bookmark_borderIntroduction to COVID-19: Understanding the Long-Term Impact

Author: Daniel Brouse

COVID Science Updates

COVID-19, caused by the SARS-CoV-2 virus, has left an indelible mark on global health, demonstrating not only its immediate threat but also the potential for enduring consequences. This article explores the profound and lasting impact of COVID-19, delving into the virus’s role in chronic conditions and its ability to leave a lasting imprint on various aspects of health.

Long-Term Complications and Excess Deaths

A COVID-19 infection often leads to persistent complications that significantly diminish both the quality of life and life expectancy. Shockingly, 10% of excess deaths can be directly attributed to COVID itself, while the remaining 90% are attributed to what can be considered COVID’s silent killers. Individuals who have experienced COVID may face a diminished quality of life and an increased risk of premature death. Dr. Rob Wust underscores this by stating, “There is something inside the body going wrong with the disease.”

Long-COVID: A Looming Reality

For those who have contracted COVID, the probability of developing chronic conditions, known as Long-COVID, is a staggering 99%. This alarming statistic underscores the pervasive and lasting impact of the virus on an individual’s health.

Key Insights into COVID-19’s Long-Term Effects

  1. Direct Impact on Organs:
    • COVID-19 has been responsible for millions of deaths and has caused long-term damage to vital organs, leaving many survivors permanently disabled.
  2. Persistent Viral Presence:
    • SARS-CoV-2 can persist in the body for months or even years, causing chronic infections and leaving behind viral proteins associated with Long-COVID. This persistence is comparable to other viruses like Chicken Pox leading to Shingles or Epstein-Barr virus contributing to Mononucleosis and Multiple Sclerosis.
  3. Compromised Immune System and Autoimmune Risks:
    • Post-COVID individuals often experience a compromised immune system and an increased risk of autoimmune diseases. Local immune responses may be disturbed by both mental and physical exertion in long-COVID patients.
  4. Genetic and Epigenetic Changes:
    • SARS-CoV-2 induces genetic and epigenetic alterations to DNA, resulting in a compromised immune system, elevated risks of diabetes, hypertension, cancer, and damage to neurological, circulatory, and cardiovascular systems. Predisposed conditions are likely to escalate to more advanced stages.
  5. Complexity of Long-COVID:
    • Long-COVID is likely a multifaceted condition involving persistent virus presence, residual viral proteins, and lasting epigenetic and genetic changes, potentially lasting indefinitely.
  6. Increased Risks with Reinfection:
    • Reinfection with COVID amplifies the risks of death, hospitalization, and multi-organ damage, exacerbating underlying conditions across various bodily systems.

Understanding the epigenetic changes induced by COVID, including the downregulation of NAD+ and the impact on tryptophan, sheds light on the physical and mental health challenges faced by individuals. The deficiency in niacin, zinc, and vitamin D is a common consequence. It is crucial to recognize that COVID’s epigenetic changes may vary widely based on an individual’s genetic makeup, requiring tailored treatments for optimal outcomes.

COVID-19 / SARS-CoV-2 / Novel Coronavirus

bookmark_borderCOVID: Excess Deaths and Quality of Life

by Daniel Brouse
December 14, 2023

COVID=19

Long-COVID, or post-infection COVID, appears to affect the majority of the population. For individuals that “recover” from COVID-19, they can expect a decreased quality of life and a premature death.

Decrease in Quality of Life
Known chronic conditions resulting from a COVID infection include: Permanent Organ Damage, Persistent SARS-CoV-2 RNA in multiple organs and throughout the brain, Destruction of Good Gut Bacteria Resulting in a Compromised Immune System, Epigenetic Modifications (Changes to DNA), Change in Cell Fate, Tryptophan Deficiency, Dysfunctional Kynurenine Pathway, Neurological Damage, New-Onset Alzheimer’s Disease, Exertional Intolerance, Oxygen Extraction, Reduced Exercise Capacity, Down Regulating NAD+, Up Regulating IDO, Rogue Antibodies, Insulin Reduction, Diabetes, High Cholesterol, Heart Disease and Stroke, Increased Risk of Cancer, Blood Clots, Hypertension, Vascular Disorders, Myocarditis and Heart Disease, Multisystem Inflammatory Syndrome in Children (MIS-C), and Dysregulation of the innate immune system, i.e. “cytokine storm”.

Decrease in Life Expectancy
In epidemiology, the excess deaths or excess mortality is a measure of the increase in the number deaths.

On October 26, 2023, Insurance News Network reported, “Excess mortality is the difference between the total number of deaths for a specific time period and the number that would have been expected. The numbers were naturally forecast to climb during the pandemic, but some industry and health authorities are concerned the rates haven’t greatly diminished as COVID infection rates have declined.”

In November of 2023, the SOA Research Group released Group Life COVID-19 Mortality Survey Report finding the 39-month period of April 2020 through June 2023 showed the following Group Life mortality results:
• Estimated reported Group Life claim incidence rates were up 13.2% on a seasonally-adjusted basis compared to 2017–2019 reported claims.
• Estimated incurred Group Life incidence rates were 12.2% higher than baseline on a seasonally-adjusted basis. As noted above, the incurred incidence rates in May and June 2023 are based on fairly incomplete data, so they are subject to change and should not be fully relied upon at this point.

90% of these excess deaths were caused by post-COVID conditions. 10% of the excess deaths are attributed to the COVID virus.

A Boston University study identified a total of 1,179,024 excess deaths from March 2020 through February 2022, including an estimated 634,830 excess deaths from March 2020 to February 2021, and 544,194 estimated excess deaths from March 2021 to February 2022.

Causes
A decrease in life expectancy, quality of life, or death after a COVID infection is usually caused by complications from the infection, persistent virus (chronic infection), and/or epigenetic changes.

COVID-19 / SARS-CoV-2 / Novel Coronavirus

bookmark_borderLong-COVID 2023 / 2024 Update

COVID=19

by Daniel Brouse
November 2023 – March 2024

In February of 2020, I contracted SARS-CoV-2. Then, I continued to experience long-term complications and chronic conditions. The article Long COVID Update: 3 Years of Living With It describes the symptoms and the knowledge gained from the experience.

