bookmark_borderLong COVID Update: 3 Years of Living With It

by Daniel Brouse
March 7, 2023

COVID=19

In February of 2020, I contracted SARS-CoV-2. By May of 2020, I recognized a pattern of recurring symptoms including: difficulty breathing, congestion, cough, stomach aches, diarrhea, loss of taste and smell, temperature deregulation, night sweats, nightmares, vivid dreams, dizziness, brain fog, headaches, muscle aches, earaches, and peripheral neuropathy.

Over the next year, I was able to treat most of these symptoms with nicotinic acid; however, reducing the niacin dosage yielded increased symptoms. It was only after becoming fully vaccinated in 2021 (post-infection vaccination) that I appear to have been cured of most of the above symptoms. Approximately ninety days after my second dose of the COVID vaccine I was able to reduce my niacin dosage with no ill side effects.

The problem with long COVID is many aspects of the condition(s) do not readily present themselves. In my case, COVID appears to have permanently:
1) increased hypertension
2) increased blood sugar
3) increased cholesterol

If you have had COVID, I highly recommend a medical physical and complete blood work. Though only 10% of people “present with symptoms”, it appears COVID will impact 99% of survivors in the long-term.

With vaccination, medication, and diet, I have been able to control all of my known conditions.

I’m coming to the conclusion that there are 2 main things going on: 1) persistent virus 2) epigenetic changes

1) SARS-CoV-2 can live in organs for an indefinite period of time. Even after testing negative for weeks, the virus can be active in the brain, heart, blood, etc.

2) There appear to be dozens of epigenetic modifications.  The changes are not uniform across the population due mainly to preexisting conditions and/or predispositions (eg family history).

In my case, it is likely I had both conditions.  The persistent COVID-19 was causing most of my readily apparent symptoms.  The niacin helped treat the NAD+ deficiency but did not help clear the virus. It was only after I was fully vaccinated that I was able to clear the virus.

On the other hand, the epigenetic changes appear to be of a permanent nature.  My genes are now programmed for increased hypertension, blood sugars, and cholesterol. Unfortunately, it is quite likely I have other undetected epigenetic modifications. I am looking to my family history and being extra diligent on cancer and other health screenings.

The BBC has produced a documentary entitled The long haul of long Covid that talks about COVID induced: cognitive impairment, fatigue, lactic acid, metabolic dysfunction, micro clots, hypertension, blood sugar, diabetes, asthma, allergies, overactive immune system, muscle and joint pain, arthritis, migraines, shortness of breath, and other chronic problems.

Three years after the official declaration of a pandemic, 65 million people – one in 10 who had Covid-19 – still have symptoms. Some are so ill they are yet to return to work.

The Economist’s health editor, Natasha Loder, examines the science behind long Covid and hears about the challenges as researchers try to unravel the cause behind a condition associated with around 200 symptoms.

Natasha gains insights about the disease from Dr Walter Koroshetz, co-director of the long Covid Recover study in the United States, pulmonologist Dr Lancelot Pinto in Mumbai, India, and long Covid expert Dr Waasila Jassat in Johannesburg, South Africa.

She also meets Dr Emma Wall at London’s Francis Crick Institute to hear about the UK’s long Covid drug trial and Dr Maria Teresa Ferretti, from the Women’s Brain Project, discusses why women are twice as likely to get long Covid than men.

Some Known COVID Chronic Conditions

* Persistent SARS-CoV-2 RNA in multiple organs and throughout the brain
* Destruction of Good Gut Bacteria Resulting in a Compromised Immune System
* Epigenetic Modifications (Changes to DNA)
* Change in Cell Fate
* Tryptophan Deficiency
* Dysfunctional Kynurenine Pathway
* Neurological Damage
* New-Onset Alzheimer’s Disease
* Exertional Intolerance, Oxygen Extraction, Reduced Exercise Capacity
* Down Regulating NAD+
* Up Regulating IDO
* Rogue Antibodies
* Insulin Reduction, Diabetes, High Cholesterol, Heart Disease and Stroke
* Increased Risk of Cancer
* Blood Clots
* Hypertension, Vascular Disorders, Myocarditis and Heart Disease
* Multisystem Inflammatory Syndrome in Children (MIS-C)
* Dysregulation of the innate immune system, i.e. “cytokine storm”

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

The Long COVID NAD+ Plus Immune System Diet

COVID: Heart-disease Risk Soars

COVID-19: Increased Risk of Autoimmune Diseases

COVID-19 Compromises Your Immune System (Immunocompromised)

COVID-19: reinfection increases risks of death, hospitalization and damage to multiple organs

COVID-19: Aging Accelerant

Long-COVID: 4 Out of 5 Experiencing Limitations in Daily Activities

Long-COVID: What We Know About Long Haulers Syndrome

bookmark_borderCOVID: Hypertension, Heart-disease Risk Soars

by Daniel Brouse

There have been many documented cases of Sars-Cov-2 causing heart problems including Myocarditis (inflammation of the heart.) Johns Hopkins Medicine says, “Coronavirus infection also affects the inner surfaces of veins and arteries, which can cause blood vessel inflammation, damage to very small vessels and blood clots, all of which can compromise blood flow to the heart or other parts of the body.”

Long term studies have now shown a significant long term risk of heart disease. In the Nature article, Heart-disease risk soars after COVID — even with a mild case, the authors report:

Massive study shows a long-term, substantial rise in risk of cardiovascular disease, including heart attack and stroke, after a SARS-CoV-2 infection.

What’s more, the risk was elevated even for those who were under 65 years of age and lacked risk factors, such as obesity or diabetes.
“It doesn’t matter if you are young or old, it doesn’t matter if you smoked, or you didn’t,” says study co-author Ziyad Al-Aly at Washington University in St. Louis, Missouri, and the chief of research and development for the Veterans Affairs (VA) St. Louis Health Care System. “The risk was there.”

