Climate Change and Pathogens

Posted on 2022/08/102022/08/10 by admin

In the report published in Nature entitled Over half of known human pathogenic diseases can be aggravated by climate change, data analyst and associate professor in the Department of Geography and Environment at the University of Hawaii Manoa, Camilo Mora, said climate hazards aggravated 58% of all known human pathogens. That is over half of infectious diseases discovered since the end of the Roman Empire.

A whopping 58% of an authoritative list of infectious diseases documented to have impacted humanity have already been shown to be aggravated by climatic hazards — a finding the researchers found “shocking,” Mora said.

Movement of people and animals caused by climate is one factor. Warming at higher latitudes allowed vectors and pathogens to survive winter is another factor. The report goes on to say, “The human pathogenic diseases and transmission pathways aggravated by climatic hazards are too numerous for comprehensive societal adaptations, highlighting the urgent need to work at the source of the problem: reducing GHG (Greenhouse Gas) emissions.”

This research reveals more evidence that humans will have difficulty adapting to climate change, especially those in developing countries, Mora said.

“The magnitude of the vulnerability when you think about one or two diseases — okay, sure, we can deal with that,” he said. “But when you’re talking about 58% of the diseases, and 58% of those diseases can be affected or triggered in 1,000 different ways. So that, to me, was also revealing of the fact that we’re not going to be able to adapt to climate change.”

Climate Change and Health

The Human Induced Climate Change Experiment

Rare Winter Air Quality Alert for Philadelphia

Posted on 2015/12/08 by admin

Philadelphia, PA — December 7 and 8, 2015 have been declared “don’t breath in Philly days” by the EPA. It is rare to have a December air quality alert in Philadelphia, PA. It is recommended not to breath in the out-of-doors on alert days. Children, elderly and physically active individuals are most at risk for disease and death.

View the current air quality for Philadelphia.

More on the health risks of air pollution.

Death By Ozone

More on global warming and climate change.

Ebola Virus Disease

Posted on 2014/08/29 by admin

The World Health Organization (WHO) believes the ebola outbreak is more severe than first thought. Because of fear and lack of education, many cases are going unreported. Ebola has a high instance of death due to bleeding from orifices.

“Ebola virus disease is a severe, often fatal illness and one of the world’s most virulent diseases. The infection is transmitted by direct contact with the blood, body fluids and tissues of infected animals or people. During an outbreak, people at higher risk of infection are health workers, family members and others in close contact with sick people and anyone who has died from Ebola. People who are ill with the disease need to receive expert care in appropriate facilities. Ebola outbreaks can devastate families and communities, but the infection can be controlled through the use of recommended protective measures. WHO is coordinating a global response to the latest outbreaks in Africa.”

Ebola virus disease (EVD), formerly known as Ebola haemorrhagic fever, is a severe, often fatal illness in humans.
EVD outbreaks have a case fatality rate of up to 90%.
EVD outbreaks occur primarily in remote villages in Central and West Africa, near tropical rainforests.
The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission.
Fruit bats of the Pteropodidae family are considered to be the natural host of the Ebola virus.
Severely ill patients require intensive supportive care. No licensed specific treatment or vaccine is available for use in people or animals.

Death Of Ash Trees

Posted on 2013/10/07 by admin

Ash trees are dying for a variety of reasons. In the USA, Emerald Ash Borer is killing many trees. In Europe, the fungus Chalara is spreading and killing trees.

More about the decline of the forests.

Emerald Ash Borer
The signs and symptoms of an EAB attack

The symptoms an ash tree shows when it is infested with emerald ash borer are similar to symptoms caused by other ash pests or diseases in Wisconsin.

For example, crown dieback can occur due to EAB damage, but can also be the result of drought stress, soil compaction or verticillium wilt, just to name a few.

Therefore, it is important to look for a combination of at least two symptoms or signs when trying to figure out if emerald ash borer is in your ash tree. If you see two or more from the lists below report your findings here.

Symptoms

Crown dieback: Dieback of the upper and outer crown begins after multiple years of EAB larval feeding. Trees start to show dead branches throughout the canopy, beginning at the top. Larval feeding disrupts nutrient and water flow to the upper canopy, resulting in leaf loss. Leaves at the top of the tree may be thin and discolored. An example of this is shown below.

Epicormic Sprouting: When trees are stressed or sick, they will try to grow new branches and leaves wherever they still can. Trees may have new growth at the base of the tree and on the trunk, often just below where the larvae are feeding. An example of this is shown in the picture above, where small branches are growing on the trunk, about 6 feet off the ground.

Bark splits: Vertical splits in the bark are caused due to callus tissue that develops around larval galleries. Larval galleries can often be seen beneath bark splits.

Woodpecker feeding: Woodpeckers eat emerald ash borer larvae that are under the bark. This usually happens higher in the tree where the emerald ash borer prefers to attack first. If there are large numbers of larvae under the bark the woodpecker damage can make it look like strips of bark have been pulled off of the tree. This is called “flecking.” An example of this is shown below.