Now I am approaching 4 years and continue to get asked for help by others. Here is what I have learned:

Long-COVID has pretty much been classified into three categories — complications from the infection, persistent virus (chronic infection), and epigenetic changes. Complications from infection are lifelong chronic conditions most often seen in the lungs and respiratory system. Persistent virus can sometimes be cured with post-infection vaccination. Epigenetic changes can sometimes be reversed but many times they cannot. It is likely some epigenetic changes can become genetic changes that may be passed on to future generations (similar to cigarette smoking.)

The most significant research has found that defects in iron homeostasis (low iron), dysregulated erythropoiesis, and immune dysfunction (prolonged elevation of cytokines) resulting from COVID-19 may contribute to inefficient oxygen transport, inflammatory imbalances, and persistent symptoms. The information on autoimmune diseases emphasizes that an excessive release of cytokines, which are signaling molecules involved in immune responses, can lead to an exaggerated inflammatory response. This heightened inflammation has the potential to damage tissues and contribute to autoimmune diseases, where the immune system mistakenly attacks healthy cells.

Overview
1) The virus itself can cause death and long term organ damage. Millions and millions of people have died from COVID. Many millions more have become permanently disabled.
2) SARS-CoV-2 can be a persistent virus (chronic infection) that continues to live and destroy your organs for months or years after the initial infection. COVID may also leave residual SARS-CoV-2 protein that is associated with long COVID. A persistent virus behaves in various ways. With Chicken Pox, it leads to Shingles. With Epstein-Barr virus (EBV), it leads to Mononucleosis and Multiple Sclerosis. Epstein-Barr is a member of the herpesvirus family. Many people are already familiar with the persistent nature of herpes viruses, such as, cold sores and genital herpes. HIV is another example of a persistent virus. COVID acts like an accelerant to aging and has been found to impact the function of multiple organs including the kidneys, heart, and brain.
3) Post-COVID individuals have a compromised immune system (immunocompromised), as well as, increased risk of autoimmune diseases. There are also locally disturbed immune responses caused by mental and/or physical exertion in patients with long-COVID.
4) SARS-CoV-2 causes genetic and epigenetic changes to your DNA. These changes include long term compromising of the immune system, increased risk of diabetes, hypertension, and cancer, as well as, damaging the neurological, circulatory, and cardiovascular systems. Any ailments for which you are predisposed will likely be elevated to the next stage (eg prediabetic –> diabetic).
5) Long-COVID is likely a combination of persistent virus, residual SARS-CoV-2 protein, epigenetic and genetic changes that may last indefinitely.
6) COVID reinfection further increases risks of death, hospitalization and damage to multiple organ systems and exacerbates underlying conditions including pulmonary, cardiovascular, hematological, diabetes, gastrointestinal, kidney, mental health, musculoskeletal and neurological disorders.

Niacin (nicotinic acid), zinc, and vitamin D are highly recommended to help reduce the severity of long term complications. I take take 25-50mg of niacin with each meal. Niacin does not stay in the bloodstream for more than a couple hours. Taking large doses once a day is not nearly as effective as taking small doses throughout the day. I crush zinc and allow it to linger in the mouth as it is better absorbed that way. Zinc lozenges are an alternative. Vitamin D is best obtained through a combination of a once-a-day supplement and limited exposure to sunlight. I radically changed my diet to enhance NAD+ production.

The increase in excess deaths and long-term amplification of genetic conditions indicates most COVID complications cannot be cured. Unfortunately, this means a shorter life-expectancy as well as a diminished quality of life. On October 26, 2023, Insurance News Network reported, “Excess mortality is the difference between the total number of deaths for a specific time period and the number that would have been expected. The numbers were naturally forecast to climb during the pandemic, but some industry and health authorities are concerned the rates haven’t greatly diminished as COVID infection rates have declined.”

Personally, it forever messed with my blood pressure, lipid profile, hepatic function panel, A1C, and others.

IMPORTANT NOTE: The reason I am aware of my condition is because I am actively researching long-COVID and am aggressively pursuing medical testing. If you had COVID, there is a 99% chance that you, too, have chronic conditions. SARS-CoV-2 causes genetic and epigenetic changes to your DNA. These changes include long-term compromising of the immune system, increased risk of diabetes, hypertension, and cancer, as well as, damaging the neurological, circulatory, and cardiovascular systems. Any ailments for which you are predisposed will likely be elevated to the next stage. See your doctor. Get all the tests you can especially blood work. If you have a family history of inherited genetic disorders, seek counsel from your physician. Many of the epigenetic changes are undetected for a year or two after infection; however, the sooner treatment is started, the better. Medications, diet, and other lifestyle changes can help treat the conditions, improve your quality of life, and increase your life expectancy.

High levels of cardiovascular issues have occurred in youth. We do not know why COVID causes this problem; however, it appears NAD+ is another common factor in the youth (in effect causing them to age faster/shortening life expectancy.) We don’t know if the two are related. Niacin is recommended to help stabilize NAD+.

Niacin is crucial to NAD+. COVID hijacks the precursors that create NAD+. Niacin is a substitute. Niacin does not cure the cause but it does treat the symptoms. At my worst symptoms, I was taking 500mg/day. After the vaccines were invented and I was vaccinated, most of my “long-COVID” symptoms (brain-fog, fatigue, inflammation, etc) subsided. Vaccination appears to have cured the persistent virus part of the disease. Several studies have shown post-infection vaccination treats persistent infection and “covid-19 vaccines might have protective and therapeutic effects on long-covid.” The epigenetic changes still persist, though. Now, I take 50mg/day to help my naturally aging NAD+. The most important part of the Niacin protocol is that you are really taking Niacin — nicotinic acid — NOT no-flush Niacin. If you are deficient in Niacin, you will flush. This will help you know you are taking the right supplement. Flushing is normal and will not harm you; nevertheless, you may want to start with a small dose to mentally prepare. The paper COVID, Vitamin B3 (Nicotinic Acid), and the Immune System helps explain Niacin in more detail.