“I am actually surprised by these findings that cardiovascular complications of COVID can last so long,” Hossein Ardehali, a cardiologist at Northwestern University in Chicago, Illinois.

Data from the Smidt Heart Institute at Cedars-Sinai found that deaths from heart attacks rose significantly during pandemic surges. “The dramatic rise in heart attacks during the pandemic has reversed what was a prior decades-long steady improvement in cardiac deaths,” said Yee Hui Yeo, MD, first author of the study. “We are still learning the many ways by which COVID-19 affects the body, regardless of age, gender, ethnicity or race.”

Post-COVID individuals should be on the lookout for heart related issues. Studies have shown an increase risk of hypertension. The study Does COVID-19 Cause Hypertension? concluded, “These findings suggest that COVID-19 increases systolic and diastolic BP and may cause new onset hypertension.”

The Journal Nature published the study Long COVID and hypertension-related disorders. “As a sequel to our previous report in 2020 which reviewed the association of COVID-19 and hypertension, we summarize the possible influences of long COVID on hypertension-related organs, including the cardiovascular system, kidney, and endocrine system, as well as the pathophysiological mechanisms associated with the disorders.” The study concludes, “Evidence suggests that long COVID affects the clinical course of hypertension-related disorders, such as CVD, kidney diseases, and endocrine diseases. Studies thus far also indicate that long COVID has greater impacts on older population and women.”

A niacin supplement (nicotinic acid) is recommended to help reduce the severity of long term complications.

ALSO SEE: COVID: Long COVID Update: Living With It

Insulin Reduction, Diabetes, High Cholesterol, Heart Disease and Stroke
COVID, Long-COVID, and Blood Clots

MORE Scientific Research on COVID-19 / SARS-CoV-2

bookmark_borderEconomic Update: Inflation, Interest Rates, AI, Consumer Spending, Climate Change, and Fiscal Policy

by Daniel Brouse
February 3, 2023

This article is about the economic conditions up to 2023 and a forecast for the foreseeable future. It helps to understand fiscal and monetary polices prior to reading the following.

In 2022 and 2023, the Federal Reserve raised their interest rates charged to other banks 4.75 percent in an effort to fight inflation. In the later part of 2022, inflation appeared to level-off and start to decline; however, it would be a mistake to think the war is won.

In essence, the short term rise in Fed interest rates is a fiscal facade. In the short term, the rise in Fed rates strengthens the dollar reversing the pressure on real market interest rates. The rise in rates causes inflows of foreign currency dampening the effect on the Treasury’s borrowing costs. At the same time, it makes imported consumer goods cheaper. What the Fed has done with rate hikes so far has not touched the root causes of inflation — lack of immigration/young workers, consumer spending and debt, and government spending and debt.

Unfortunately, the first one — immigration/young workers — appears to have caused a new paradigm. Instead of workers/employment/unemployment causing a wage inflation spiral, AI and robotics are replacing human labor at a rapid rate. Whereas before we thought it would be 20-50 years before impacting economic models, it appears to already be happening. We don’t know the impact yet, but likely this will be good for inflation (eg no wage inflation.) However, it will be devastating to workers’ incomes. Though income inequality will likely be justified, it won’t be a good thing since everyone will earn next to nothing. There are still a few years for this to play out, so downward pressure on wage inflation will not be felt in time for our current fiscal fiasco.

The second part — consumer spending and debt — has been increasing throughout the Fed’s rate rises fueled in part by the stronger dollar. As long as there is strong consumer demand, there are inflationary pressures. The GDP has been increasing to historic highs during the Fed rate rises. The greater the consumer debt the more severe the inevitable recession will be (multiplied by how much technology replaces workers.) In addition, climate change disasters and ill health effects are growing exponentially. Consumer spending and mass consumption through the exploitation of natural resources is the greatest long-term risk to world economics (and human life.)

The last part — government spending and debt – is the real part of the worst to come in the short term. The increase in the price of the dollar has kept marketplace interest rates artificially low. Over the last several years, the government has budgeted huge multi-trillion dollar spending packages. Most of this money has yet to be borrowed and spent (see debt limit crisis.). When the money is borrowed, the price of the dollar will get hammered, and consumers will feel a huge jump in inflation of imported goods. Long term marketplace interest rates will come under severe pressure. The Fed will be forced to buy Treasuries and print money. This is also hugely inflationary. Next, when the money is spent, hundreds of millions of dollars will be pumped into the economy causing a shift in the demand curve for many goods and services. Again, this is biggly inflationary. A microcosm of what’s to come can be seen in the stimulus checks. The 3.2k/person stimulus checks caused this first little bump in inflation we are seeing now. This is just a drop in the bucket compared to the trillions of government stimulus yet to come. There are some Republicans trying to squash the borrowing/spending, but I doubt they will be successful. Soo….

In conclusion, it will be near impossible to curb inflation through monetary policy. The greatest risk to short term world economics is US fiscal policy.

UPDATE: November 9, 2023

Attention armchair economists, investors, and homeowners:
the 30-year Treasury auction was “bad” today
… when I say bad, I mean bad for those not investing in Treasuries.

What does it mean? The government went to borrow money today, and people didn’t want to lend them money. The 30-year interest rate spiked higher. This is because the government is borrowing record amounts of money.

A Double Whammy
This has two negative feedback loops.
1) the higher interest rates mean the government has to borrow more money to make the interest payments… resulting in higher budget deficits… resulting in more borrowing… resulting in higher interest rates, etc.
2) the government is borrowing the current trillions of dollars over the next couple years… but they have yet to spend it… spending the trillions will result in inflation… which will result in higher interest rates… causing a larger deficit… requiring more borrowing, etc.

The Greatest Risks to the US Economy

  1. Climate Change
  2. Government Spending / Debt
  3. Lack of Immigration

Human induced climate change is an exponential component of an unordered system (chaos theory).

