bookmark_borderInterferons Interfere With Disease

by Daniel Brouse

An interferon is a protein released by animal cells, usually in response to the entry of a virus, which has the property of inhibiting virus replication. A natural substance that helps the body’s immune system fight infection and other diseases, such as cancer. Interferons are made in the body by white blood cells and other cells, but they can also be made in the laboratory to use as treatments for different diseases. In cancer therapy, interferons may help keep cancer cells from growing and may help kill cancer cells. There are three main types of interferons: interferon-alfa, interferon-beta, and interferon-gamma. An interferon is a type of cytokine and type of immunomodulating agent. [1]

Several new studies of immune response to SARS-CoV-2, the virus that causes the disease, suggest timing could be critical for interferons. These immune proteins suppress viral replication early in disease. Yet if they are active later, some scientists think they can exacerbate the harmful inflammation that forces some COVID-19 patients onto life support. Interferons are “a double-edged sword,” says immunologist Eui-Cheol Shin of the Korea Advanced Institute of Science and Technology. [2]

The timing of the creation and the implementation of interferons appears to be a critical part of the immune system. Synthetic interferons may do more harm than good. Synthesizing and synergizing interferons by the body may be a safe and effective way to boost the nonspecific immune system. It may also be a safe and effective way to boost the specific immune system.

Memory T cells are created when a naive T cell acquires the memory of an antigen. Acquired T cell responses are critical for the host’s defense against microbial pathogens. T cells, by the release of interferon-γ (IFN-γ), induce autophagy, phagosomal maturation, the production of antimicrobial peptides such as cathelicidin, and antimicrobial activity. There is a a mechanism in which vitamin D is required for acquired immunity to overcome the ability of intracellular pathogens to evade macrophage-mediated antimicrobial responses.[3]

While the inflammation generated by innate immune cells [neutrophils, macrophages, monocytes, natural killer (NK) cells, dendritic cells (DCs), etc.] is important in the initial containment of the infection, it also informs and directs the expansion and differentiation of adaptive immune cells. Responding to the inflammatory environment created by the innate response, cells of the adaptive arm of the immune response (B cells, αβ T cells, and γδ T cells) are stimulated to expand in number (proliferate) and to differentiate into cells with a range of functions appropriate for the immunological challenge.[4]

What is necessary for the creation and implementation of interferons?

The role of eating meat in your diet is not yet clearly known; however, animal proteins and amino acids obtained through eating meat likely play an important role in creating interferons. We do know that bacterium found in ruminant cattle (meat and milk) is essential for humans to make Vitamin D. [5] We also know that exposure of the skin to sunlight (UVB radiation) is required for the body to photosynthesize Vitamin D and create the photoproducts. Previtamin D3 and vitamin D3 also absorb UV B radiation and are converted into a variety of photoproducts some of which have unique biologic properties. [6]

“We’ve discovered a new component of the interferon system,” said Michael J. Holtzman, MD, the Selma and Herman Seldin Professor of Medicine. “It does something that other components don’t do, and it works on both sides of the fence: It dials up the body’s internal genes that fight viruses, and it attacks viral proteins directly.”

The researchers’ strategy did not involve increasing the amount of interferon, the first step of this important antiviral signaling cascade. Instead, it dialed up amounts of the protein STAT1, the second component of this cascade, without altering the system’s overall interferon on/off switch.

“Past work to boost this system just kept the interferon signal on all the time,” Holtzman said. “When the system is chronically activated, it is no longer regulated, and that’s where the autoimmune problems may come from. Our system is still regulated by the presence or absence of interferon. Interferon amounts increase when there is an infection and decrease when there is no infection. We’re not boosting interferon itself, but the secondary signal that interferon activates, which sets off the rest of the antiviral cascade. It’s like greasing the wheels. We’re not pushing the system any harder. But when we do push, we get a bigger effect.” [7]

COVID, Vitamin D, Health, and Wellness

Vitamin D, Sunlight, the Season, and People of Color

Your Immune System and Photosynthesized Vitamin D

1. Interferon National Cancer Institute
2. An Immune Protein Could Prevent Severe COVID-19—if It Is Given at the Right Time Scientific American
3. Vitamin D Is Required for IFN-γ–Mediated Antimicrobial Activity of Human Macrophages NIH
4. T cell responses: naïve to memory and everything in between NIH
5. Dr. Karl Kruszelnicki Podcast / Australian Broadcasting Corporation

6. Sunlight and Vitamin D NIH
7. Study reveals new, potent way to boost immunity and fight viruses​​​ Washington University in St.Louis

bookmark_borderOmnivores: About Your Immune System and COVID

By Daniel Brouse

Humans are omnivores. A human’s immune system is dependent on eating an omnivore’s diet. Your immune system is really a collaboration between many of your body’s systems, such as, neurological, respiratory, cardiovascular, and circulatory systems. The “health” of your immune system is dependent on your overall status, but more importantly, the ability of your immune system to respond to any given battle at a particular time.