Signs

D-shaped emergence holes: As adults emerge from under the bark they create a D-shaped emergence hole that is about 1/8 inch in diameter. An example of this is shown below.

S-shaped larval galleries: As larvae feed under the bark they wind back and forth, creating galleries that are packed with frass (larva poop) and sawdust and follow a serpentine pattern. An example of this is shown below.

Larvae: Larvae are cream-colored, slightly flattened (dorso-ventrally) and have pincher-like appendages (urogomphi) at the end of their abdomen. By the time larvae are done growing they are 1 1/2 inches long. Larvae are found feeding beneath the bark.

Adults: Adult beetles are metallic green and about the size of one grain of cooked rice (3/8 – 1/2 inch long and 1/16 inch wide). Adults are flat on the back and rounded on their underside.

Chalara
Description

Chalara dieback of ash is a serious disease of ash trees caused by a fungus called Chalara fraxinea (C. fraxinea), including its sexual stage, Hymenoscyphus pseudoalbidus (H. pseudoalbidus). The disease causes leaf loss and crown dieback in affected trees, and usually leads to tree death.
Threat

It is potentially a very serious threat. It has caused widespread damage to ash populations in continental Europe, including estimated losses of between 60 and 90 per cent of Denmark’s ash trees. We have no reason to believe that the consequences of its entering the natural environment in Britain would be any less serious. Experience on the Continent indicates that it kills young ash trees very quickly, while older trees tend to resist it for some time until prolonged exposure causes them to succumb as well.
Susceptible species

Chalara fraxinea is especially destructive of common ash (Fraxinus excelsior), including its ‘Pendula’ ornamental variety. Narrow-leaved ash (Fraxinus angustifolia) is also susceptible. Chalara dieback of ash is particularly destructive of young ash plants, killing them within one growing season of symptoms becoming visible. Older trees can survive initial attacks, but tend to succumb eventually after several seasons of infection.
Spread

Local spread, up to some tens of miles, may be by wind. Over longer distances the risk of disease spread is most likely to be through the movement of diseased ash plants. Movement of logs or unsawn wood from infected trees might also be a pathway for the disease, although this is considered to be a low risk.
Outbreak stage

Ash trees suffering with the infection have been found widely across Europe since trees believed to have been infected with this newly identified pathogen were reported dying in large numbers in Poland in 1992. These have included forest trees, trees in urban areas such as parks and gardens, and also young trees in nurseries.

In February 2012 it was found in a consignment of infected trees sent from a nursery in the Netherlands to a nursery in Buckinghamshire, England. Since then it has been found in young ash trees in a number and variety of locations in Great Britain, including urban landscaping schemes, newly planted woodland, and more nurseries.

In October 2012, Food & Environment Research Agency (FERA) scientists confirmed a small number of cases in Norfolk and Suffolk in ash trees at sites in the wider natural environment, including established woodland, which do not appear to have any association with recently supplied nursery stock. Further finds in trees in the wider environment have since been confirmed in a number of places, mostly on the eastern side of England and Scotland, and mostly concentrated in the south-eastern region of England. In May 2013 the first wider-environment case was found in south-west Wales, which is the farthest west site in Britain that a wider-environment case has been confirmed. (Map below)

C. fraxinea is now being treated as a quarantine pest under national emergency measures and any suspected sighting must be reported.

Hundreds of staff from government agencies checked ash trees across the UK for signs of the disease during early November 2012. It was one of several actions to emerge from a meeting of the Government’s emergency committee, COBR, chaired by Environment Secretary Owen Paterson.

Survey results

Plant health experts are also undertaking a survey of about a thousand sites which have received saplings from nurseries where Chalara dieback has been found.

National plans have been drawn up for Chalara.

The BRAIN Initiative

Posted on 2013/07/262013/07/26 by admin

Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative

What is the NIH BRAIN Initiative?

The NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is part of a new Presidential focus aimed at revolutionizing our understanding of the human brain. By accelerating the development and application of innovative technologies, researchers will be able to produce a revolutionary new dynamic picture of the brain that, for the first time, shows how individual cells and complex neural circuits interact in both time and space. Long desired by researchers seeking new ways to treat, cure, and even prevent brain disorders, this picture will fill major gaps in our current knowledge and provide unprecedented opportunities for exploring exactly how the brain enables the human body to record, process, utilize, store, and retrieve vast quantities of information, all at the speed of thought.

A map of overall task-fMRI brain coverage from the seven tasks used in the Human Connectome Project.

A map of overall task-fMRI brain coverage from the seven tasks used in the Human Connectome Project. Yellow and red represent regions that become more active in most participants during one or more tasks in the MR scanner; blue represents regions that become less active. Source: D.M. Barch for the WU-Minn HCP Consortium.