The Age of Loss and Damage is a new way of thinking about economics by combining economics, climate science, statistics, and physics. Until now, economic models have been unfit to capture the full extent of climate damage. Traditionally, “integrated assessment models” (IAMs) were used to forecast “shock” events. IAMs use “quadratic function” to calculate GDP losses by squaring the temperature change, yet ignore other methods (such as the exponential function) that are better suited for rapid change. “Climate change is fundamentally different to other shocks because once it has hit, it doesn’t go away,” said Thierry Philipponnat, author of a report by Finance Watch, a Brussels-based public interest NGO on financial issues. “And if the fundamental assumption is flawed, all the rest makes little sense — if any.”

Reuters reported, “Critics say this (IAMs) choice is doomed to underplay the likely impact – particularly if the planet hits environmental tipping points in which damage is not only irreversible but happens at an ever-accelerating rate.” Thierry Philipponnat’s report, Finance in a Hot House World, concludes: “Climate risk is growing to disruptive levels throughout the financial system and the guardians of financial stability urgently need to adapt their tools to regain control.” The report calls for economic models that do not mislead, scenario analyses that prepare the market, and a new prudential tool to address the build-up of systemic climate risk.

Traditional economics is based upon the “costs and benefits” to society. Since there are no known long-term benefits of climate change to society, the Age of Loss and Damage economics focuses on the exponential costs of climate change to society.

Loss and damage litigation against oil companies and governments will change world economics.

In the spring of 2023, the USA suspended their national debt ceiling. Included in the debt ceiling suspension is a provision for unlimited emergency federal spending. The result is the government can continue to ignore the causes of climate change and instead give trillion-dollar subsidies to the fossil fuel industry through emergency disaster relief. Yes, another vicious circle — more fossil fuels subsidies result in more climate catastrophes resulting in more fossil fuel subsidies, etc. The end result will be additional trillions in government borrowing while the standard of living declines.

According to NOAA, in 2023 (as of November 8), there have been 25 confirmed weather/climate disaster events with losses exceeding $1 billion each to affect United States. These events included 1 drought event, 2 flooding events, 19 severe storm events, 1 tropical cyclone event, 1 wildfire event, and 1 winter storm event. This is the largest number of climate disasters recorded with a notable increase in extreme precipitation events (violent rain).

Meanwhile, the US politicians also fail to address the declining and aging population. By restricting immigration, the government is forcing the acceleration of AI and robotics technology. Although this is great for “productivity”, neither AI nor robots pay taxes. The US economy is based on population growth. Increased emergency spending and a declining tax base results in insolvency.

ALSO SEE: The Economic Monsters: Inflation and Interest Rates

UPDATE 2024: Economic Facts on Immigration, Budget Deficits and Inflation

Business, Finance, and Economics

bookmark_borderCOVID-19: Increased Risk of Autoimmune Diseases

by Daniel Brouse

Not only is COVID-19 known to cause immune system disorders, post-COVID also increases the risk of autoimmune disease.

There are multiple ways COVID has been shown to weaken the immune system (Immunocompromised) including: Destruction of Good Gut Bacteria Resulting in a Compromised Immune System, Dysfunctional Kynurenine Pathway, Down Regulating NAD+, Up Regulating IDO, Rogue Antibodies, Exacerbates Underlying Conditions, and Post–COVID-19 Associated with Immune Cell Infiltration and Altered Gene Expression.

Autoimmunity does not mean the same thing as immunocompromised.   When you are immunocompromised, your immune system is under-performing.  If you are immunocompromised, you have a weakened immune system with a reduced ability to fight infections and other diseases. Autoimmune diseases are usually associated with an overactive immune system that mistakenly attacks healthy cells.  COVID can cause both immunocompromised conditions and autoimmunity diseases. “COVID-19 itself shares some similarities with systemic autoimmune rheumatic diseases, which could be a challenge for diagnostics.”

The matched cohort study Incident autoimmune diseases in association with a SARS-CoV-2 infection found:
Incident autoimmune diseases in association with a SARS-CoV-2 infection
“We found a 42.63% higher likelihood of acquiring autoimmunity for patients who had suffered from COVID-19.”

Conclusions SARS-CoV-2 infection is associated with an increased risk of developing new-onset autoimmune diseases after the acute phase of infection.

A study published in the journal Lancet Risk of autoimmune diseases in patients with COVID-19 found:

“After matching, the COVID-19 cohort exhibited significantly higher risks of rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, dermatopolymyositis, systemic sclerosis, Sjögren’s syndrome, mixed connective tissue disease, Behçet’s disease, polymyalgia rheumatica, vasculitis, psoriasi, inflammatory bowel disease, celiac disease, type 1 diabetes mellitus and mortality.”

The study, titled “Iron Dysregulation and Inflammatory Stress Erythropoiesis Associated with Long-Term Outcome of COVID-19,” reveals that Long-COVID is linked to elevated levels of C-reactive protein and prolonged elevation of cytokines compared to healthy controls. Iron dysregulation is a common occurrence after infections, as the body swiftly moves iron out of the bloodstream to prevent it from becoming a potential breeding ground for harmful bacteria. The study suggests that defects in iron homeostasis, dysregulated erythropoiesis, and immune dysfunction resulting from COVID-19 may contribute to inefficient oxygen transport, inflammatory imbalances, and persistent symptoms. The information on autoimmune diseases emphasizes that an excessive release of cytokines, which are signaling molecules involved in immune responses, can lead to an exaggerated inflammatory response. This heightened inflammation has the potential to damage tissues and contribute to autoimmune diseases, where the immune system mistakenly attacks healthy cells.

The study: Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19

Also see: COVID-19 Compromises Your Immune System (Immunocompromised)

COVID-19 Index

bookmark_borderCOVID-19 Compromises Your Immune System (Immunocompromised)

By Daniel Brouse

SARS-CoV-2 and the results of COVID-19 cause long-term immune system dysfunction. That is to say COVID results in a compromised immune system.