COVID can cause damage to your organs directly during the fight. COVID can also cause damage to all your body’s systems. Post-COVID chronic ailments comprise both categories. Many COVID cases result in damage to the lungs, heart, kidneys, and brain. Many COVID cases also cause damage to your immune system. (eg Long Haulers Syndrome)

Diet and lifestyle choices are detrimental in both the immune system’s ability to fight individual battles, as well as, your immune system’s ability to survive the war.

THE BATTLE
When an infection starts attacking your body, your immune system starts a process involving most of your body’s systems including neurological, respiratory, cardiovascular, and circulatory systems. Your brain connects with command centers throughout your body. The power supply for these command centers is called NAD+

The timing and locations of the battles are crucial for victory. Your command centers deploy Trojan horses to the nearest fight. The Trojan horses come in a variety of different breeds but are commonly called interferons. The interferons are unique antiviral proteins. They are part of the process that invades the infection, gets inside, steals the memory. Then, the interferon creates more protein. The proteins prevent the virus from multiplying. To help you win the war, the memory of the virus is then transferred to your central intelligence agency and used in your antibody production including T-cells and B-cells.

Your immunity factory needs a bunch of supplies to metabolize in order to win. It is critical that your body make and distribute the supplies to the immune factory assembly line. Supplements may be substituted in an emergency, but supplements can not replace your assembly line. You need to consume plants, animals, O2, H20, and sunlight. Time is of the essence.

WINNING THE BATTLE AGAINST COVID
The simplest strategy to defeat COVID is to consume Niacin (B3) and photosynthesized Vitamin D (sunlight).

Niacin is crucial for the production of your command centers — Nicotinamide adenine dinucleotide (NAD+)

Sunlight is crucial for the production of your interferons. The photosynthesis of Vitamin D produces the Vitamin D you need, but more important for this battle is the timing of the unique photoproducts that are also created in the photosynthesis process — interferons. The interferons need to be deployed rapidly to the exact location of the intruder. In the end, interferons are meat proteins consumed by your immune system. The role of eating meat in your diet is not yet clearly known; however, animal proteins and amino acids obtained through eating meat likely play an important role. We do know that bacterium found in ruminant cattle (meat and milk) is essential for humans to make Vitamin D.

CONCLUSION
To help prevent catching COVID, to help fight COVID, and/or to recover from post-COVID, Niacin and the photosynthesis of Vitamin D are the simplest protocol.

bookmark_borderAir Pollution And Asthma

Air Quality News reports, “Air pollution responsible for half of childhood asthma cases in Barcelona”

Air pollution is responsible for nearly half of all childhood asthma cases in Barcelona, according to research published by the Barcelona Institute of Global Health (ISGlobal).

Asthma is the most common chronic childhood disease, and although it is known to be linked to air pollution, this is the first study to assess the link between asthma and the three pollutants: nitrogen dioxide (NO2), particulate matter (PM2.5) and black carbon (BC).

‘Barcelona urgently needs interventions to reduce the amount of motor-vehicle traffic, which has a negative impact on the health of the city’s children.

‘Reducing traffic does not only reduce air pollution but also reduce noise and heat island effects and increases physical activity which is all beneficial to health.’

bookmark_borderPollution Kills

by Daniel Brouse and Sidd Mukherjee

Pollution will kill you. Usually, it is a slow, painful death.

For the last 20 years, the American Lung Association has analyzed data from official air quality monitors to compile the “State of the Air” report. The most recent report found the United States recorded more days with hazardous air quality than ever. “Hazardous” as air that reaches “emergency conditions” on the government’s air quality index. “More than 4 in 10 people live where pollution levels are too often dangerous to breathe.”

Philadelphia-Reading-Camden, PA-NJ-DE-MD rank as the 21st worst city for ozone and the 18th worst for “Year Round Particle Pollution”. Pittsburgh-New Castle-Weirton, PA-OH-WV ranked 7th worst for year round particle pollution. Lancaster, PA ranked 15th worst for particle pollution.

“Two types of air pollution dominate in the U.S.: ozone and particle pollution1. These two pollutants threaten the health and the lives of millions of Americans. Thanks to the Clean Air Act, the U.S. has far less of both pollutants now than in the past. Still, nearly 141.1 million people live in counties where monitors show unhealthy levels of one or both—meaning the air a family breathes could shorten life or cause lung cancer and other harmful effects. It may be hard to imagine that pollution could be invisible, but ozone is. It is currently one of the least-well-controlled pollutants in the United States. And, it is also one of the most dangerous” the Association reports.