Did you know that milk does not naturally contain vitamin D? How about that Niacin is added to breakfast cereals? This is because most Americans main source of vitamin D3 and Niacin (vitamin B3) is through their “fortified” breakfast foods. Chances are large you are starting deficient in D and Niacin. Both of these slow the aging process and help prevent diseases. Talk to your doctor about taking supplements.

Summary
Vaccinations may help treat the persistent virus and the residual SARS protein parts of long-COVID. In my case, that is what happened. Vaccination helped treat my “long-COVID symptoms” (fatigue, brain fog, lack of taste); however, I still have the genetic changes that increased my blood pressure and caused my blood labs to spike. Most people do not know that they have these genetic changes. Almost everybody that has had COVID has some form of long-COVID they just don’t know it. The problem appears to be worse in females (believed to be due to hormones.) Almost everybody has a compromised immune system that has had COVID.

10% of excess deaths are attributed to COVID. The other 90% are from COVID’s silent killers. Everyone that has had COVID is likely to have a diminished quality of life and a premature death. As Dr. Rob Wüst says, “There is something inside the body going wrong with the disease.”

Among the many epigenetic changes made by COVID is the down regulating of NAD+ and the hijacking of tryptophan resulting in physical and mental illnesses. Most individuals become deficient in
niacin (nicotinic acid), zinc, and vitamin D. It is likely that COVID causes epigenetic changes to predisposed conditions, so treatments will vary widely depending on your genes.

What is the call to action here? Just don’t get it? Or something else?
Yes. Both. Certainly avoid getting it at all costs. Do not get it multiple times. The virus works opposite of the typical virus where the immune system gains immunity strength fighting the infection. COVID compromises your immune system. Most people develop a form of autoimmune disease. Second, and just as important, is to start treatment ASAP. The virus WILL cause epigenetic changes to your genes triggering predisposed genes. For examples, I have seen people develop an iron deficiency likely because they were predisposed to iron-deficiency anemia. I have seen people develop pernicious anemia likely because they were predisposed to a B12 deficiency. I have seen people develop breast cancer that did have the breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) genes. People with a family history of cardiovascular conditions have had to double their medications. Several have suffered strokes or heart attacks. Quite a few people I know have turned pre-diabetic while other pre-diabetics have become diabetic. THE EARLIER YOUR INDIVIDUAL CONDITIONS ARE TREATED THE BETTER. Review your family health history. Get a medical physical. Insist on blood labs that include B12 and D. Change your diet as if you were diagnosed with cancer, cardiovascular conditions, high cholesterol, and diabetes. If you feel excess fatigue or brain fog after physical or mental exertion, stop that routine.

New Health Concern
COVID compromises your immune system. Now, I am seeing people having difficulty fighting the common cold and other typical illnesses. Often they are coming down with symptoms that last for weeks. Unfortunately, this is allowing weaker viruses to mutate in their body and become more efficient. At the same time, their immune systems are becoming weaker. A vicious downward health cycle for the planet. Perhaps you should be wearing a mask if you’ve had COVID in the past? After all, you are immunocompromised.

FOLLOW-UP QUESTIONS:
1. Is that the original vitamin stack (niacin plus) still the same or have you all updated it?
2. Is it for everyone who has had COVID or just if symptoms of long-COVID?
3. They comment about excess fatigue. Where are you going with that? Does post-COVID fatigue have a treatment?

1) I take take 25-50mg of niacin with each meal. Niacin does not stay in the bloodstream for more than a couple hours. Taking large doses once a day is not nearly as effective as taking small doses throughout the day. I crush 5mg of zinc twice-a-day and allow it to linger in the mouth as it is better absorbed that way. Zinc lozenges are an alternative. Vitamin D is best obtained through a combination of a once-a-day supplement and limited exposure to sunlight. I radically changed my diet to enhance NAD+ production.
2) Everyone who has had COVID. The symptoms of long-COVID are only about 1/3 of the disease. 2/3 of the disease are the “silent killers” and show no symptoms. 99% of people that have had COVID have genetic changes with negative health consequences.
3) My fatigue was part of the 1/3 of the disease with symptoms. In my case, it was being caused by persistent virus. Similar to HIV, COVID can covertly live and thrive undetected. Once I killed the persistent virus (by getting vaccinated), the chronic fatigue and brain fog were cured. However, all my epigenetic changes remain i.e. the silent killers e.g. elevated blood pressure, cholesterol, liver enzymes, etc.

Coronavirus: Science Based Information on the Covid-19 Virus

bookmark_borderDeadly Humid Heat in the USA

Deadly humid heat affects billions including the US Midwest this century. “It’s very disturbing,” study co-author Matthew Huber of Purdue University. “It’s going to send a lot of people to emergency medical care.”

The study Greatly enhanced risk to humans as a consequence of empirically determined lower moist heat stress tolerance was conducted by Purdue and George Mason University and published August 15, 2023.

These results indicate that a significant portion of the world’s population will experience — for the first time in human history — prolonged exposures to uncompensable extreme moist heat. Humans will struggle to adapt to these conditions in a warmer world as they will present widespread challenges across many aspects of food–energy–water security, human health, and economic development including in the world’s most populous and most vulnerable regions.

Climate Change and Health

What you can do today. How to save the planet.

Climate Change: The End of Times

The Human Induced Climate Change Experiment

bookmark_borderCOVID -19: Permanent Organ Damage

Update: February 21, 2025: Non-Hospitalized Long COVID Patients Exhibit Reduced Retinal Capillary Perfusion
In patients with long COVID, researchers found that the most significant change was a decrease in blood flow in the smallest blood vessels in the deeper layers of the retina. Researchers believe this decrease in circulation may reflect reduced blood flow in the brain, potentially leading to neurological symptoms.

“In oculomics—the field of study that examines the relationship between eye health and systemic diseases—we are understanding the power of the retina as a biomarker for disease, identifying early signs of diabetes, cardiovascular disease, and neurodegenerative disorders. It’s exciting to see how long COVID could fit into this framework,” said Dr. Gill. “Retinal imaging allows us to see the blood vessels that we cannot readily image elsewhere, so in this context, the eyes really are the ‘window to the soul.'”