* SARS-CoV-2 infection weakens immune-cell response
The magnitude and quality of a key immune cell’s response to vaccination with two doses of the Pfizer-BioNTech COVID-19 vaccine were considerably lower in people with prior SARS-CoV-2 infection compared to people without prior infection, a study has found. In addition, the level of this key immune cell that targets the SARS-CoV-2 spike protein was substantially lower in unvaccinated people with COVID-19 than in vaccinated people who had never been infected. Importantly, people who recover from SARS-CoV-2 infection and then get vaccinated are more protected than people who are unvaccinated. These findings suggest that the virus damages an important immune-cell response.

* Destruction of Good Gut Bacteria Resulting in a Compromised Immune System
Gut microbiome composition was significantly altered in patients with COVID-19 compared with non-COVID-19 individuals.

* Dysfunctional Kynurenine Pathway
“Targeted and untargeted metabolomics analyses identified altered tryptophan metabolism into the kynurenine pathway, which regulates inflammation and immunity.”

* Down Regulating NAD+
“NAD regulates the inflammatory response in immune and non-immune cells through Sirtuins. Epigenetic regulation of histones and non-histone proteins is induced by sirtuins and is essential for the development, reprogramming, and differentiation of the immune system and its related pathologies. A deregulation of the NAD+ levels has been associated with metabolic diseases and aging-related diseases, including neurodegeneration, defective immune responses, and cancer.”

* Up Regulating IDO
Indoleamine 2,3-dioxygenase (IDO) is an immune checkpoint molecule in the sense that it is an immunomodulatory enzyme produced by alternatively activated macrophages and other immunoregulatory cells. IDO is known to suppress T and NK cells, generate Tregs and myeloid-derived suppressor cells, and also supports angiogenesis.

* Rogue Antibodies
Autoantibodies are antibodies (immune proteins) that mistakenly attack a person’s own healthy tissues and organs. SARS-CoV-2 infection, is associated with many different clinical features that are commonly found in autoimmune diseases, including arthralgias, myalgias, fatigue, sicca, and rashes.

* Dysregulation of the innate immune system, i.e. “cytokine storm”
It is important to note that the severity of disease in humans is not determined only by virus replication but also by the host immune response to the infection, which may lead to dysregulation of the innate immune system, i.e. “cytokine storm” (Omicron SARS-CoV-2 can infect faster and better)

* Reinfection Greater Risks & Exacerbates Underlying Conditions
The evidence shows that reinfection further increases risks of death, hospitalization and damage to multiple organ systems. COVID exacerbates underlying conditions including pulmonary, cardiovascular, hematological, diabetes, gastrointestinal, kidney, mental heal<th, musculoskeletal and neurological disorders

* Post–COVID-19 Associated with Immune Cell Infiltration and Altered Gene Expression
COVID causes long-term immune dysfunction. “These findings indicate that T cell–mediated inflammation persists in the olfactory epithelium long after SARS-CoV-2 has been eliminated from the tissue, suggesting a mechanism for long-term post–COVID-19 smell loss.”

* Elevated Cytokines and Low Iron
Defects in iron homeostasis, dysregulated erythropoiesis contribute to inefficient oxygen transport, inflammatory imbalances, and persistent symptoms. The information on autoimmune diseases emphasizes that an excessive release of cytokines, which are signaling molecules involved in immune responses, can lead to an exaggerated inflammatory response. This heightened inflammation has the potential to damage tissues and contribute to autoimmune diseases, where the immune system mistakenly attacks healthy cells.

Also see: COVID-19: Increased Risk of Autoimmune Diseases

COVID-19 Index

bookmark_borderCOVID-19: reinfection increases risks of death, hospitalization and damage to multiple organs

The study Acute and postacute sequelae associated with SARS-CoV-2 reinfection was published in the Journal Nature.

* The evidence shows that reinfection further increases risks of death, hospitalization and damage to multiple organ systems
* COVID exacerbates underlying conditions including pulmonary, cardiovascular, hematological, diabetes, gastrointestinal, kidney, mental health, musculoskeletal and neurological disorders

First infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risk of acute and postacute death and sequelae in various organ systems. Compared to no reinfection, reinfection contributed additional risks of death, hospitalization, and sequelae including pulmonary, cardiovascular, hematological, diabetes, gastrointestinal, kidney, mental health, musculoskeletal and neurological disorders. The risks were evident regardless of vaccination status. The risks were most pronounced in the acute phase but persisted in the postacute phase at 6 months. Compared to noninfected controls, cumulative risks and burdens of repeat infection increased according to the number of infections. Limitations included a cohort of mostly white males. The evidence shows that reinfection further increases risks of death, hospitalization and sequelae in multiple organ systems in the acute and postacute phase. Reducing overall burden of death and disease due to SARS-CoV-2 will require strategies for reinfection prevention.

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

bookmark_borderClimate Change: No Credible Pathway to 1.5C Limit

The UN Environment Programme (UNEP) insisted there is “no credible pathway to 1.5C in place.” The report Climate change: No ‘credible pathway’ to 1.5C limit found:

National pledges to reduce harmful emissions offer little hope of avoiding climate disaster, UN climate experts said on Thursday, in an urgent appeal for a radical transformation of the energy sector, before it’s too late.

There’s “no credible pathway to 1.5C in place” today, the UN Environment Programme (UNEP) insisted in a new report, despite legally binding promises made at the 2015 Paris Climate Conference to prevent average temperatures rising by more than 1.5C above pre-industrial levels.

Uncomfortable truth
“This report tells us in cold scientific terms what nature has been telling us all year, through deadly floods, storms and raging fires: we have to stop filling our atmosphere with greenhouse gases, and stop doing it fast,” said Inger Andersen, Executive Director of UNEP.

“We had our chance to make incremental changes, but that time is over. Only a root-and-branch transformation of our economies and societies can save us from accelerating climate disaster.”