Air Pollution, Health and Wellness
Air Pollution, Health and Wellness

The Institute of Health Metrics and Evaluation at the University of Washington that 5 million deaths per year could be attributed to stroke, heat attack, diabetes, lung cancer and chronic lung disease that resulted from air pollution.

The journal Lancet Planetary Health found air pollution is linked to diabetes.

The National Academy of Sciences published a study that found a significant impact from exposure to air pollution on cognitive performance.

“Today it feels like the future of our kids and our country is at stake,” said former Obama EPA chief Gina McCarthy, now director of the Center for Climate, Health and the Global Environment at the Harvard School of Public Health. “We do not have the cleanest air and we have not crossed the finish line when it comes to pollution.”

Vote for parks. Trees and plants help abate pollution.
If you can, move away from the traffic.
Consider wearing masks.

bookmark_borderEarth Status 2018

Humanity has wiped out 60% of animal populations since 1970 according to a report issued on October 30, 2018 by the World Wildlife Foundation.

Plummeting numbers of mammals, reptiles, amphibians, birds and fish around the world are an urgent sign that nature needs life support. Our Living Planet Report 2018 shows population sizes of wildlife decreased by 60% globally between 1970 and 2014.

For the last 20 years, scientists from ZSL, WWF and other organisations, have been monitoring changes in the populations of thousands of animal species around the world. Sadly, they’ve concluded that the variety of life on Earth and wildlife populations is disappearing fast.

“We are sleepwalking towards the edge of a cliff” said Mike Barrett, executive director of science and conservation at WWF. “If there was a 60% decline in the human population, that would be equivalent to emptying North America, South America, Africa, Europe, China and Oceania. That is the scale of what we have done.”

“This is far more than just being about losing the wonders of nature, desperately sad though that is,” he said. “This is actually now jeopardising the future of people. Nature is not a ‘nice to have’ – it is our life-support system.”

On September 26, 2018, the UN released a report that concluded climate change is happening faster that models predicted, and we reaching the point of no return.

As governments prepare to meet later this year for the next round of climate talks, Secretary-General António Guterres today underscored the need to speed up action on an issue that is “the absolute priority” for the United Nations.

Climate change is the defining issue of our time – and we are at a defining moment,” the Secretary-General said at the Informal Leaders Dialogue on Climate Change, held on the margins of the annual high-level debate of the General Assembly.

“[…] we have many priorities in the UN – peace and security, human rights, and development – but I would say that this is the absolute priority.”

Mr. Guterres recalled that when world leaders signed the Paris Agreement on Climate Change three years ago, they pledged to keep global temperature rise to well below 2 degrees Celsius above pre-industrial levels and to work to keep the increase as close as possible to 1.5 degrees.

These objectives were agreed, he noted, as the “bare minimum” to avoid the worst impacts of climate change.

“The commitment was universal – but we are nowhere close to where we need to be to meet these minimum targets,” he stated, adding that a UN study found that the commitments made so far by Parties to the Paris Agreement represent just one-third of what is needed.

“We need to do more and we need to do it quicker: we need more ambition and accelerated action by 2020.”

On November 23, 2018, a congressionally mandated report on the impacts of climate change. It is believed the White House released it on Black Friday in an attempt to bury it. The report summary:

Climate change creates new risks and exacerbates existing vulnerabilities in communities across the United States, presenting growing challenges to human health and safety, quality of life, and the rate of economic growth.

Impacts from climate change on extreme weather and climate-related events, air quality, and the transmission of disease through insects and pests, food, and water increasingly threaten the health and well-being of the American people, particularly populations that are already vulnerable.

* Climate change will cost the U.S. economy hundreds of billions of dollars by the end of the century, damaging everything from human health to infrastructure and agricultural production, according to a government report.
* The report issued a dire warning at odds with the Trump administration’s pro-fossil fuels agenda.
* The White House dismissed the congressionally mandated reported as inaccurate.

“With continued growth in emissions at historic rates, annual losses in some economic sectors are projected to reach hundreds of billions of dollars by the end of the century – more than the current gross domestic product (GDP) of many U.S. states,” reports the Fourth National Climate Assessment Volume II. “While President Trump continues to ignore the threat of climate change, his own administration is sounding the alarm,” said Abigail Dillen, president of environmental group Earthjustice. “This report underscores what we are already seeing firsthand: climate change is real, it’s happening here, and it’s happening now.”

On November 27, 2018, the UN’s emissions gap report concluded that despite pledges of industrial countries CO2 emissions rose in 2017.

To meet the goals of the Paris climate pact, the study says it’s crucial that global emissions peak by 2020.

