your NAD+ can also help with aging, hypertension, type 2 diabetes, and most other ailments and illness.

By maintaining lifestyle and diet, COVID-19 can be prevented and/or shortened in severity and duration. COVID-long Haulers Syndrome can be cured. Long haulers syndrome is COVID-19 Induced Secondary Pellagra (CISP).

THE DIET TO BOOST THE IMMUNE SYSTEM WITH NAD+
Quercetin
Coffee and red wine are rich in Quercetin. Dieting can be fun. Quercetin is a bioflavonoid found in fruits and vegetables. There isn’t a Recommended Daily Allowance and the dosage depends on your weight; however, at least a 100mg per day is a good rule of thumb. 500-1000mg per day may be needed to boost NAD+. The highest levels are found in:

  • Onions 19.36mg per 100g serving [Red onion 32mg]
  • Dill (fresh) 55mg per 100g serving
  • Hot wax yellow peppers, raw 50mg per 100g serving
  • Radish leaves 70mg per 100g serving
  • Cilantro 53mg per 100g serving
  • Capers 173mg per 100g serving

Zinc
The Recommended Daily Allowance of Zinc is 10-15mg per day.

  • Water. Drinking water is rich in Zinc. Do not drink filtered water. Do not drink purified bottled water. Zinc is naturally present in water. The amount of Zinc in your water depends on the local geology and hydrologic cycle. The World Health Organization says, “In natural surface waters, the concentration of zinc is usually below 10 µg/litre, and in groundwaters, 10–40 µg/litre. In tapwater, the zinc concentration can be much higher as a result of the leaching of zinc from piping and fittings.” WARNING: If you live in an area where it is not safe to drink the water, or the zinc in the water is not sufficient, you may need to take a 10-15mg supplement.
    Nutrients In Drinking Water
    USDA Study shows regional mineral content of public and well water.
  • Meat and marine organisms contain 10–50 mg/kg wet weight

Vitamin C
The Recommended Daily Allowance of Vitamin C is 60mg per day. For NAD+ boosting, 500-1000mg may be required. Whole foods are recommended. Juicing may provide higher concentrations of Vitamin C; however, other nutritional benefits are lost in the process. You may need to supplement your diet with 500mg of Vitamin C per day.

  • Red pepper, sweet raw 95mg per 1/2 cup serving
  • Orange 70mg per serving
  • Broccoli cooked 39mg per 1/2 cup serving
  • Strawberries 49mg per 1/2 cup serving
  • Potato 17mg per 1/2 cup serving
  • Tomato 17mg mg per 1/2 cup serving

Vitamin D
The Recommended Daily Allowance of Vitamin D is 600-1,000iu per day. For NAD+ boosting, you may need to supplement your diet with 1,000-2,000iu of D3 per day. Few foods naturally contain vitamin D.

  • Sunlight. 15 minutes of sunshine per day. 90% of your body’s Vitamin D comes from the photosynthesis of sunlight to the skin. UVB light causes a reaction resulting in Vitamin D and other photoproducts essential for a healthy immune system. WARNING: UVB can cause cancer.
  • Fatty fish and seafood / Trout 645iu per serving
  • Mushrooms 366iu per 1/2 cup raw
  • Egg yolks 44iu per 1 scrambled egg
  • Fortified milk 120iu per cup

Selenium
The Recommended Daily Allowance of Selenium is 55mcg per day. Care should be taken not to overdose on Selenium. Consuming 50 Brazil nuts in one day can lead to selenosis resulting in breathing problems, heart attack, kidney failure, and death. Selenium supplements are not recommended.

  • Brazil nut 1 (one) 78mcg
  • Shrimp 3oz 40mcg
  • Chicken 3oz white meat 22mcg
  • Beef 3oz 18mcg

Niacin B3
The Recommended Daily Allowance of Niacin is 16mg per day. Niacin is your main precursor to creating NAD+. It is the most important component of the diet. It is also the most difficult to find sufficient quantities of in food. Most Americans get their Niacin from fortified breakfast cereal. Niacin is sprayed on the outside along with several other vitamins. It would take 100 bowls of Wheaties/day to correct a niacin deficiency. To obtain the amount of Niacin needed from a natural diet would require 4 pounds of liver a day or 62 pounds of cabbage (not recommended). You will likely need to supplement your diet with 50-100mg of Niacin per meal in order to boost your NAD+ and immune system. Nicotinic acid is essential, NOT nicotinamide.