Despite Nationally Determined Contributions (NDC) promises made by governments in favour of reducing their carbon footprint, pledges made since the last climate summit in Glasgow in 2021 will lead to cuts of less than one per cent of projected 2030 greenhouse gas emissions, according to UNEP.
Paltry reductions

This is the equivalent of just 0.5 gigatonnes of CO2, UNEP calculated, adding that only a 45 per cent emissions reduction will limit global warming to 1.5C.

As it stands today, latest data indicates that the world is on track for a temperature rise of between 2.4C and 2.6C by the end of this century.

“In the best-case scenario, full implementation of unconditional NDCs and additional net-zero emissions commitments point to only a 1.8C increase, so there is hope. However, this scenario is not currently credible based on the discrepancy between current emissions, short-term NDC targets and long-term net-zero targets,” UNEP said.
Fossil fuel-free solution

For the situation to improve, a “large-scale, rapid” and fossil fuel-free shake-up is needed of our “electricity supply, industry, transport and buildings sectors, and the food and financial systems” to cut emissions by 45 per cent to limit global warming to 1.5C, and by 30 per cent to keep average temperature rise to 2C, the UN agency explained.

And although the transformation towards net-zero greenhouse gas emissions is underway in electricity supply, industry, transportation and buildings, it needs to move “much faster”, the report concludes.

It found that electricity supply transformation had made most progress in some countries, amid dramatically reduced renewable electricity prices.

“It is a tall, and some would say impossible order, to reform the global economy and almost halve greenhouse gas emissions by 2030, but we must try,” said Ms. Andersen. “Every fraction of a degree matters: to vulnerable communities, to species and ecosystems, and to every one of us.”
Food system reform

Rapid and lasting emissions cuts are needed in food production industries too, as this accounts for about a third of greenhouse gases, UNEP continued.

It noted that action in four areas – protection of natural ecosystems, dietary changes, improvements in farm food production and decarbonization of food supply chains – would reduce food system emissions by 2050 to around a third of current levels.

Global Warming

bookmark_borderHealth and Climate Change: Health at the Mercy of Fossil Fuels

The Lancet released the report The 2022 report of the Lancet Countdown on health and climate change: health at the mercy of fossil fuels.

Q: Are millions of people already dying as a result of human induced climate change?
A: Yes.

Q: Can millions of people’s lives still be saved?
A: Yes, “a health-centred response can still deliver a thriving future if immediate action is taken.”
“The health impacts of multiple crises are being exacerbated by persistent fossil fuel dependence and putting additional strain on health systems. This is resulting in increased risk of food insecurity, infectious disease transmission, heat-related disease, energy poverty, and deaths from exposure to air pollution.”

A call to action
After 30 years of UNFCCC negotiations, the Lancet Countdown indicators show that countries and companies continue to make choices that threaten the health and survival of people in every part of the world. As countries devise ways to recover from the coexisting crises, the evidence is unequivocal. At this critical juncture, an immediate, health-centred response can still secure a future in which world populations can not only survive, but thrive.

Key findings of the 2022 report of the Lancet Countdown

  • • Climate change is undermining every dimension of global health monitored, increasing the fragility of the global systems that health depends on, and increasing the vulnerability of populations to the coexisting geopolitical, energy, and cost-of-living crises.
  • • Climate change is increasingly undermining global food security, exacerbating the effects of the COVID-19, geopolitical, energy, and cost-of-living crises. New analysis of 103 countries shows that days of extreme heat, increasing in frequency and intensity due to climate change, accounted for an estimated 98 million more people reporting moderate to severe food insecurity in 2020 than the average in 1981–2010 (indicator 1.4).
  • • Well-prepared health systems are essential to protect populations from the health impacts of climate change. However, global health systems have been drastically weakened by the effects of the COVID-19 pandemic, and the funds available for climate action decreased in 239 (30%) of 798 cities (indicator 2.1.3), with health systems increasingly being affected by extreme weather events and supply chain disruptions too.
  • • Insufficient climate change adaptation efforts have left health systems vulnerable to climate change-related health hazards. Only 48 of 95 countries have assessed their climate change adaptation needs (indicator 2.1.1) and only 63% of countries reported high to very high implementation status for health emergency management in 2021 (indicator 2.2.4). Increasing adaptation to climate change has the potential to simultaneously improve the capacity of health systems to manage both future infectious disease outbreaks and other health emergencies (indicator 2.3.1).
  • • Mitigation of the energy sector is crucial to keep the rise in global mean surface temperatures within the 1·5°C target set in the Paris Agreement. However, the energy sector is still heavily reliant on fossil fuels. Its carbon intensity decreased by less than 1% since the year the UNFCCC was signed, and a simultaneous increase in energy demand of 59% has increased total energy sector emissions to record high levels in 2021 (indicator 3.1). Now, as countries seek alternatives to Russian fossil fuels, many are backsliding to coal, and shifts in global energy supplies risk a net increase in fossil fuel production and consumption.
  • • The slow adoption of renewable energies, which contribute to only 2.2% of total global energy supply (indicator 3.1), means households remain vulnerable to highly volatile international fossil fuel markets, and millions lack access to reliable, clean sources of fuel. Traditional biomass accounts for 31% of the energy consumed in the domestic sector globally, and for 96% of that in low HDI countries (indicator 3.2). New analysis shows that the air in people’s homes in 62 countries analysed exceeded WHO guidelines for safe concentrations of small particulate air pollution (PM2·5) in 2020, by 30-fold on average (indicator 3.2). The current energy and cost-of-living crises, now threatens to worsen enery poverty.
  • • A new indicator this year reveals that, on the basis of their existing production strategies and market shares, 15 of the largest oil and gas companies would exceed their share of greenhouse gas emissions compatible with the 1·5°C climate target by an average of 87% (publicly-listed international companies) and 111% (state-owned national companies) in 2040 making the goals of the Paris Agreement unattainable (indicator 4.2.6).
  • • In 2019, 69 (80%) of 86 countries reviewed had net-negative carbon prices (ie, provided a net subsidy to fossil fuels) for a net total of US$400 billion. These subsidies exceeded 10% of national health spending in 31 countries and exceeded 100% in 5 countries (indicator 4.2.4). Meanwhile, climate efforts are being undercut by a profound scarcity of funding (indicator 2.1.1).
  • • A health-centred response to the coexisting climate, energy, and cost-of-living crises provides an opportunity to deliver a healthy, low-carbon future. Transitioning to clean energy and improved energy efficiency can avert the most catastrophic climate change impacts, while also improving energy security, supporting economic recovery, preventing the 1·2 million annual deaths resulting from exposure to fossil fuel-derived ambient PM2·5 (indicator 3.3), and improving health outcomes by promoting active forms of travel for greener cities. The associated reduction in the burden of disease will in turn reduce the strain on overwhelmed healthcare providers, and enable better care.
  • • The media, the scientific community, corporations, and country leaders are increasingly engaging in health and climate change (indicators 5.1–5.5), and new analysis shows that 86% of updated or new Nationally Determined Contributions now reference health (indicator 5.4).
  • • Countries are attempting to cut their dependence on international oil and gas supplies in response to the war in Ukraine and energy crisis, with some focusing on increasing renewable energy generation, raising hopes that a health-centred response could be emerging. However, the increased engagement and commitments must be urgently translated into action for hope to turn into reality.