“This finding bridges gaps between ophthalmology, neurology, and COVID-19, helping us better understand how inflammation affects different organs in the body,” said Manjot K. Gill, MD, senior author of the study and ophthalmology lead of the Northwestern Medicine Comprehensive COVID-19 Center. “The change in blood vessels in the deep part of the retina supports the hypothesis that long COVID affects similar blood vessels in other parts of the body, like the brain, which can potentially contribute to the symptoms of long COVID such as memory loss, brain fog and fatigue.”

Original Article
“Dr Betty Raman, from the University of Oxford and one of the lead investigators on the study, says it is clear that those living with long-COVID symptoms are more likely to have experienced some organ damage.”

The biggest impact was seen on the lungs, where MRI scans were 14 times more likely to show abnormalities. Scans were also three times more likely to show abnormalities in the brain, and twice as likely in the kidneys, among people who had severe COVID.

The article Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study was published September 22, 2023 in The Lancet Respiratory Medicine.

After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification.

ABOUT LONG-COVID
Long-standing multiorgan impairment following SARS-CoV-2 infection has been a major concern for individuals recovering from severe disease and is thought to be caused by a multitude of factors, including direct viral cytotoxicity, chronic inflammation, ischaemic injury, acute reactivation of other viruses, metabolic derangements, and acute treatment effects (especially invasive ventilation). Numerous reports of delayed organ complications such as myocarditis, stroke, and pulmonary emboli have led to speculations that the multiorgan dysfunction caused by COVID-19 might be responsible for impaired recovery and ongoing symptoms in individuals, a condition referred to as long COVID.

COVID-19 Chronic Conditions

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

bookmark_borderCorsi-Rosenthal Box: The Best Air Purifier

What is a Corsi-Rosenthal Box and how do you build one? The Corsi-Rosenthal Box is a simple DIY air filter and purifier that outperforms and can be more effective than expensive HEPA purifiers.

Corsi-Rosenthal Boxes are made from cardboard, tape, furnace air filters, and a box fan.

Corsi-Rosenthal Box
Corsi-Rosenthal Box

The Corsi-Rosenthal Box was invented by Richard Corsi, PhD, of the University of California-Davis and Jim Rosenthal, CEO of Tex-Air Filters.

“One night, I just scribbled out this idea on a piece of paper,” said Corsi. “It wasn’t an original idea – people had put a single filter on a box fan before. But not with MERV 13 filters.” (MERV — minimum efficiency reporting values — is the measure of how well a filter captures particles. The higher the MERV, the more effective the filter.)

“The Corsi-Rosenthal box outperformed the HEPA filter on every sized particle,” Rosenthal said. “You have such high flow from these fans, way more flow than you get out of a commercial HEPA filter. The air goes through the filter more than once in the same period of time. It may only get 50% of the particles at first. But the second time through, it’s getting much more.”

Corsi-Rosenthal Box Test

Smoke from wildfires in Canada brought record-breaking air pollution to the United States this spring, creating dangerous air quality from Bismarck, N.D., to Denver and Detroit to New York City and Washington. According to a Washington Post analysis of smoke data through June 7 (2023) from Stanford University, 197 air quality monitoring stations have reported all-time high pollution from wildfires.

During the Air Quality Crisis of 2023 the plant-based long-term breathing experiment failed the test. After 4 days in a row of Unhealthy (151 to 200 AQI) to Hazardous (301 and higher AQI) outdoor air quality, the the plant-filtered indoor air quality was unhealthy.

Even with spider plant filled windows and dozens of other plants, humans still suffered from itchy eyes, scratchy throats, and headaches.

Christopher suggested, “You should look into Corsi-Rosenthal… they consistently outperform high-end air filtration systems and it’s a simple DIY project.”

Sidd independently advised, “We are way beyond that (plant filtration). Put in something about Corsi-Rosenthal filters and CO2 monitors to judge ventilation.

Sooo… luckily I had a couple furnace filters, a box fan, and a case of beer. After constructing a crude Corsi-Rosenthal Box, the entire first floor was cleared of noticeable pollutants within 15 minutes. The itchy eyes, scratchy throat, and headache dissipated.

Makeshift / Emergency Corsi-Rosenthal Box
Makeshift / Emergency Corsi-Rosenthal Box

To confirm our results, we brought in the hound dog. Dogs are even more sensitive to air quality. After days of suffering in unhealthy air quality, the hound immediately laid down with his nose in the flow of the circulating Corsi-Rosenthal filtered air.

Conclusion
Air quality is already considered the number one contributing factor to death worldwide. Climate change is making poor air quality even more extreme. A combination of plant and Corsi-Rosenthal filtered air is recommended on a daily basis.

Our experiment was conducted in Southeastern Pennsylvania during an extreme air quality event; however, to our east is Philadelphia. The immediate Philadelphia area rarely has a day of Good air quality. Most summer days are Moderate to Very Unhealthy. To our west is Morgantown and Lancaster County. Even though Lancaster is a much more rural area, it continuously has some of the worst air quality in the world. So it doesn’t really matter where you live, implementing plant and Corsi-Rosenthal filtered air to the daily routine will likely improve your quality and quantity of life.

More on Clean Water, Air, and Healthy Plants
More Things You Can Do to Help the Environment and Your Health

 

bookmark_borderCOVID-19 Compromises Your Immune System (Immunocompromised)

By Daniel Brouse

SARS-CoV-2 and the results of COVID-19 cause long-term immune system dysfunction. That is to say COVID results in a compromised immune system.

* SARS-CoV-2 infection weakens immune-cell response
The magnitude and quality of a key immune cell’s response to vaccination with two doses of the Pfizer-BioNTech COVID-19 vaccine were considerably lower in people with prior SARS-CoV-2 infection compared to people without prior infection, a study has found. In addition, the level of this key immune cell that targets the SARS-CoV-2 spike protein was substantially lower in unvaccinated people with COVID-19 than in vaccinated people who had never been infected. Importantly, people who recover from SARS-CoV-2 infection and then get vaccinated are more protected than people who are unvaccinated. These findings suggest that the virus damages an important immune-cell response.

* Destruction of Good Gut Bacteria Resulting in a Compromised Immune System
Gut microbiome composition was significantly altered in patients with COVID-19 compared with non-COVID-19 individuals.