But the analysis says that this is now not likely even by 2030.

The Human Induced Climate Change Experiment

bookmark_borderFluoride

By Daniel Brouse

Fluoride occurs naturally in the body as calcium fluoride. Calcium fluoride is essential for the bones and teeth. It is difficult to consume the daily recommended intake of fluoride that naturally occurs in food.

Sources Of Fluoride
The best source of fluoride is through consuming public drinking water. “Almost all water contains some naturally-occurring fluoride, but usually at levels too low to prevent tooth decay. Many communities adjust the fluoride concentration in the water supply to a level known to reduce tooth decay and promote good oral health (often called the optimal level). This practice is known as community water fluoridation, and reaches all people who drink that water. Given the dramatic decline in tooth decay during the past 70 years since community water fluoridation was initiated, the Centers for Disease Control and Prevention (CDC) named fluoridation of drinking water to prevent dental caries (tooth decay) as one of Ten Great Public Health Interventions of the 20th Century.” (CDC)

A 12-ounce glass of fluoridated water contains about 0.248 mg of fluoride or about 6 percent of the daily recommended intake for a man.

A glass of wine contains 7.5 percent of a man’s daily fluoride requirement and 10 percent for a woman.

A large Russet potato baked in the skin contains about 3.5 percent of a man’s daily fluoride requirement 5 percent of woman’s recommended daily intake.

Sea water is high in fluoride making seafood a good source of fluoride.

Daily Recommended Fluoride Intake

Infants and young children

Age AI
0-6 months* –
7-12 months* 0.5 mg/day#
1-3 yr* 0.6 mg/day
4-8 yr* 1.1mg/day

Children & adolescents

Boys
9-13 yr 2.0 mg/day
14-18 yr 3.0 mg/day
Girls
9-13 yr 2.0 mg/day
14-18 yr 3.0 mg/day

Adults:
Men 4 mg/day
Women 3 mg/day

Too Much Fluoride
Some drinking water contains dangerously high levels of fluoride that can lead to serious health problems. “Chronic exposure to fluoride in large amounts interferes with bone formation. In this way, the most widespread examples of fluoride poisoning arise from consumption of ground water that is abnormally fluoride-rich.” (Wikipedia)

Minerals (Elements) and Drinking Water

bookmark_borderAir Pollution: Getting All Choked Up

By Daniel Brouse

Air pollution may be the largest problem facing the world. Emissions of CO2, methane and other greenhouse gases are causing irreversible climate change. Since the effects of global warming take years to become apparent, many people don’t even notice the change; however, air pollution is already the leading cause of death worldwide. Again, since the pollution can’t be seen with the naked eye, many people are in denial of the dire consequences. 92% of the world’s population lives where outdoor air quality fails to meet the World Health Organization (WHO) guidelines.

In March of 2017, Dr. Margaret Chan, director general of the World Health Organization, said air pollution is “one of the most pernicious threats” facing global public health today and is on a much bigger scale than HIV or Ebola. Dr. Chan attributed the deaths of 600,000 children per year to indoor and outdoor air pollution.

UNICEF Executive Director Anthony Lake said, “Pollutants don’t only harm children’s developing lungs, they can actually cross the blood-brain barrier and permanently damage their developing brains, and, thus, their futures. No society can afford to ignore air pollution.”

“Protecting children from air pollution is not only in their best interests; it is also in the best interests of their societies — a benefit realized in reduced health costs, in increased productivity, in a cleaner, safer environment, and thus, in more sustainable development,” Lake said.

It is estimated that 5-7 million people are dying prematurely every year as a result of air pollution.

The American Lung Association says, “Two types of air pollution dominate in the U.S.: ozone and particle pollution. These two pollutants threaten the health and the lives of millions of Americans. Thanks to the Clean Air Act, the U.S. has far less of both pollutants now than in the past. Ozone pollution is the most widespread pollutant in the U.S. and is also one of the most dangerous.”

Ozone Action Alert Days are a frequent occurrence throughout the United States. During an Ozone Alert, you should not breath outside. During any days near metropolitan areas, you should limit outdoor physical activities as deep breathing causes more severe damage. The young and old are at greater risk at all times.

Particle pollution comes from small particles in exhaust and increase the risk of heart disease, lung cancer and asthma attacks. Particulates can interfere with the growth and work of the lungs.

The Environ Health Perspect Study states, “First and foremost, short-term exposure to particle pollution can kill. Peaks or spikes in particle pollution can last for hours to days. Deaths can occur on the very day that particle levels are high, or within one to two months afterward. Particle pollution does not just make people die a few days earlier than they might otherwise—these are deaths that would not have occurred if the air were cleaner.”

