Tag: NAD

bookmark_borderCOVID and DNA Damage-mediated PARP Activation

Posted on by admin

COVID-19 causes DNA damage. “DNA damage-mediated PARP activation is the cause of NAD+ depletion. The PARP1 inhibitor ABT-888 prevents the increase in PAR levels, NAD+ depletion and CaT loss. These findings confirm that DNA damage-mediated PARP activation is the cause of NAD+ depletion.

PARP1-mediated synthesis of ADP-ribose chains in turn depletes nicotinamide adenine dinucleotide (NAD+), induces further DNA damage and contractile dysfunction. Accordingly, NAD+ replenishment or PARP1 depletion precludes functional loss. Moreover, inhibition of PARP1 protects against tachypacing-induced NAD+ depletion, oxidative stress, DNA damage. [1]

COVID-long Haulers Syndrome is COVID-19 Induced Secondary Pellagra (CISP). NAD+ depletion causes the body to take drastic action to create more NAD+ including depleting niacin and tryptophan. Exercise or exertion results in PARP activation causing low NAD+. The exertion will cause cardiac problems from the nutritional deficiency and low serotonin from the use of tryptophan will cause problems with your metabolic regulation. Night sweats, intestinal upset, anxiety, and other symptoms are common.

COVID-19: NAD+ Protocol
NAD+ is a crucial part of the immune system. COVID depletes your NAD+. The body needs the time and materials necessary to replenish NAD+. Included in the elements you need are Niacin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium.

1) DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation

COVID-19 / SARS-CoV-2 / Novel Coronavirus Information

bookmark_borderNAD+ Plus Immune System Diet (CISP CPD)

Posted on by admin

By Daniel Brouse
help@membrane.com

THE NAD+ PLUS DIET (COVID Induced Secondary Pellagra and COVID Prevention Diet)

The NAD+ Plus Diet is based on research by Dr. Ade Wentzel (Port Elizabeth, South Africa), Robert Miller (Cape Town) and Guy Richards (Johannesburg). The team of scientist developed a diet based protocol that boosts NAD+ and the immune system.

THE PROTOCOL: Niacin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium

Boosting NAD+ is of particular importance when it comes to COVID-19. NAD+ (nicotinamide adenine dinucleotide) is in every cell of your body. NAD+ is involved in cell creation, maintenance, metabolism, and regulating cell processes. COVID both increases the breakdown of NAD+ and decreases the production of NAD+. If you have suboptimal NAD+ prior to contracting COVID, the coronavirus is likely to make the symptoms more severe and persist longer in duration (resulting in death.) Boosting your NAD+ can also help with aging, hypertension, type 2 diabetes, and most other ailments and illness.

By maintaining lifestyle and diet, COVID-19 can be prevented and/or shortened in severity and duration. COVID-long Haulers Syndrome can be cured. Long haulers syndrome is COVID-19 Induced Secondary Pellagra (CISP).

THE DIET TO BOOST THE IMMUNE SYSTEM WITH NAD+
Quercetin
Coffee and red wine are rich in Quercetin. Dieting can be fun. Quercetin is a bioflavonoid found in fruits and vegetables. There isn’t a Recommended Daily Allowance and the dosage depends on your weight; however, at least a 100mg per day is a good rule of thumb. 500-1000mg per day may be needed to boost NAD+. The highest levels are found in:

  • Onions 19.36mg per 100g serving [Red onion 32mg]
  • Dill (fresh) 55mg per 100g serving
  • Hot wax yellow peppers, raw 50mg per 100g serving
  • Radish leaves 70mg per 100g serving
  • Cilantro 53mg per 100g serving
  • Capers 173mg per 100g serving

Zinc
The Recommended Daily Allowance of Zinc is 10-15mg per day.

  • Water. Drinking water is rich in Zinc. Do not drink filtered water. Do not drink purified bottled water. Zinc is naturally present in water. The amount of Zinc in your water depends on the local geology and hydrologic cycle. The World Health Organization says, “In natural surface waters, the concentration of zinc is usually below 10 µg/litre, and in groundwaters, 10–40 µg/litre. In tapwater, the zinc concentration can be much higher as a result of the leaching of zinc from piping and fittings.” WARNING: If you live in an area where it is not safe to drink the water, or the zinc in the water is not sufficient, you may need to take a 10-15mg supplement.
    Nutrients In Drinking Water
    USDA Study shows regional mineral content of public and well water.
  • Meat and marine organisms contain 10–50 mg/kg wet weight

Vitamin C
The Recommended Daily Allowance of Vitamin C is 60mg per day. For NAD+ boosting, 500-1000mg may be required. Whole foods are recommended. Juicing may provide higher concentrations of Vitamin C; however, other nutritional benefits are lost in the process. You may need to supplement your diet with 500mg of Vitamin C per day.