* Dysfunctional Kynurenine Pathway
“Targeted and untargeted metabolomics analyses identified altered tryptophan metabolism into the kynurenine pathway, which regulates inflammation and immunity.”

* Down Regulating NAD+
“NAD regulates the inflammatory response in immune and non-immune cells through Sirtuins. Epigenetic regulation of histones and non-histone proteins is induced by sirtuins and is essential for the development, reprogramming, and differentiation of the immune system and its related pathologies. A deregulation of the NAD+ levels has been associated with metabolic diseases and aging-related diseases, including neurodegeneration, defective immune responses, and cancer.”

* Up Regulating IDO
Indoleamine 2,3-dioxygenase (IDO) is an immune checkpoint molecule in the sense that it is an immunomodulatory enzyme produced by alternatively activated macrophages and other immunoregulatory cells. IDO is known to suppress T and NK cells, generate Tregs and myeloid-derived suppressor cells, and also supports angiogenesis.

* Rogue Antibodies
Autoantibodies are antibodies (immune proteins) that mistakenly attack a person’s own healthy tissues and organs. SARS-CoV-2 infection, is associated with many different clinical features that are commonly found in autoimmune diseases, including arthralgias, myalgias, fatigue, sicca, and rashes.

* Dysregulation of the innate immune system, i.e. “cytokine storm”
It is important to note that the severity of disease in humans is not determined only by virus replication but also by the host immune response to the infection, which may lead to dysregulation of the innate immune system, i.e. “cytokine storm” (Omicron SARS-CoV-2 can infect faster and better)

* Reinfection Greater Risks & Exacerbates Underlying Conditions
The evidence shows that reinfection further increases risks of death, hospitalization and damage to multiple organ systems. COVID exacerbates underlying conditions including pulmonary, cardiovascular, hematological, diabetes, gastrointestinal, kidney, mental heal<th, musculoskeletal and neurological disorders

* Post–COVID-19 Associated with Immune Cell Infiltration and Altered Gene Expression
COVID causes long-term immune dysfunction. “These findings indicate that T cell–mediated inflammation persists in the olfactory epithelium long after SARS-CoV-2 has been eliminated from the tissue, suggesting a mechanism for long-term post–COVID-19 smell loss.”

* Elevated Cytokines and Low Iron
Defects in iron homeostasis, dysregulated erythropoiesis contribute to inefficient oxygen transport, inflammatory imbalances, and persistent symptoms. The information on autoimmune diseases emphasizes that an excessive release of cytokines, which are signaling molecules involved in immune responses, can lead to an exaggerated inflammatory response. This heightened inflammation has the potential to damage tissues and contribute to autoimmune diseases, where the immune system mistakenly attacks healthy cells.

Also see: COVID-19: Increased Risk of Autoimmune Diseases

COVID-19 Index

bookmark_borderHealth and Climate Change: Health at the Mercy of Fossil Fuels

The Lancet released the report The 2022 report of the Lancet Countdown on health and climate change: health at the mercy of fossil fuels.

Q: Are millions of people already dying as a result of human induced climate change?
A: Yes.

Q: Can millions of people’s lives still be saved?
A: Yes, “a health-centred response can still deliver a thriving future if immediate action is taken.”
“The health impacts of multiple crises are being exacerbated by persistent fossil fuel dependence and putting additional strain on health systems. This is resulting in increased risk of food insecurity, infectious disease transmission, heat-related disease, energy poverty, and deaths from exposure to air pollution.”

A call to action
After 30 years of UNFCCC negotiations, the Lancet Countdown indicators show that countries and companies continue to make choices that threaten the health and survival of people in every part of the world. As countries devise ways to recover from the coexisting crises, the evidence is unequivocal. At this critical juncture, an immediate, health-centred response can still secure a future in which world populations can not only survive, but thrive.

Key findings of the 2022 report of the Lancet Countdown

  • • Climate change is undermining every dimension of global health monitored, increasing the fragility of the global systems that health depends on, and increasing the vulnerability of populations to the coexisting geopolitical, energy, and cost-of-living crises.
  • • Climate change is increasingly undermining global food security, exacerbating the effects of the COVID-19, geopolitical, energy, and cost-of-living crises. New analysis of 103 countries shows that days of extreme heat, increasing in frequency and intensity due to climate change, accounted for an estimated 98 million more people reporting moderate to severe food insecurity in 2020 than the average in 1981–2010 (indicator 1.4).
  • • Well-prepared health systems are essential to protect populations from the health impacts of climate change. However, global health systems have been drastically weakened by the effects of the COVID-19 pandemic, and the funds available for climate action decreased in 239 (30%) of 798 cities (indicator 2.1.3), with health systems increasingly being affected by extreme weather events and supply chain disruptions too.
  • • Insufficient climate change adaptation efforts have left health systems vulnerable to climate change-related health hazards. Only 48 of 95 countries have assessed their climate change adaptation needs (indicator 2.1.1) and only 63% of countries reported high to very high implementation status for health emergency management in 2021 (indicator 2.2.4). Increasing adaptation to climate change has the potential to simultaneously improve the capacity of health systems to manage both future infectious disease outbreaks and other health emergencies (indicator 2.3.1).
  • • Mitigation of the energy sector is crucial to keep the rise in global mean surface temperatures within the 1·5°C target set in the Paris Agreement. However, the energy sector is still heavily reliant on fossil fuels. Its carbon intensity decreased by less than 1% since the year the UNFCCC was signed, and a simultaneous increase in energy demand of 59% has increased total energy sector emissions to record high levels in 2021 (indicator 3.1). Now, as countries seek alternatives to Russian fossil fuels, many are backsliding to coal, and shifts in global energy supplies risk a net increase in fossil fuel production and consumption.
  • • The slow adoption of renewable energies, which contribute to only 2.2% of total global energy supply (indicator 3.1), means households remain vulnerable to highly volatile international fossil fuel markets, and millions lack access to reliable, clean sources of fuel. Traditional biomass accounts for 31% of the energy consumed in the domestic sector globally, and for 96% of that in low HDI countries (indicator 3.2). New analysis shows that the air in people’s homes in 62 countries analysed exceeded WHO guidelines for safe concentrations of small particulate air pollution (PM2·5) in 2020, by 30-fold on average (indicator 3.2). The current energy and cost-of-living crises, now threatens to worsen enery poverty.
  • • A new indicator this year reveals that, on the basis of their existing production strategies and market shares, 15 of the largest oil and gas companies would exceed their share of greenhouse gas emissions compatible with the 1·5°C climate target by an average of 87% (publicly-listed international companies) and 111% (state-owned national companies) in 2040 making the goals of the Paris Agreement unattainable (indicator 4.2.6).
  • • In 2019, 69 (80%) of 86 countries reviewed had net-negative carbon prices (ie, provided a net subsidy to fossil fuels) for a net total of US$400 billion. These subsidies exceeded 10% of national health spending in 31 countries and exceeded 100% in 5 countries (indicator 4.2.4). Meanwhile, climate efforts are being undercut by a profound scarcity of funding (indicator 2.1.1).
  • • A health-centred response to the coexisting climate, energy, and cost-of-living crises provides an opportunity to deliver a healthy, low-carbon future. Transitioning to clean energy and improved energy efficiency can avert the most catastrophic climate change impacts, while also improving energy security, supporting economic recovery, preventing the 1·2 million annual deaths resulting from exposure to fossil fuel-derived ambient PM2·5 (indicator 3.3), and improving health outcomes by promoting active forms of travel for greener cities. The associated reduction in the burden of disease will in turn reduce the strain on overwhelmed healthcare providers, and enable better care.
  • • The media, the scientific community, corporations, and country leaders are increasingly engaging in health and climate change (indicators 5.1–5.5), and new analysis shows that 86% of updated or new Nationally Determined Contributions now reference health (indicator 5.4).
  • • Countries are attempting to cut their dependence on international oil and gas supplies in response to the war in Ukraine and energy crisis, with some focusing on increasing renewable energy generation, raising hopes that a health-centred response could be emerging. However, the increased engagement and commitments must be urgently translated into action for hope to turn into reality.