In February of 2017, the EPA released an update on air quality in the U.S.:

Today, pollution levels in many areas of the United States exceed national air quality standards for at least one of the six common pollutants:

  • Although levels of particle pollution and ground-level ozone pollution are substantially lower than in the past, levels are unhealthy in numerous areas of the country. Both pollutants are the result of emissions from diverse sources, and travel long distances and across state lines.

    An extensive body of scientific evidence shows that long- and short-term exposures to fine particle pollution, also known as fine particulate matter (PM2.5), can cause premature death and harmful effects on the cardiovascular system, including increased hospital admissions and emergency department visits for heart attacks and strokes. Scientific evidence also links PM to harmful respiratory effects, including asthma attacks.

    Ozone can increase the frequency of asthma attacks, cause shortness of breath, aggravate lung diseases, and cause permanent damage to lungs through long-term exposure. Elevated ozone levels are linked to increases in hospitalizations, emergency room visits and premature death.

    Both pollutants cause environmental damage, and fine particles impair visibility.

    Fine particles can be emitted directly or formed from gaseous emissions including sulfur dioxide or nitrogen oxides. Ozone, a colorless gas, is created when emissions of nitrogen oxides and volatile organic compounds react.

  • For unhealthy peak levels of sulfur dioxide and nitrogen dioxide, EPA is working with states and others on ways to determine where and how often unhealthy peaks occur. Both pollutants cause multiple adverse respiratory effects including increased asthma symptoms, and are associated with increased emergency department visits and hospital admissions for respiratory illness. Both pollutants cause environmental damage, and are byproducts of fossil fuel combustion.
  • Airborne lead pollution, a nationwide health concern before EPA phased out lead in motor vehicle gasoline under Clean Air Act authority, now meets national air quality standards except in areas near certain large lead-emitting industrial facilities. Lead is associated with neurological effects in children, such as behavioral problems, learning deficits and lowered IQ, and high blood pressure and heart disease in adults.
  • The entire nation meets the carbon monoxide air quality standards, largely because of emissions standards for new motor vehicles under the Clean Air Act.

MORE REFERENCES
Health And Air Quality
Air Pollution Deaths
Air Pollution Killing Millions
Largest Health Risk

bookmark_borderGMO’s: Throwing the Baby out with the Bathwater

by Daniel Brouse

The definition of GMO is the modern version, not selective breeding. (0)

GMO’s (genetically modified organism) have been around for thousands of years; however, the irrational fear of GMO’s is a recent phenomenon. Are there risks to GMO’s? Yes. Has there been any evidence of harm to human health? No. The risks associated with GMO’s are from the impact to our ecosystem through the misuse of GMO agricultural practices.

Technically speaking, you are a genetically modified organism.  One of the first patents issued for GMO’s was for medicine. “In 1982, The U.S. Food and Drug Administration approves the first genetically engineered drug, Genentech’s Humulin, a form of human insulin produced by bacteria. This is the first consumer product developed through modern bioengineering.”

The phobia of GMO’s is really a fear of modern bioengineering patents. Modern bioengineering started in 1980. The U.S. Supreme Court ruled that “genetically altered life forms can be patented. The decision allowed the Exxon Oil Company to patent an oil-eating microorganism.” (1)

Another change in the meaning of GMO occurred with the sequencing of genes. “NHGRI led the National Institutes of Health’s contribution to the International Human Genome Project. This project, which had as its primary goal the sequencing of the three thousand million base pairs that make up human genome, was successfully completed in April 2003.” (1.1) With these discoveries all sorts-of risks arose. There are the benefits of being able to use plants similar to the human genome for research. For instance, GMO tobacco plants are being used to help develop new medicines because of their similarity to the human genome. It is the ability of Man to alter genetics so rapidly that is frightening.

SHOULD WE BE AFRAID OF GMO’s?
The use of GMO’s in agriculture practices should be of concern. “There is a case for GMOs and a case against the indiscriminate use of monoculture crops fueled by synthetic fertilizer on dead lands.” (2)

Part of the concern is a monoculture crop. There may be long term impacts from the lack of diversity caused by patent controlled crops. This factor is the least concerning since patents are only good for 17 years. After that, the GMO seed is free to crossbreed.

Of more concern is, “fueled by synthetic fertilizer on dead lands.” The inherent risk from GMO’s is not the plant itself, but how the plant is farmed. Some GMO crops promote the use of RoundUp (glyphosate). RoundUp creates dead lands — the rest of the ecosystem is destroyed, at least to some extent. Certainly, all the other vegetation is extinct from that land. The collapse of bee colonies may, or may not, be part of that destroyed ecosystem. Combining RoundUp with synthetic fertilizer just adds fuel to the deadly mix.  There appears to be no debate that GMO seed created for the purpose of being fed fossil fuel fertilizer has a negative impact on the entire world.