Executive summary

The 2022 report of the Lancet Countdown is published as the world confronts profound and concurrent systemic shocks. Countries and health systems continue to contend with the health, social, and economic impacts of the COVID-19 pandemic, while Russia’s invasion of Ukraine and a persistent fossil fuel overdependence has pushed the world into global energy and cost-of-living crises. As these crises unfold, climate change escalates unabated. Its worsening impacts are increasingly affecting the foundations of human health and wellbeing, exacerbating the vulnerability of the world’s populations to concurrent health threats.

During 2021 and 2022, extreme weather events caused devastation across every continent, adding further pressure to health services already grappling with the impacts of the COVID-19 pandemic. Floods in Australia, Brazil, China, western Europe, Malaysia, Pakistan, South Africa, and South Sudan caused thousands of deaths, displaced hundreds of thousands of people, and caused billions of dollars in economic losses. Wildfires caused devastation in Canada, the USA, Greece, Algeria, Italy, Spain, and Türkiye, and record temperatures were recorded in many countries, including Australia, Canada, India, Italy, Oman, Türkiye, Pakistan, and the UK. With advancements in the science of detection and attribution studies, the influence of climate change over many events has now been quantified.

Because of the rapidly increasing temperatures, vulnerable populations (adults older than 65 years, and children younger than one year of age) were exposed to 3·7 billion more heatwave days in 2021 than annually in 1986–2005 (indicator 1.1.2), and heat-related deaths increased by 68% between 2000–04 and 2017–21 (indicator 1.1.5), a death toll that was significantly exacerbated by the confluence of the COVID-19 pandemic.

Simultaneously, the changing climate is affecting the spread of infectious diseases, putting populations at higher risk of emerging diseases and co-epidemics. Coastal waters are becoming more suitable for the transmission of Vibrio pathogens; the number of months suitable for malaria transmission increased by 31·3% in the highland areas of the Americas and 13·8% in the highland areas of Africa from 1951–60 to 2012–21, and the likelihood of dengue transmission rose by 12% in the same period (indicator 1.3.1). The coexistence of dengue outbreaks with the COVID-19 pandemic led to aggravated pressure on health systems, misdiagnosis, and difficulties in management of both diseases in many regions of South America, Asia, and Africa.

The economic losses associated with climate change impacts are also increasing pressure on families and economies already challenged with the synergistic effects of the COVID-19 pandemic and the international cost-of-living and energy crises, further undermining the socioeconomic determinants that good health depends on. Heat exposure led to 470 billion potential labour hours lost globally in 2021 (indicator 1.1.4), with potential income losses equivalent to 0·72% of the global economic output, increasing to 5·6% of the GDP in low Human Development Index (HDI) countries, where workers are most vulnerable to the effects of financial fluctuations (indicator 4.1.3). Meanwhile, extreme weather events caused damage worth US$253 billion in 2021, particularly burdening people in low HDI countries in which almost none of the losses were insured (indicator 4.1.1).

Through multiple and interconnected pathways, every dimension of food security is being affected by climate change, aggravating the impacts of other coexisting crises. The higher temperatures threaten crop yields directly, with the growth seasons of maize on average 9 days shorter in 2020, and the growth seasons of winter wheat and spring wheat 6 days shorter than for 1981–2010 globally (indicator 1.4). The threat to crop yields adds to the rising impact of extreme weather on supply chains, socioeconomic pressures, and the risk of infectious disease transmission, undermining food availability, access, stability, and utilisation. New analysis suggests that extreme heat was associated with 98 million more people reporting moderate to severe food insecurity in 2020 than annually in 1981–2010, in 103 countries analysed (indicator 1.4). The increasingly extreme weather worsens the stability of global food systems, acting in synergy with other concurrent crises to reverse progress towards hunger eradication. Indeed, the prevalence of undernourishment increased during the COVID-19 pandemic, and up to 161 million more people faced hunger during the COVID-19 pandemic in 2020 than in 2019. This situation is now worsened by Russia’s invasion of Ukraine and the energy and cost-of-living crises, with impacts on international agricultural production and supply chains threatening to result in 13 million additional people facing undernutrition in 2022.