Executive summary

The 2022 report of the Lancet Countdown is published as the world confronts profound and concurrent systemic shocks. Countries and health systems continue to contend with the health, social, and economic impacts of the COVID-19 pandemic, while Russia’s invasion of Ukraine and a persistent fossil fuel overdependence has pushed the world into global energy and cost-of-living crises. As these crises unfold, climate change escalates unabated. Its worsening impacts are increasingly affecting the foundations of human health and wellbeing, exacerbating the vulnerability of the world’s populations to concurrent health threats.

During 2021 and 2022, extreme weather events caused devastation across every continent, adding further pressure to health services already grappling with the impacts of the COVID-19 pandemic. Floods in Australia, Brazil, China, western Europe, Malaysia, Pakistan, South Africa, and South Sudan caused thousands of deaths, displaced hundreds of thousands of people, and caused billions of dollars in economic losses. Wildfires caused devastation in Canada, the USA, Greece, Algeria, Italy, Spain, and Türkiye, and record temperatures were recorded in many countries, including Australia, Canada, India, Italy, Oman, Türkiye, Pakistan, and the UK. With advancements in the science of detection and attribution studies, the influence of climate change over many events has now been quantified.

Because of the rapidly increasing temperatures, vulnerable populations (adults older than 65 years, and children younger than one year of age) were exposed to 3·7 billion more heatwave days in 2021 than annually in 1986–2005 (indicator 1.1.2), and heat-related deaths increased by 68% between 2000–04 and 2017–21 (indicator 1.1.5), a death toll that was significantly exacerbated by the confluence of the COVID-19 pandemic.

Simultaneously, the changing climate is affecting the spread of infectious diseases, putting populations at higher risk of emerging diseases and co-epidemics. Coastal waters are becoming more suitable for the transmission of Vibrio pathogens; the number of months suitable for malaria transmission increased by 31·3% in the highland areas of the Americas and 13·8% in the highland areas of Africa from 1951–60 to 2012–21, and the likelihood of dengue transmission rose by 12% in the same period (indicator 1.3.1). The coexistence of dengue outbreaks with the COVID-19 pandemic led to aggravated pressure on health systems, misdiagnosis, and difficulties in management of both diseases in many regions of South America, Asia, and Africa.

The economic losses associated with climate change impacts are also increasing pressure on families and economies already challenged with the synergistic effects of the COVID-19 pandemic and the international cost-of-living and energy crises, further undermining the socioeconomic determinants that good health depends on. Heat exposure led to 470 billion potential labour hours lost globally in 2021 (indicator 1.1.4), with potential income losses equivalent to 0·72% of the global economic output, increasing to 5·6% of the GDP in low Human Development Index (HDI) countries, where workers are most vulnerable to the effects of financial fluctuations (indicator 4.1.3). Meanwhile, extreme weather events caused damage worth US$253 billion in 2021, particularly burdening people in low HDI countries in which almost none of the losses were insured (indicator 4.1.1).

Through multiple and interconnected pathways, every dimension of food security is being affected by climate change, aggravating the impacts of other coexisting crises. The higher temperatures threaten crop yields directly, with the growth seasons of maize on average 9 days shorter in 2020, and the growth seasons of winter wheat and spring wheat 6 days shorter than for 1981–2010 globally (indicator 1.4). The threat to crop yields adds to the rising impact of extreme weather on supply chains, socioeconomic pressures, and the risk of infectious disease transmission, undermining food availability, access, stability, and utilisation. New analysis suggests that extreme heat was associated with 98 million more people reporting moderate to severe food insecurity in 2020 than annually in 1981–2010, in 103 countries analysed (indicator 1.4). The increasingly extreme weather worsens the stability of global food systems, acting in synergy with other concurrent crises to reverse progress towards hunger eradication. Indeed, the prevalence of undernourishment increased during the COVID-19 pandemic, and up to 161 million more people faced hunger during the COVID-19 pandemic in 2020 than in 2019. This situation is now worsened by Russia’s invasion of Ukraine and the energy and cost-of-living crises, with impacts on international agricultural production and supply chains threatening to result in 13 million additional people facing undernutrition in 2022.