  • Beef liver pan fried 3oz 15mg
  • Chicken breast 3oz 10mg
  • Marinara (spaghetti) sauce, ready to serve, 1 cup

Conclusion
Having survived COVID-19, I became inflicted with COVID-long Haulers Syndrome. After searching for a cause and a cure, I found The Vitamin and Mineral Protocol. The dosage depends on your age, weight, preexisting conditions, and what COVID has done to your body. The above diet is what cured me. You may need to increase the dosage of supplements.

COVID-19 Testimonial
Getting and Recovering from COVID.

The NAD+ Plus Immune Boosting Diet may treat other conditions. If you are on drugs to help regulate your preexisting conditions, you may need to reduce your dosage. Perhaps someone on Lisinopril for high blood pressure, or Warfarin to thin their blood, or maybe Metformin for their type 2 diabetes, should have concern that replenishing your NAD+ will cause the medication to be too strong. You should check with your doctor about lowering your dosage.

Robert Miller said, “Metaformin is a complex 1 inhibitor that will mess with NAD+ redox and NAD+ levels. As for lowering doses, yes, NAD+ boosting is highly likely to create a need to lower some medication but this must be done with a medical professional.”

Ade Wentzel added, “Quercetin and Warfarin should be monitored as the Warfarin effect may be changed. Nicotinic acid can reduce blood pressure and blood sugar in those with raised numbers so this needs to be monitored carefully.”

ADDITIONAL RESOURCES
COVID-19 / SARS-CoV-2 / Novel Coronavirus

COVID-19 Emergency Management Plan

COVID: The Cure?
Could Nicotinamide adenine dinucleotide (NAD+) be both a prophylactic and a treatment for COVID-19?

COVID-19: NAD+ Protocol
NAD+ is a crucial part of the immune system. COVID depletes your NAD+.
Included in the elements you need are Vitamin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium.

COVID Long Haulers Syndrome: NAD+ Deficiency
Research by Ade Wentzel, Robert Miller, and Guy Richards has found COVID-long (Long Haulers Syndrome) is a result of an NAD+ deficiency caused by SARS-CoV-2 (novel coronavirus).

bookmark_borderCOVID-19 Long Haulers Syndrome and NAD+ Deficiency

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COVID
by Daniel Brouse
Email: help@membrane.com

Research by Ade Wentzel, Robert Miller, and Guy Richards has found COVID-long (Long Haulers Syndrome) is a result of an NAD+ deficiency caused by SARS-CoV-2 (novel coronavirus). [1] The study Treatment of SARS-CoV-2 induced pneumonia with NAD+ in a mouse model confirms the team’s findings. “Our in vivomouse study supports trials for treating COVID-19 patients with NAD+ or its precursors.” [2] The onset of symptoms in “waves” over a period of weeks is likely secondary to exercise (probably consumption of NAD+.)

Nicotinamide adenine dinucleotide (NAD+) is an essential part of the body’s immune system. NAD+ is involved in cell creation, maintenance, metabolism, and regulating cell processes. COVID both increases the breakdown of NAD+ and decreases the production of NAD+.

Long haulers’ symptoms can be traced to a lack of the NAD+ building blocks, as well as, unregulated NAD+ cell processes.