A debilitated first line of defence

With the worsening health impacts of climate change compounding other coexisting crises, populations worldwide increasingly rely on health systems as their first line of defence. However, just as the need for healthcare rises, health systems worldwide are debilitated by the effects of the COVID-19 pandemic and the energy and cost-of-living crises. Urgent action is therefore needed to strengthen health-system resilience and to prevent a rapidly escalating loss of lives and to prevent suffering in a changing climate. However, only 48 (51%) of 95 countries reported having assessed their climate change adaptation needs (indicator 2.1.1) and, even after the profound impacts of COVID-19, only 60 (63%) countries reported a high to very high implementation status for health emergency management in 2021 (indicator 2.2.4).

The scarcity of proactive adaptation is shown in the response to extreme heat. Despite the local cooling and overall health benefits of urban greenspaces, only 277 (27%) of 1038 global urban centres were at least moderately green in 2021 (indicator 2.2.3), and the number of households with air conditioning increased by 66% from 2000 to 2020, a maladaptive response that worsens the energy crisis and further increases urban heat, air pollution, and greenhouse gas emissions.

As converging crises further threaten the world’s life-supporting systems, rapid, decisive, and coherent intersectoral action is essential to protect human health from the hazards of the rapidly changing climate.

Health at the mercy of fossil fuels

The year 2022 marks the 30th anniversary of the signing of the UN Framework Convention on Climate Change, in which countries agreed to prevent dangerous anthropogenic climate change and its deleterious effects on human health and welfare. However, little meaningful action has since followed. The carbon intensity of the global energy system has decreased by less than 1% since the UNFCCC was established, and global electricity generation is still dominated by fossil fuels, with renewable energy contributing to only 8·2% of the global total (indicator 3.1). Simultaneously, the total energy demand has risen by 59%, increasing energy-related emissions to a historical high in 2021. Current policies put the world on track to a catastrophic 2·7°C increase by the end of the century. Even with the commitments that countries set in the Nationally Determined Contributions (NDCs) updated up until November 2021, global emissions could be 13·7% above 2010 levels by 2030—far from the 43% decrease from current levels required to meet Paris Agreement goals and keep temperatures within the limits of adaptation.

Fossil fuel dependence is not only undermining global health through increased climate change impacts, but also affects human health and wellbeing directly, through volatile and unpredictable fossil fuel markets, frail supply chains, and geopolitical conflicts. As a result, millions of people do not have access to the energy needed to keep their homes at healthy temperatures, preserve food and medication, and meet the seventh Sustainable Development Goal (to ensure access to affordable, reliable, sustainable, and modern energy for all). Without sufficient support, access to clean energy has been particularly slow in low HDI countries, and only 1·4% of their electricity came from modern renewables (mostly wind and solar power) in 2020 (indicator 3.1). An estimated 59% of health-care facilities in low and middle-income countries still do not have access to the reliable electricity needed to provide basic care. Meanwhile, biomass accounts for as much as 31% of the energy consumed in the domestic sector globally, mostly from traditional sources—a proportion that increases to 96% in low HDI countries (indicator 3.2). The associated burden of disease is substantial, with the air in people’s homes exceeding WHO guidelines for safe concentrations of small particulate air pollution (PM2·5) in 2020 by 30-fold on average in the 62 countries assessed (indicator 3.2). After 6 years of improvement, the number of people without access to electricity increased in 2020 as a result of the socioeconomic pressures of the COVID-19 pandemic. The current energy and cost-of-living crises now threaten to reverse progress toward affordable, reliable, and sustainable energy, further undermining the socioeconomic determinants of health.

Simultaneously, oil and gas companies are registering record profits, while their production strategies continue to undermine people’s lives and wellbeing. An analysis of the production strategies of 15 of the world’s largest oil and gas companies, as of February 2022, revealed they exceed their share of emissions consistent with 1·5°C of global heating (indicator 4.2.6) by 37% in 2030 and 103% in 2040, continuing to undermine efforts to deliver a low carbon, healthy, liveable future. Aggravating this situation even further, governments continue to incentivise fossil fuel production and consumption: 69 (80%) of 86 countries reviewed had net-negative carbon prices (ie, provided a net subsidy to fossil fuels) for a net total of US$400 billion in 2019, allocating amounts often comparable with or even exceeding their total health budgets (indicator 4.2.4). Simultaneously, wealthier countries failed to meet their commitment of mobilising the considerably lower sum of $100 billion annually by 2020 as agreed at the 2009 Copenhagen Accord to support climate action in “developing countries”, and climate efforts are being undercut by a profound scarcity of funding (indicator 2.1.1). The impacts of climate change on global economies, together with the recession triggered by COVID-19 and worsened by geopolitical instability, could paradoxically further reduce the willingness of countries to allocate the funds needed to enable a just climate transition.

A health-centred response for a thriving future

The world is at a critical juncture. With countries facing concurrent crises, the implementation of long-term emissions-reduction policies risks being deflected or defeated by challenges wrongly perceived as more immediate. Addressing each of the concurrent crises in isolation risks alleviating one, while worsening another. Such a situation is emerging from the response to COVID-19, which has so far has not delivered the green recovery that the health community proposed, and, on the contrary, is aggravating climate change-related health risks. Less than one third of $3·11 trillion allocated to COVID-19 economic recovery is likely to reduce greenhouse gas emissions or air pollution, with the net effect likely to increase emissions. The COVID-19 pandemic affected climate action at the city level, and 239 (30%) of 798 cities reported that COVID-19 reduced financing available for climate action (indicator 2.1.3).

As countries search for alternatives to Russian oil and gas, many continue to favour the burning of fossil fuels, with some even turning back to coal. Shifts in global energy supplies threaten to increase fossil fuel production. Even if implemented as a temporary transition, these responses could reverse progress on air quality improvement, irreversibly push the world off track from meeting the commitments set out in the Paris Agreement, and guarantee a future of accelerated climate change that threatens human survival.