A debilitated first line of defence

With the worsening health impacts of climate change compounding other coexisting crises, populations worldwide increasingly rely on health systems as their first line of defence. However, just as the need for healthcare rises, health systems worldwide are debilitated by the effects of the COVID-19 pandemic and the energy and cost-of-living crises. Urgent action is therefore needed to strengthen health-system resilience and to prevent a rapidly escalating loss of lives and to prevent suffering in a changing climate. However, only 48 (51%) of 95 countries reported having assessed their climate change adaptation needs (indicator 2.1.1) and, even after the profound impacts of COVID-19, only 60 (63%) countries reported a high to very high implementation status for health emergency management in 2021 (indicator 2.2.4).

The scarcity of proactive adaptation is shown in the response to extreme heat. Despite the local cooling and overall health benefits of urban greenspaces, only 277 (27%) of 1038 global urban centres were at least moderately green in 2021 (indicator 2.2.3), and the number of households with air conditioning increased by 66% from 2000 to 2020, a maladaptive response that worsens the energy crisis and further increases urban heat, air pollution, and greenhouse gas emissions.

As converging crises further threaten the world’s life-supporting systems, rapid, decisive, and coherent intersectoral action is essential to protect human health from the hazards of the rapidly changing climate.

Health at the mercy of fossil fuels

The year 2022 marks the 30th anniversary of the signing of the UN Framework Convention on Climate Change, in which countries agreed to prevent dangerous anthropogenic climate change and its deleterious effects on human health and welfare. However, little meaningful action has since followed. The carbon intensity of the global energy system has decreased by less than 1% since the UNFCCC was established, and global electricity generation is still dominated by fossil fuels, with renewable energy contributing to only 8·2% of the global total (indicator 3.1). Simultaneously, the total energy demand has risen by 59%, increasing energy-related emissions to a historical high in 2021. Current policies put the world on track to a catastrophic 2·7°C increase by the end of the century. Even with the commitments that countries set in the Nationally Determined Contributions (NDCs) updated up until November 2021, global emissions could be 13·7% above 2010 levels by 2030—far from the 43% decrease from current levels required to meet Paris Agreement goals and keep temperatures within the limits of adaptation.

Fossil fuel dependence is not only undermining global health through increased climate change impacts, but also affects human health and wellbeing directly, through volatile and unpredictable fossil fuel markets, frail supply chains, and geopolitical conflicts. As a result, millions of people do not have access to the energy needed to keep their homes at healthy temperatures, preserve food and medication, and meet the seventh Sustainable Development Goal (to ensure access to affordable, reliable, sustainable, and modern energy for all). Without sufficient support, access to clean energy has been particularly slow in low HDI countries, and only 1·4% of their electricity came from modern renewables (mostly wind and solar power) in 2020 (indicator 3.1). An estimated 59% of health-care facilities in low and middle-income countries still do not have access to the reliable electricity needed to provide basic care. Meanwhile, biomass accounts for as much as 31% of the energy consumed in the domestic sector globally, mostly from traditional sources—a proportion that increases to 96% in low HDI countries (indicator 3.2). The associated burden of disease is substantial, with the air in people’s homes exceeding WHO guidelines for safe concentrations of small particulate air pollution (PM2·5) in 2020 by 30-fold on average in the 62 countries assessed (indicator 3.2). After 6 years of improvement, the number of people without access to electricity increased in 2020 as a result of the socioeconomic pressures of the COVID-19 pandemic. The current energy and cost-of-living crises now threaten to reverse progress toward affordable, reliable, and sustainable energy, further undermining the socioeconomic determinants of health.

Simultaneously, oil and gas companies are registering record profits, while their production strategies continue to undermine people’s lives and wellbeing. An analysis of the production strategies of 15 of the world’s largest oil and gas companies, as of February 2022, revealed they exceed their share of emissions consistent with 1·5°C of global heating (indicator 4.2.6) by 37% in 2030 and 103% in 2040, continuing to undermine efforts to deliver a low carbon, healthy, liveable future. Aggravating this situation even further, governments continue to incentivise fossil fuel production and consumption: 69 (80%) of 86 countries reviewed had net-negative carbon prices (ie, provided a net subsidy to fossil fuels) for a net total of US$400 billion in 2019, allocating amounts often comparable with or even exceeding their total health budgets (indicator 4.2.4). Simultaneously, wealthier countries failed to meet their commitment of mobilising the considerably lower sum of $100 billion annually by 2020 as agreed at the 2009 Copenhagen Accord to support climate action in “developing countries”, and climate efforts are being undercut by a profound scarcity of funding (indicator 2.1.1). The impacts of climate change on global economies, together with the recession triggered by COVID-19 and worsened by geopolitical instability, could paradoxically further reduce the willingness of countries to allocate the funds needed to enable a just climate transition.

A health-centred response for a thriving future

The world is at a critical juncture. With countries facing concurrent crises, the implementation of long-term emissions-reduction policies risks being deflected or defeated by challenges wrongly perceived as more immediate. Addressing each of the concurrent crises in isolation risks alleviating one, while worsening another. Such a situation is emerging from the response to COVID-19, which has so far has not delivered the green recovery that the health community proposed, and, on the contrary, is aggravating climate change-related health risks. Less than one third of $3·11 trillion allocated to COVID-19 economic recovery is likely to reduce greenhouse gas emissions or air pollution, with the net effect likely to increase emissions. The COVID-19 pandemic affected climate action at the city level, and 239 (30%) of 798 cities reported that COVID-19 reduced financing available for climate action (indicator 2.1.3).

As countries search for alternatives to Russian oil and gas, many continue to favour the burning of fossil fuels, with some even turning back to coal. Shifts in global energy supplies threaten to increase fossil fuel production. Even if implemented as a temporary transition, these responses could reverse progress on air quality improvement, irreversibly push the world off track from meeting the commitments set out in the Paris Agreement, and guarantee a future of accelerated climate change that threatens human survival.