Top 10 Causes Of Death

Posted on 2012/12/13 by admin

A newly published study called “The Global Burden Of Disease” details the state of world health. Although the human lifespan is increasing, the amount of healthy years is not. The top ten causes of death are:

World	Deaths in millions	% of deaths
Ischaemic heart disease	7.25	12.8%
Stroke and other cerebrovascular disease	6.15	10.8%
Lower respiratory infections	3.46	6.1%
Chronic obstructive pulmonary disease	3.28	5.8%
Diarrhoeal diseases	2.46	4.3%
HIV/AIDS	1.78	3.1%
Trachea, bronchus, lung cancers	1.39	2.4%
Tuberculosis	1.34	2.4%
Diabetes mellitus	1.26	2.2%
Road traffic accidents	1.21	2.1%

Enough Space To Feel Sick

Posted on 2011/03/22 by admin

WASHINGTON, DC — Recent research aboard the space shuttle is giving scientists a better understanding of how infectious disease occurs in space and could someday improve astronaut health and provide novel treatments for people on Earth.

“With our space-based research efforts, including the International Space Station, we are not only continuing our human presence in space, but we are engaged in science that can make a real difference in people’s lives here on Earth,” said NASA Administrator Charles Bolden. “NASA’s leadership in human spaceflight allows us to conduct innovative and ground-breaking science that reveals the unknown and unlocks the mysteries of how disease-causing agents work.”

The research involves an opportunistic pathogen known as Pseudomonas aeruginosa, the same bacterium that caused astronaut Fred Haise to become sick during the Apollo 13 mission to the moon in 1970.

Scientists studying the bacterium aboard the shuttle hope to unlock the mysteries of how disease-causing agents work. They believe the research can lead to advanced vaccines and therapies to better fight infections. The findings are based on flight experiments with microbial pathogens on NASA shuttle missions to the International Space Station and appear in a recent edition of the journal Applied and Environmental Microbiology.

“For the first time, we’re able to see that two very different species of bacteria – Salmonella and Pseudomonas – share the same basic regulating mechanism, or master control switch, that micro-manages many of the microbes’ responses to the spaceflight environment,” said Cheryl Nickerson, associate professor at the Center for Infectious Diseases and Vaccinology, the Biodesign Institute at Arizona State University (ASU) in Tempe. “We have shown that spaceflight affects common regulators in both bacteria that invariably cause disease in healthy individuals [Salmonella] and those that cause disease only in people with compromised immune systems [Pseudomonas].”

By studying the global gene expression patterns in bacterial pathogens like Pseudomonas and Salmonella, Nickerson’s team learned more about how they react to reduced gravity.

Pseudomonas aeruginosa can coexist as a benign microbe in healthy individuals, but poses a serious threat to people with compromised immune systems. It is the leading cause of death for those suffering from cystic fibrosis and is a serious risk to burn victims. However, a high enough dosage of Salmonella typhimurium always will cause disease, even in healthy individuals.

During the initial study in 2006, two bacterial pathogens, Salmonella typhimurium and Pseudomonas aeruginosa, and one fungal pathogen, Candida albicans, were launched to the station aboard shuttles. They were allowed to grow in appropriately contained vessels for several days. Nickerson’s team was the first to evaluate global gene and protein expression (how the bacteria react at the molecular level) and virulence changes in microbes in response to reduced gravity.

“We discovered that aspects of the environment that microbes encountered during spaceflight appeared to mimic key conditions that pathogens normally encounter in our bodies during the natural course of infection, particularly in the respiratory system, gastrointestinal system and urogenital tract,” Nickerson said. NASA’s Advanced Capabilities Division Director, Benjamin Neumann added that, “This means that in addition to safeguarding future space travelers, such research may aid the quest for better therapeutics against pathogens here on Earth.”

The initial study and follow-on space experiments show that spaceflight creates a low fluid shear environment, where liquids exert little force as they flow over the surface of cells. The low fluid shear environment of spaceflight affects the molecular genetic regulators that can make microbes more infectious. These same regulators might function in a similar way to regulate microbial virulence during the course of infection in the human body.

“We have now shown that spaceflight conditions modified molecular pathways that are known to be involved in the virulence of Pseudomonas aeruginosa,” said Aurelie Crabbe, a researcher in Dr. Nickerson’s lab at ASU and the lead author of the paper. “Future work will establish whether Pseudomonas also exhibits increased virulence following spaceflight as did Salmonella.”

NASA’s Fundamental Space Biology Program sponsored and funded the research conducted by Crabbe and Nickerson along with their colleagues at the Biodesign Institute at ASU. They collaborated with the University of Colorado School of Medicine, University of Arizona, Belgian Nuclear Research Center, Villanova University, Tulane University, Affymetrix Inc, and NASA scientists.

For an abstract of the journal article on this research, visit:

http://www.ncbi.nlm.nih.gov/pubmed/21169425

For more information about NASA programs, visit:

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