On the contrary, in this pivotal moment, a health-centred response to the current crises would still provide the opportunity for a low-carbon, resilient future, which not only avoids the health harms of accelerated climate change, but also delivers improved health and wellbeing through the associated co-benefits of climate action. Such response would see countries promptly shifting away from fossil fuels, reducing their dependence on fragile international oil and gas markets, and accelerating a just transition to clean energy sources. A health-centred response would reduce the likelihood of the most catastrophic climate change impacts, while improving energy security, creating an opportunity for economic recovery, and offering immediate health benefits. Improvements in air quality would help to prevent the 1·2 million deaths resulting from exposure to fossil fuel-derived ambient PM2·5 in 2020 alone (indicator 3.3), and a health-centred energy transition would enhance low-carbon travel and increase urban green spaces, promoting physical activity, and improving physical and mental health. In the food sector, an accelerated transition to balanced and more plant-based diets would not only help reduce the 55% of agricultural sector emissions coming from red meat and milk production (indicator 3.5.1), but also prevent up to 11·5 million diet-related deaths annually (indicator 3.5.2), and substantially reduce the risk of zoonotic diseases. These health-focused shifts would reduce the burden of communicable and non-communicable diseases, reducing the strain on overwhelmed health-care providers. Importantly, accelerating climate change adaptation would lead to more robust health systems, minimising the negative impacts of future infectious disease outbreaks and geopolitical conflicts, and restoring the first line of defence of global populations.

Emerging glimmers of hope

Despite decades of insufficient action, emerging, albeit few, signs of change provide some hope that a health-centred response might be starting to emerge. Individual engagement with the health dimensions of climate change, essential to drive and enable an accelerated response, increased from 2020 to 2021 (indicator 5.2), and coverage of health and climate change in the media reached a new record high in 2021, with a 27% increase from 2020 (indicator 5.1). This engagement is also reflected by country leaders, with a record 60% of 194 countries focusing their attention on the links between climate change and health in the 2021 UN General Debate, and with 86% of national updated or new NDCs making references to health (indicator 5.4). At the city level, local authorities are progressively identifying risks of climate change on the health of their populations (indicator 2.1.3), a first step to delivering a tailored response that strengthens local health systems. Although the health sector is responsible for 5·2% of all global emissions (indicator 3.6), it has shown impressive climate leadership, and 60 countries had committed to transitioning to climate-resilient and/or low-carbon or net-zero carbon health systems as part of the COP26 Health Programme, as of July, 2022.

Signs of change are also emerging in the energy sector. Although total clean energy generation remains grossly insufficient, record high levels were reached in 2020 (indicator 3.1). Zero-carbon sources accounted for 80% of investment in electricity generation in 2021 (indicator 4.2.1), and renewable energies have reached cost parity with fossil fuel energies. As some of the highest emitting countries attempt to cut their dependence on oil and gas in response to the war in Ukraine and soaring energy prices, many are focusing on increasing renewable energy generation, raising hopes for a health-centred response. However, increased awareness and commitments should be urgently translated into action for hope to turn into reality.

A call to action

After 30 years of UNFCCC negotiations, the Lancet Countdown indicators show that countries and companies continue to make choices that threaten the health and survival of people in every part of the world. As countries devise ways to recover from the coexisting crises, the evidence is unequivocal. At this critical juncture, an immediate, health-centred response can still secure a future in which world populations can not only survive, but thrive.

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bookmark_borderCOVID-19: Aging Accelerant

In three separate studies of the kidneys, heart, and brain, COVID-19 has been found to act as an aging accelerant.

“Some of the theories for what may be causing long-COVID symptoms include the persistence of the virus. So, instead of the virus coming and going, it sticks around causing inflammation, auto-immune problems and changes in the microbiome,” Dr. Michael Peluso, an infectious disease specialist at the University of California, San Francisco said.

“You can start thinking about getting COVID as almost an accelerant to aging. The viral infection accelerates the aging process in people,” said Dr. Ziyad Al-Aly, director of the Clinical Epidemiology Center at Washington University in St. Louis and the chief of research and education service at Veterans Affairs St. Louis Health Care System.

Dr. Al-Aly researched data from millions of people across the country. The studies on kidney outcomes in long COVID, long COVID in the brain and long COVID in the heart had similar patterns.

“We have seen that people are losing about three to four percent kidney function in the year following that infection. That usually happens with three to four years of aging,” Al-Aly said.

Long-term cardiovascular outcomes of COVID-19

Long-term neurologic outcomes of COVID-19

Kidney Outcomes in Long COVID

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bookmark_borderClimate Change: Viruses and Bacteria Reawaken

The proceeding of the Royal Proceedings released the report Viral spillover risk increases with climate change in High Arctic lake sediments.

Scientists in Canada wanted to investigate how climate change might affect spillover risk by examining samples from the Arctic landscape of Lake Hazen.

It is the largest lake in the world entirely north of the Arctic Circle, and “was truly unlike any other place I’ve been”, said researcher Graham Colby.

“It could be anything from ticks to mosquitoes to certain animals, to bacteria and viruses themselves,” said Lemieux.

“It’s really unpredictable… and the effect of spillover itself is very unpredictable, it can range from benign to an actual pandemic.”

The host spectrum of viruses is quite diverse, as they can sustainedly infect a few species to several phyla. When confronted with a new host, a virus may even infect it and transmit sustainably in this new host, a process called ‘viral spillover’. However, the risk of such events is difficult to quantify. As climate change is rapidly transforming environments, it is becoming critical to quantify the potential for spillovers. To address this issue, we resorted to a metagenomics approach and focused on two environments, soil and lake sediments from Lake Hazen, the largest High Arctic freshwater lake in the world. We used DNA and RNA sequencing to reconstruct the lake’s virosphere in both its sediments and soils, as well as its range of eukaryotic hosts. We then estimated the spillover risk by measuring the congruence between the viral and the eukaryotic host phylogenetic trees, and show that spillover risk increases with runoff from glacier melt, a proxy for climate change. Should climate change also shift species range of potential viral vectors and reservoirs northwards, the High Arctic could become fertile ground for emerging pandemics.

More articles on Climate Change and Health and Global Warming.