On the contrary, in this pivotal moment, a health-centred response to the current crises would still provide the opportunity for a low-carbon, resilient future, which not only avoids the health harms of accelerated climate change, but also delivers improved health and wellbeing through the associated co-benefits of climate action. Such response would see countries promptly shifting away from fossil fuels, reducing their dependence on fragile international oil and gas markets, and accelerating a just transition to clean energy sources. A health-centred response would reduce the likelihood of the most catastrophic climate change impacts, while improving energy security, creating an opportunity for economic recovery, and offering immediate health benefits. Improvements in air quality would help to prevent the 1·2 million deaths resulting from exposure to fossil fuel-derived ambient PM2·5 in 2020 alone (indicator 3.3), and a health-centred energy transition would enhance low-carbon travel and increase urban green spaces, promoting physical activity, and improving physical and mental health. In the food sector, an accelerated transition to balanced and more plant-based diets would not only help reduce the 55% of agricultural sector emissions coming from red meat and milk production (indicator 3.5.1), but also prevent up to 11·5 million diet-related deaths annually (indicator 3.5.2), and substantially reduce the risk of zoonotic diseases. These health-focused shifts would reduce the burden of communicable and non-communicable diseases, reducing the strain on overwhelmed health-care providers. Importantly, accelerating climate change adaptation would lead to more robust health systems, minimising the negative impacts of future infectious disease outbreaks and geopolitical conflicts, and restoring the first line of defence of global populations.

Emerging glimmers of hope

Despite decades of insufficient action, emerging, albeit few, signs of change provide some hope that a health-centred response might be starting to emerge. Individual engagement with the health dimensions of climate change, essential to drive and enable an accelerated response, increased from 2020 to 2021 (indicator 5.2), and coverage of health and climate change in the media reached a new record high in 2021, with a 27% increase from 2020 (indicator 5.1). This engagement is also reflected by country leaders, with a record 60% of 194 countries focusing their attention on the links between climate change and health in the 2021 UN General Debate, and with 86% of national updated or new NDCs making references to health (indicator 5.4). At the city level, local authorities are progressively identifying risks of climate change on the health of their populations (indicator 2.1.3), a first step to delivering a tailored response that strengthens local health systems. Although the health sector is responsible for 5·2% of all global emissions (indicator 3.6), it has shown impressive climate leadership, and 60 countries had committed to transitioning to climate-resilient and/or low-carbon or net-zero carbon health systems as part of the COP26 Health Programme, as of July, 2022.

Signs of change are also emerging in the energy sector. Although total clean energy generation remains grossly insufficient, record high levels were reached in 2020 (indicator 3.1). Zero-carbon sources accounted for 80% of investment in electricity generation in 2021 (indicator 4.2.1), and renewable energies have reached cost parity with fossil fuel energies. As some of the highest emitting countries attempt to cut their dependence on oil and gas in response to the war in Ukraine and soaring energy prices, many are focusing on increasing renewable energy generation, raising hopes for a health-centred response. However, increased awareness and commitments should be urgently translated into action for hope to turn into reality.

A call to action

After 30 years of UNFCCC negotiations, the Lancet Countdown indicators show that countries and companies continue to make choices that threaten the health and survival of people in every part of the world. As countries devise ways to recover from the coexisting crises, the evidence is unequivocal. At this critical juncture, an immediate, health-centred response can still secure a future in which world populations can not only survive, but thrive.

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bookmark_borderClimate Change: Viruses and Bacteria Reawaken

The proceeding of the Royal Proceedings released the report Viral spillover risk increases with climate change in High Arctic lake sediments.

Scientists in Canada wanted to investigate how climate change might affect spillover risk by examining samples from the Arctic landscape of Lake Hazen.

It is the largest lake in the world entirely north of the Arctic Circle, and “was truly unlike any other place I’ve been”, said researcher Graham Colby.

“It could be anything from ticks to mosquitoes to certain animals, to bacteria and viruses themselves,” said Lemieux.

“It’s really unpredictable… and the effect of spillover itself is very unpredictable, it can range from benign to an actual pandemic.”

The host spectrum of viruses is quite diverse, as they can sustainedly infect a few species to several phyla. When confronted with a new host, a virus may even infect it and transmit sustainably in this new host, a process called ‘viral spillover’. However, the risk of such events is difficult to quantify. As climate change is rapidly transforming environments, it is becoming critical to quantify the potential for spillovers. To address this issue, we resorted to a metagenomics approach and focused on two environments, soil and lake sediments from Lake Hazen, the largest High Arctic freshwater lake in the world. We used DNA and RNA sequencing to reconstruct the lake’s virosphere in both its sediments and soils, as well as its range of eukaryotic hosts. We then estimated the spillover risk by measuring the congruence between the viral and the eukaryotic host phylogenetic trees, and show that spillover risk increases with runoff from glacier melt, a proxy for climate change. Should climate change also shift species range of potential viral vectors and reservoirs northwards, the High Arctic could become fertile ground for emerging pandemics.

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bookmark_borderClimate Change: Flesh Eating Bacteria

The side effects of climate change are far reaching. Lee County, Florida is where hurricane Ian made landfall. Storm surges and subsequent flooding led to a spike in the potentially deadly infections caused by Vibrio vulnificus. The flesh eating species of bacteria is found in warm, brackish water.

One species, Vibrio vulnificus, can cause life-threatening wound infections. Many people with Vibrio vulnificus infection require intensive care or limb amputations, and about 1 in 5 people with this infection die, sometimes within a day or two of becoming ill.

Some Vibrio vulnificus infections lead to necrotizing fasciitis, a severe infection in which the flesh around an open wound dies. Some media reports call this kind of infection “flesh-eating bacteria,” said the CDC.

At least 29 cases and four deaths have been confirmed in Lee County this year as a result of such infections.

“The Florida Department of Health in Lee County is observing an abnormal increase in cases of Vibrio vulnificus infections as a result of exposure to the flood waters and standing waters following Hurricane Ian,” a spokesperson at the county health department said in a statement to CBS News on Monday, which noted that community members should “always be aware of the potential risks associated when exposing open wounds, cuts, or scratches on the skin to warm, brackish, or salt water.”

“Sewage spills, like those caused from Hurricane Ian, may increase bacteria levels,” the statement continued. “As the post storm situation evolves, individuals should take precautions against and infection and illness caused by Vibrio vulnificus.”

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