5,000 years ago in China similar agriculture experiments were conducted. (In particular, the cultivation of rice.) Today it is believed these methods of farming are the origins of human induced climate change. (3)

If you look at the impact on Earth as an ecosystem, humans are conducting a deadly agriculture experiment.

PART II: Should we throw the baby out with the bathwater?

On the other hand, GMO farming (in particular, the cultivation of rice) is saving millions of children from dying or going blind. (4)

HUMAN HEALTH
Since 1992, millions of animals have been raised on GMO feed. Since 1996, cows, chickens, pigs and pretty much all other types of livestock have eaten GMO crops. To date, there has not been a single case of a health problem for either the animals nor the humans that consume the meat. This equates to multiple generations being raised without an occurrence of ill health.

Also since 1996, almost all organic produce has been grown using GMO fed manure. During these multiple generations of plants, neither a plant nor human has shown any ill effects related to the GMO dung.

… TO BE CONTINUED.

0) Mark Mullen (2016)
1) American Public Radio (2016)
1.1) Human Genome Project (2003)
2) Sidd (2016)
3) Richard Lovett (2014)
4} Golden Rice / U.S. Patent and Trademark Office (2015)

bookmark_borderKilling Ourselves With Climate Change

WASHINGTON DC — Climate change is maiming and killing humans.

“This isn’t just about glaciers and the polar bears; it’s about the health of our family and our kids,” said Gina McCarthy, administrator of the Environmental Protection Agency, one of eight U.S. agencies that contributed to the report. “To protect ourselves and future generations, we need to understand the health impacts of climate changes that are already happening and those we expect to see down the road.”

The US Global Change Research Program is a report compiled over several years by the federal government. The report states:
Climate change is a significant threat to the health of the American people. The impacts of human-induced climate change are increasing nationwide. Rising greenhouse gas concentrations result in increases in temperature, changes in precipitation, increases in the frequency and intensity of some extreme weather events, and rising sea levels. These climate change impacts endanger our health by affecting our food and water sources, the air we breathe, the weather we experience, and our interactions with the built and natural environments. As the climate continues to change, the risks to human health continue to grow.

Current and future climate impacts expose more people in more places to public health threats. Already in the United States, we have observed climate-related increases in our exposure to elevated temperatures; more frequent, severe, or longer-lasting extreme events; degraded air quality; diseases transmitted through food, water, and disease vectors (such as ticks and mosquitoes); and stresses to our mental health and well-being. Almost all of these threats are expected to worsen with continued climate change. Some of these health threats will occur over longer time periods, or at unprecedented times of the year; some people will be exposed to threats not previously experienced in their locations. Overall, instances of potentially beneficial health impacts of climate change are limited in number and pertain to specific regions or populations. For example, the reduction in cold-related deaths is projected to be smaller than the increase in heat-related deaths in most regions.

Every American is vulnerable to the health impacts associated with climate change. Increased exposure to multiple health threats, together with changes in sensitivity and the ability to adapt to those threats, increases a person’s vulnerability to climate-related health effects. The impacts of climate change on human health interact with underlying health, demographic, and socioeconomic factors. Through the combined influence of these factors, climate change exacerbates some existing health threats and creates new public health challenges. While all Americans are at risk, some populations are disproportionately vulnerable, including those with low income, some communities of color, immigrant groups (including those with limited English proficiency), Indigenous peoples, children and pregnant women, older adults, vulnerable occupational groups, persons with disabilities, and persons with preexisting or chronic medical conditions.

In recent years, scientific understanding of how climate change increases risks to human health has advanced significantly. Even so, the ability to evaluate, monitor, and project health effects varies across climate impacts. For instance, information on health outcomes differ in terms of whether complete, long-term datasets exist that allow quantification of observed changes, and whether existing models can project impacts at the timescales and geographic scales of interest. Differences also exist in the metrics available for observing or projecting different health impacts. For some health impacts, the available metrics only describe changes in risk of exposure, while for others, metrics describe changes in actual health outcomes (such as the number of new cases of a disease or an increase in deaths).

This assessment strengthens and expands our understanding of climate-related health impacts by providing a more definitive description of climate-related health burdens in the United States. It builds on the 2014 National Climate Assessment and reviews and synthesizes key contributions to the published literature. Acknowledging the rising demand for data that can be used to characterize how climate change affects health, this report assesses recent analyses that quantify observed and projected health impacts. Each chapter characterizes the strength of the scientific evidence for a given climate–health exposure pathway or “link” in the causal chain between a climate change impact and its associated health outcome. This assessment’s findings represent an improvement in scientific confidence in the link between climate change and a broad range of threats to public health, while recognizing populations of concern and identifying emerging issues. These considerations provide the context for understanding Americans’ changing health risks and allow us to identify, project, and respond to future climate change health threats. The overall findings underscore the significance of the growing risk climate change poses to human health in the United States.