  • Red pepper, sweet raw 95mg per 1/2 cup serving
  • Orange 70mg per serving
  • Broccoli cooked 39mg per 1/2 cup serving
  • Strawberries 49mg per 1/2 cup serving
  • Potato 17mg per 1/2 cup serving
  • Tomato 17mg mg per 1/2 cup serving

Vitamin D
The Recommended Daily Allowance of Vitamin D is 600-1,000iu per day. For NAD+ boosting, you may need to supplement your diet with 1,000-2,000iu of D3 per day. Few foods naturally contain vitamin D.

  • Sunlight. 15 minutes of sunshine per day. 90% of your body’s Vitamin D comes from the photosynthesis of sunlight to the skin. UVB light causes a reaction resulting in Vitamin D and other photoproducts essential for a healthy immune system. WARNING: UVB can cause cancer.
  • Fatty fish and seafood / Trout 645iu per serving
  • Mushrooms 366iu per 1/2 cup raw
  • Egg yolks 44iu per 1 scrambled egg
  • Fortified milk 120iu per cup

Selenium
The Recommended Daily Allowance of Selenium is 55mcg per day. Care should be taken not to overdose on Selenium. Consuming 50 Brazil nuts in one day can lead to selenosis resulting in breathing problems, heart attack, kidney failure, and death. Selenium supplements are not recommended.

  • Brazil nut 1 (one) 78mcg
  • Shrimp 3oz 40mcg
  • Chicken 3oz white meat 22mcg
  • Beef 3oz 18mcg

Niacin B3
The Recommended Daily Allowance of Niacin is 16mg per day. Niacin is your main precursor to creating NAD+. It is the most important component of the diet. It is also the most difficult to find sufficient quantities of in food. Most Americans get their Niacin from fortified breakfast cereal. Niacin is sprayed on the outside along with several other vitamins. It would take 100 bowls of Wheaties/day to correct a niacin deficiency. To obtain the amount of Niacin needed from a natural diet would require 4 pounds of liver a day or 62 pounds of cabbage (not recommended). You will likely need to supplement your diet with 50-100mg of Niacin per meal in order to boost your NAD+ and immune system. Nicotinic acid is essential, NOT nicotinamide.

  • Beef liver pan fried 3oz 15mg
  • Chicken breast 3oz 10mg
  • Marinara (spaghetti) sauce, ready to serve, 1 cup

Conclusion
Having survived COVID-19, I became inflicted with COVID-long Haulers Syndrome. After searching for a cause and a cure, I found The Vitamin and Mineral Protocol. The dosage depends on your age, weight, preexisting conditions, and what COVID has done to your body. The above diet is what cured me. You may need to increase the dosage of supplements.

COVID-19 Testimonial
Getting and Recovering from COVID.

The NAD+ Plus Immune Boosting Diet may treat other conditions. If you are on drugs to help regulate your preexisting conditions, you may need to reduce your dosage. Perhaps someone on Lisinopril for high blood pressure, or Warfarin to thin their blood, or maybe Metformin for their type 2 diabetes, should have concern that replenishing your NAD+ will cause the medication to be too strong. You should check with your doctor about lowering your dosage.

Robert Miller said, “Metaformin is a complex 1 inhibitor that will mess with NAD+ redox and NAD+ levels. As for lowering doses, yes, NAD+ boosting is highly likely to create a need to lower some medication but this must be done with a medical professional.”

Ade Wentzel added, “Quercetin and Warfarin should be monitored as the Warfarin effect may be changed. Nicotinic acid can reduce blood pressure and blood sugar in those with raised numbers so this needs to be monitored carefully.”

ADDITIONAL RESOURCES
COVID-19 / SARS-CoV-2 / Novel Coronavirus

COVID-19 Emergency Management Plan

COVID: The Cure?
Could Nicotinamide adenine dinucleotide (NAD+) be both a prophylactic and a treatment for COVID-19?

COVID-19: NAD+ Protocol
NAD+ is a crucial part of the immune system. COVID depletes your NAD+.
Included in the elements you need are Vitamin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium.

COVID Long Haulers Syndrome: NAD+ Deficiency
Research by Ade Wentzel, Robert Miller, and Guy Richards has found COVID-long (Long Haulers Syndrome) is a result of an NAD+ deficiency caused by SARS-CoV-2 (novel coronavirus).

bookmark_borderVitamin and Mineral Supplements

Posted on by admin

In general, you should get your vitamins and minerals in the food you eat and water you drink as part of your natural diet.

It is difficult to find a multivitamin that is good for you. Taking metals, such as, Iron, Sodium, Magnesium, Potassium, or Calcium as a supplement can be dangerous. Usually Zinc is on the list; however, very controlled amounts of Zinc are recommended for NAD+ deficiencies. Metals are not good in supplements unless advised by a doctor to treat a specific condition. Besides being toxic in supplement form, supplements bypass the important parts of nutrition and the digestive process. For instance, “Fiber is incredibly important. It leaves your stomach undigested and ends up in your colon, where it feeds friendly gut bacteria, leading to various health benefits. Certain types of fiber may also promote weight loss, lower blood sugar levels, and fight constipation.”