Pellagra = NAD+ and tryptophan deficiency (nicotinic acid, niacin)
Breast = oxytocin
BP = vasopressin
Serotonin = tryptophan
Muscle cramps = calcium metabolism

A COVID NAD+ deficiency can cause a lack of serotonin regulation resulting in a lack of body temperature regulation. Ade Wentzel said, “NAD+ deficiency causes a lack of Tryptophan which is used for serotonin production and hence temperature… really the same as pellagra. The brain fog is part of low NAD+ and tryptophan. [3] If you have a NAD+ deficiency before contracting COVID, it could kill you.” Pellagra is a multiple-deficiency disease associated with diets providing low levels of niacin and/or tryptophan and often involving other B vitamins resulting in changes in the skin, gastrointestinal tract, and nervous system. Skin lesions, gastrointestinal lesions (including nausea, excessive salivation, a burning sensation in the epigastrium, and diarrhoea), and nervous lesions (including anxiety, depression, and fatigue; later symptoms include apathy, headache, dizziness, irritability and tremors) are all symptoms of pellagra and CISP (Covid Induced Secondary Pellagra). [4}

PROTOCOL
At this point in time, the safest and most effective treatment is to replenish the body’s NAD+. The most important building block is Niacin (B3). Care should be taken in obtaining the correct kind of B3. Robert Miller offered, “Avoid Inositol Nicotinate (non-flushing B3).” Ade added, “We suggest you use nicotinic acid (niacin B3). We also believe it works most directly to increase NAD+. Niacin doesn’t cause liver problems. Non-flush niacin does though.” (Robert and Ade’s Guide to Niacin)

“Some people respond really quickly to the protocol, and some really slowly needing bigger nicotinic acid doses. Different symptoms respond at different speeds. You may have to supplement for 6 months still,” notes Ade.

The complete Miller/Wentzel/Richards “COVID NAD+ protocol” to correct a NAD+ deficiency:
NAD+ = nicotinic acid (niacin B3), Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus
1. COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity Wentzel, Miller, Richards
COVID-19: NAD+ Deficiency by Wentzel, Miller, Richards (PDF)

2. Treatment of SARS-CoV-2 induced pneumonia with NAD+ in a mouse model Jiang, Deng, Ma, Pang, Hu, Qin, Xu
COVID-19 in Mice / NAD+ (PDF)

3. Joseph Goldberger’s research on the prevention of pellagra Alfredo Morabia

4. PELLAGRA and its prevention and control in major emergencies WHO
Pellagra Prevention and Control

bookmark_borderInterferons Interfere With Disease

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by Daniel Brouse

An interferon is a protein released by animal cells, usually in response to the entry of a virus, which has the property of inhibiting virus replication. A natural substance that helps the body’s immune system fight infection and other diseases, such as cancer. Interferons are made in the body by white blood cells and other cells, but they can also be made in the laboratory to use as treatments for different diseases. In cancer therapy, interferons may help keep cancer cells from growing and may help kill cancer cells. There are three main types of interferons: interferon-alfa, interferon-beta, and interferon-gamma. An interferon is a type of cytokine and type of immunomodulating agent. [1]

Several new studies of immune response to SARS-CoV-2, the virus that causes the disease, suggest timing could be critical for interferons. These immune proteins suppress viral replication early in disease. Yet if they are active later, some scientists think they can exacerbate the harmful inflammation that forces some COVID-19 patients onto life support. Interferons are “a double-edged sword,” says immunologist Eui-Cheol Shin of the Korea Advanced Institute of Science and Technology. [2]

The timing of the creation and the implementation of interferons appears to be a critical part of the immune system. Synthetic interferons may do more harm than good. Synthesizing and synergizing interferons by the body may be a safe and effective way to boost the nonspecific immune system. It may also be a safe and effective way to boost the specific immune system.

Memory T cells are created when a naive T cell acquires the memory of an antigen. Acquired T cell responses are critical for the host’s defense against microbial pathogens. T cells, by the release of interferon-γ (IFN-γ), induce autophagy, phagosomal maturation, the production of antimicrobial peptides such as cathelicidin, and antimicrobial activity. There is a a mechanism in which vitamin D is required for acquired immunity to overcome the ability of intracellular pathogens to evade macrophage-mediated antimicrobial responses.[3]

While the inflammation generated by innate immune cells [neutrophils, macrophages, monocytes, natural killer (NK) cells, dendritic cells (DCs), etc.] is important in the initial containment of the infection, it also informs and directs the expansion and differentiation of adaptive immune cells. Responding to the inflammatory environment created by the innate response, cells of the adaptive arm of the immune response (B cells, αβ T cells, and γδ T cells) are stimulated to expand in number (proliferate) and to differentiate into cells with a range of functions appropriate for the immunological challenge.[4]

What is necessary for the creation and implementation of interferons?