HUMAN HEALTH
The influences of weather and climate on human health are significant and varied. Exposure to health hazards related to climate change affects different people and different communities to different degrees. While often assessed individually, exposure to multiple climate change threats can occur simultaneously, resulting in compounding or cascading health impacts (see Figure ES2).

With climate change, the frequency, severity, duration, and location of weather and climate phenomena—like rising temperatures, heavy rains and droughts, and some other kinds of severe weather—are changing. This means that areas already experiencing health-threatening weather and climate phenomena, such as severe heat or hurricanes, are likely to experience worsening impacts, such as higher temperatures and increased storm intensity, rainfall rates, and storm surge. It also means that some locations will experience new climate-related health threats. For example, areas previously unaffected by toxic algal blooms or waterborne diseases because of cooler water temperatures may face these hazards in the future as increasing water temperatures allow the organisms that cause these health risks to thrive. Even areas that currently experience these health threats may see a shift in the timing of the seasons that pose the greatest risk to human health.

Climate change can therefore affect human health in two main ways: first, by changing the severity or frequency of health problems that are already affected by climate or weather factors; and second, by creating unprecedented or unanticipated health problems or health threats in places where they have not previously occurred.

Temperature-Related Death and Illness
Increasing concentrations of greenhouse gases lead to an increase of both average and extreme temperatures. This is expected to lead to an increase in deaths and illness from heat and a potential decrease in deaths from cold (see Figure ES3), particularly for a number of communities especially vulnerable to these changes, such as children, the elderly, and economically disadvantaged groups. Days that are hotter than the average seasonal temperature in the summer or colder than the average seasonal temperature in the winter cause increased levels of illness and death by compromising the body’s ability to regulate its temperature or by inducing direct or indirect health complications. Loss of internal temperature control can result in a cascade of illnesses, including heat cramps, heat exhaustion, heatstroke, and hyperthermia in the presence of extreme heat, and hypothermia and frostbite in the presence of extreme cold. Temperature extremes can also worsen chronic conditions such as cardiovascular disease, respiratory disease, cerebrovascular disease, and diabetes-related conditions. Prolonged exposure to high temperatures is associated with increased hospital admissions for cardiovascular, kidney, and respiratory disorders.

Air Quality Impacts
Changes in the climate affect the air we breathe, both indoors and outdoors. The changing climate has modified weather patterns, which in turn have influenced the levels and location of outdoor air pollutants such as ground-level ozone (O3) (see Figure ES4) and fine particulate matter. Increasing carbon dioxide (CO2) levels also promote the growth of plants that release airborne allergens (aeroallergens). Finally, these changes to outdoor air quality and aeroallergens also affect indoor air quality as both pollutants and aeroallergens infiltrate homes, schools, and other buildings. Poor air quality, whether outdoors or indoors, can negatively affect the human respiratory and cardiovascular systems. Higher pollen concentrations and longer pollen seasons can increase allergic sensitization and asthma episodes and thereby limit productivity at work and school.

Extreme Events
Climate change projections show that there will be continuing increases in the occurrence and severity of some extreme events by the end of the century, while for other extremes the links to climate change are more uncertain. Some regions of the United States have already experienced costly impacts—in terms of both lives lost and economic damages (see Figure ES5)—from observed changes in the frequency, intensity, or duration of certain extreme events. While it is intuitive that extremes can have health impacts such as death or injury during an event (for example, drowning during floods), health impacts can also occur before or after an extreme event, as individuals may be involved in activities that put their health at risk, such as disaster preparation and post-event cleanup. Health risks may also arise long after the event, or in places outside the area where the event took place, as a result of damage to property, destruction of assets, loss of infrastructure and public services, social and economic impacts, environmental degradation, and other factors. Extreme events also pose unique health risks if multiple events occur simultaneously or in succession in a given location. The severity and extent of health effects associated with extreme events depend on the physical impacts of the extreme events themselves as well as the unique human, societal, and environmental circumstances at the time and place where events occur.

Vector-Borne Diseases
Vector-borne diseases are illnesses that are transmitted by vectors, which include mosquitoes, ticks, and fleas. These vectors can carry infective pathogens such as viruses, bacteria, and protozoa, which can be transferred from one host (carrier) to another. The seasonality, distribution, and prevalence of vector-borne diseases are influenced significantly by climate factors, primarily high and low temperature extremes and precipitation patterns. Climate change is likely to have both short- and long-term effects on vector-borne disease transmission and infection patterns, affecting both seasonal risk and broad geographic changes in disease occurrence over decades (see Figure ES6). While climate variability and climate change both alter the transmission of vector-borne diseases, they will likely interact with many other factors, including how pathogens adapt and change, the availability of hosts, changing ecosystems and land use, demographics, human behavior, and adaptive capacity. These complex interactions make it difficult to predict the effects of climate change on vector-borne diseases.

Water-Related Illness
Across most of the United States, climate change is expected to affect fresh and marine water resources in ways that will increase people’s exposure to water-related contaminants that cause illness (see Figure ES7). Water-related illnesses include waterborne diseases caused by pathogens, such as bacteria, viruses, and protozoa. Water-related illnesses are also caused by toxins produced by certain harmful algae and cyanobacteria and by chemicals introduced into the environment by human activities. Exposure occurs through ingestion, inhalation, or direct contact with contaminated drinking or recreational water and through consumption of contaminated fish and shellfish. Factors related to climate change—including temperature, precipitation and related runoff, hurricanes, and storm surge—affect the growth, survival, spread, and virulence or toxicity of agents (causes) of water-related illness. Whether or not illness results from exposure to contaminated water, fish, or shellfish is dependent on a complex set of factors, including human behavior and social determinants of health that may affect a person’s exposure, sensitivity, and adaptive capacity. Water resource, public health, and environmental agencies in the United States provide many public health safeguards to reduce risk of exposure and illness even if water becomes contaminated. These include water quality monitoring, drinking water treatment standards and practices, beach closures, and issuing advisories for boiling drinking water and harvesting shellfish.

Food Safety, Nutrition, and Distribution
A safe and nutritious food supply is a vital component of food security. The impacts of climate change on food production, prices, and trade for the United States and globally have been widely examined, including in the recent report “Climate Change, Global Food Security, and the U.S. Food System.” An overall finding of that report was that “climate change is very likely to affect global, regional, and local food security by disrupting food availability, decreasing access to food, and making utilization more difficult.” This chapter focuses on some of the less reported aspects of food security, specifically the impacts of climate change on food safety, nutrition, and distribution. There are two overarching means by which increasing carbon dioxide (CO2) and climate change alter safety, nutrition, and distribution of food. The first is associated with rising global temperatures and the subsequent changes in weather patterns and extreme climate events. Current and anticipated changes in climate and the physical environment have consequences for contamination, spoilage, and the disruption of food distribution. The second pathway is through the direct CO2 “fertilization” effect on plant photosynthesis. Higher concentrations of CO2 stimulate growth and carbohydrate production in some plants, but can lower the levels of protein and essential minerals in a number of widely consumed crops, including wheat, rice, and potatoes, with potentially negative implications for human nutrition.

Mental Health and Well-Being
The effects of global climate change on mental health and well-being are integral parts of the overall climate-related human health impacts. Mental health consequences of climate change range from minimal stress and distress symptoms to clinical disorders, such as anxiety, depression, post-traumatic stress, and suicidality. Other consequences include effects on the everyday life, perceptions, and experiences of individuals and communities attempting to understand and respond appropriately to climate change and its implications. The mental health and well-being consequences of climate change related impacts rarely occur in isolation, but often interact with other social and environmental stressors. The interactive and cumulative nature of climate change effects on health, mental health, and well-being are critical factors in understanding the overall consequences of climate change on human health.

Populations of Concern
Climate change is already causing, and is expected to continue to cause, a range of health impacts that vary across different population groups in the United States. The vulnerability of any given group is a function of its sensitivity to climate change related health risks, its exposure to those risks, and its capacity for responding to or coping with climate variability and change. Vulnerable groups of people, described here as populations of concern, include those with low income, some communities of color, immigrant groups (including those with limited English proficiency), Indigenous peoples, children and pregnant women, older adults, vulnerable occupational groups, persons with disabilities, and persons with preexisting or chronic medical conditions. Characterizations of vulnerability should consider how populations of concern experience disproportionate, multiple, and complex risks to their health and well-being in response to climate change.

Death By Ozone
Health And Air Quality
Human Induced Climate Change Experiments

bookmark_borderChina: Air Quality *Red Alert*

The air pollution in China has become so bad the government has issued their first ever Red Alert. Schools in Beijing are closing and outdoor construction is to cease. The state-run Xinhua news agency says the red alert is the highest possible, and has not been used in the city before.

The air quality is so bad that it is unhealthy to breath. The very young, old and physically active are the most prone to ill-effects. Breathing the air could result in respiratory disease or even death.

Beijing Air Quality
Beijing Air Quality

More on the health risks of air pollution.

More on global warming and climate change.