The role of eating meat in your diet is not yet clearly known; however, animal proteins and amino acids obtained through eating meat likely play an important role in creating interferons. We do know that bacterium found in ruminant cattle (meat and milk) is essential for humans to make Vitamin D. [5] We also know that exposure of the skin to sunlight (UVB radiation) is required for the body to photosynthesize Vitamin D and create the photoproducts. Previtamin D3 and vitamin D3 also absorb UV B radiation and are converted into a variety of photoproducts some of which have unique biologic properties. [6]

“We’ve discovered a new component of the interferon system,” said Michael J. Holtzman, MD, the Selma and Herman Seldin Professor of Medicine. “It does something that other components don’t do, and it works on both sides of the fence: It dials up the body’s internal genes that fight viruses, and it attacks viral proteins directly.”

The researchers’ strategy did not involve increasing the amount of interferon, the first step of this important antiviral signaling cascade. Instead, it dialed up amounts of the protein STAT1, the second component of this cascade, without altering the system’s overall interferon on/off switch.

“Past work to boost this system just kept the interferon signal on all the time,” Holtzman said. “When the system is chronically activated, it is no longer regulated, and that’s where the autoimmune problems may come from. Our system is still regulated by the presence or absence of interferon. Interferon amounts increase when there is an infection and decrease when there is no infection. We’re not boosting interferon itself, but the secondary signal that interferon activates, which sets off the rest of the antiviral cascade. It’s like greasing the wheels. We’re not pushing the system any harder. But when we do push, we get a bigger effect.” [7]

COVID, Vitamin D, Health, and Wellness

Vitamin D, Sunlight, the Season, and People of Color

Your Immune System and Photosynthesized Vitamin D

1. Interferon National Cancer Institute
2. An Immune Protein Could Prevent Severe COVID-19—if It Is Given at the Right Time Scientific American
3. Vitamin D Is Required for IFN-γ–Mediated Antimicrobial Activity of Human Macrophages NIH
4. T cell responses: naïve to memory and everything in between NIH
5. Dr. Karl Kruszelnicki Podcast / Australian Broadcasting Corporation

6. Sunlight and Vitamin D NIH
7. Study reveals new, potent way to boost immunity and fight viruses​​​ Washington University in St.Louis

bookmark_borderOmnivores: About Your Immune System and COVID

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By Daniel Brouse

Humans are omnivores. A human’s immune system is dependent on eating an omnivore’s diet. Your immune system is really a collaboration between many of your body’s systems, such as, neurological, respiratory, cardiovascular, and circulatory systems. The “health” of your immune system is dependent on your overall status, but more importantly, the ability of your immune system to respond to any given battle at a particular time.

COVID can cause damage to your organs directly during the fight. COVID can also cause damage to all your body’s systems. Post-COVID chronic ailments comprise both categories. Many COVID cases result in damage to the lungs, heart, kidneys, and brain. Many COVID cases also cause damage to your immune system. (eg Long Haulers Syndrome)

Diet and lifestyle choices are detrimental in both the immune system’s ability to fight individual battles, as well as, your immune system’s ability to survive the war.

THE BATTLE
When an infection starts attacking your body, your immune system starts a process involving most of your body’s systems including neurological, respiratory, cardiovascular, and circulatory systems. Your brain connects with command centers throughout your body. The power supply for these command centers is called NAD+

The timing and locations of the battles are crucial for victory. Your command centers deploy Trojan horses to the nearest fight. The Trojan horses come in a variety of different breeds but are commonly called interferons. The interferons are unique antiviral proteins. They are part of the process that invades the infection, gets inside, steals the memory. Then, the interferon creates more protein. The proteins prevent the virus from multiplying. To help you win the war, the memory of the virus is then transferred to your central intelligence agency and used in your antibody production including T-cells and B-cells.

Your immunity factory needs a bunch of supplies to metabolize in order to win. It is critical that your body make and distribute the supplies to the immune factory assembly line. Supplements may be substituted in an emergency, but supplements can not replace your assembly line. You need to consume plants, animals, O2, H20, and sunlight. Time is of the essence.

WINNING THE BATTLE AGAINST COVID
The simplest strategy to defeat COVID is to consume Niacin (B3) and photosynthesized Vitamin D (sunlight).

Niacin is crucial for the production of your command centers — Nicotinamide adenine dinucleotide (NAD+)

Sunlight is crucial for the production of your interferons. The photosynthesis of Vitamin D produces the Vitamin D you need, but more important for this battle is the timing of the unique photoproducts that are also created in the photosynthesis process — interferons. The interferons need to be deployed rapidly to the exact location of the intruder. In the end, interferons are meat proteins consumed by your immune system. The role of eating meat in your diet is not yet clearly known; however, animal proteins and amino acids obtained through eating meat likely play an important role. We do know that bacterium found in ruminant cattle (meat and milk) is essential for humans to make Vitamin D.

CONCLUSION
To help prevent catching COVID, to help fight COVID, and/or to recover from post-COVID, Niacin and the photosynthesis of Vitamin D are the simplest protocol.

bookmark_borderCOVID: Treatment?

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By Daniel Brouse

COVID
COVID

This is an interview with Ade Wentzel. Ade is a doctor and scientist working with COVID hospitals. I met Ade in a COVID survivors group. Though I did not know it at the time, I survived COVID in February of 2020. It was only months later that I figured out something was wrong with me. Even though I had been isolating since February, I kept getting sick. After a month of scientific research, I was diagnosed with Long Haulers Syndrome.

I had come to the conclusion that my long haulers was caused by lots of little cytokine storms. During a heated debate with a COVID antigen scientist from Spain that is researching for Johns Hopkins, Ade joined the conversation. The Johns Hopkins scientist took issue with the words “cytokine storms”. A cytokine storm is defined as a single large event. Ade helped me come to the conclusion that I was having cytokine disfunctions.

We do know that the virus consumes NAD+ because various studies have measured it. We do know that NAD+ and zinc are needed for SIRT1 activation. We also know that SIRT 1 downregulates TACE and hence downregulates TNFa and hence IL6.

Possibly for the longhaulers it’s cytokine imbalance or just NAD+ deficiency. The symptomatology improves vastly with NAD+ precursors but if cellular damage or organ damage is to occur, this takes time.

I do agree the term cytokine storm for long haulers is very incorrect, but an autoimmune disconnect seems more appropriate.
— Ade Wentzel

Ade referred me to a research paper: COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity. It took me several months to figure out that Ade is a co-author of the research. During this time, I embraced “Ade’s Protocol”: Vitamin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium.

INTERVIEW WITH ADE
Do you think you are cured of your long haulers? Do you think it is likely you may have other long term damage that you are not yet aware of?
Ade: So I am probably one of the longest around 6 Dec 2019 and am 99.5% back to normal.

We set out to investigate how to do the above, change risk, and of the about 3500 on a prophylactic regime only 1 person has been positive and had multiple exposures running a covid hospital. His course proved to be mild.

As a clinician I am super scared of such anecdotal evidence and a trial is really the only way to gain exposure and traction.

Am I worried about long term damage that I may not be aware of? No…if it raises its head I will deal with it then.

We never set out to chase the virus, but only to save 1 person….and that we have done. It’s been a team approach with Robert Miller
who first noticed the NAD+ link and Prof Guy A. Richard’s who guided, scrutinized, questioned and encouraged the clinical process.

In my humble opinion, you guys should get the Nobel Prize. I knew the protocol was working on my long haulers, but wasn’t sure if you thought it was a prophylactic, too. And, I’m guessing it might also be a “treatment” for active COVID cases?
Ade: it works wonders for all 3. Pre, during and after and for post covid anxiety.We started with pre covid prophylaxis on a small 250 strong group in Ireland who were then starting to peak and at 3 care centers in the UK all on a voluntary basis. Then, progressed to acute patients. Through this process I was a long hauler who had access to all specialties to discuss our research and often going on to treat them when they became unwell.

COVID NAD+ Deficiency

COVID-19 Index