You should get all your minerals from the food and water you intake. When you get your minerals from the food you eat, they are part of the metabolic process. The same holds true for hormones and amino acids. Don’t take the supplement. Let your body create them — melatonin, tryptophan, serotonin, Vitamin D. “Essential minerals are most potent when they come from food. But if you’re struggling with deficiencies, you may need to take supplements. If so, use caution: ingesting too much of a mineral supplement can be harmful.” — Harvard Health “Precious metals and other important minerals for health”

The exception to this rule is if you want to prevent COVID or recover from COVID-19. A safe and effective prophylactic to prevent COVID, a treatment for active COVID cases, and a protocol for post-COVID long haulers syndrome is available. The primary ingredient is Niacin B3.

THE PROTOCOL
Niacin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium.

The following doses have cured severe deficiencies in COVID-long cases:
* Vitamin C, Quercetin and Selenium you can get from your diet. Careful not too much Selenium. One (1) Brazil nut a day is adequate Selenium.
* The Vitamin D is best gotten from 15 minutes a day in the sun. You can take 1000iu/day supplement, too.
* A 15mg Zinc/day supplement. Care should be taken not to overdose on Zinc. There are many zinc products which deliver different amounts of free zinc per milligram.
* The Niacin is the trickiest and most important part. You need to make sure you get the right kind of B3. Non-flush is no good. You can start with 35mg/day, but it will depend on your deficiency. The cured long hauler takes 100mg with each meal. (For a 6 month duration.)

Niacin is the most important ingredient in the protocol. Niacin is used to replenish NAD+. The other ingredients can not be processed without NAD+. Taking mega doses of Vitamin C or Vitamin D are of little to no help without NAD+.

The protocol was developed by Dr. Ade Wentzel (Port Elizabeth, South Africa), Robert Miller (Cape Town) and Guy Richards (Johannesburg). They developed the diet based protocol as a result of their research COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity.

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

bookmark_borderAfter You Recover from COVID-19 Induced Secondary Pellagra (CISP) Long Haulers

Posted on by admin

Research by Ade Wentzel, Robert Miller, and Guy Richards has found COVID-long (Long Haulers Syndrome) is COVID-19 Induced Secondary Pellagra (CISP) and is a result of an NAD+ deficiency caused by COVID-19.

You can boost your NAD+ levels with the Anti-COVID Protocol: Niacin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium

If you were NAD+ deficient prior to COVID and recovered using the Protocol, you should consult with your doctor about any preexisting conditions you were being treated for. If you were on drugs to help regulate your preexisting conditions, you may need to reduce your dosage. Perhaps someone on Lisinopril for high blood pressure, or Warfarin to thin their blood, or maybe Metformin for their type 2 diabetes, should have concern that replenishing your NAD+ will cause the medication to be too strong. You should check with your doctor about lowering your dosage.

Robert Miller said, “Metaformin is a complex 1 inhibitor that will mess with NAD+ redox and NAD+ levels. As for lowering doses, yes, NAD+ boosting is highly likely to create a need to lower some medication but this must be done with a medical professional.”

Ade Wentzel added, “Quercetin and Warfarin should be monitored as the Warfarin effect may be changed. Nicotinic acid can reduce blood pressure and blood sugar in those with raised numbers so this needs to be monitored carefully.”

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

bookmark_borderCOVID-19 Induced Secondary Pellagra (CISP) and the Coronavirus Code

Posted on by admin

By Daniel Brouse
help@membrane.com

Coronavirus / COVID

Three scientists from South Africa have cracked the COVID code. COVID Long Haulers Syndrome is COVID Induced Secondary Pellagra (CISP).

By treating the population for pellagra:
* many new COVID cases can be prevented (prophylactic)
* the severity and duration of COVID symptoms can be reduced
* COVID-long Haulers Syndrome can be treated

THE PROTOCOL: Niacin B3, Vitamin D, Vitamin C, Quercetin, Zinc, Methyltetrahydrofolate, and Selenium.

The dosage depend on your Niacin B3 deficiency. COVID causes a Niacin deficiency. In addition, many people are deficient prior to contracting COVID. These cases often end in death (aged, hypertension, obese, and type2 diabetics.)

The following doses have treated severe niacin and NAD+ deficiencies in COVID-long cases:
* Vitamin C, Quercetin and Selenium you can get from your diet. Careful not too much Selenium. One (1) Brazil nut a day is adequate Selenium.
* The Vitamin D is best gotten from 15 minutes a day in the sun. You can take 1000iu/day supplement, too.
* A 15mg Zinc/day supplement. Care should be taken not to overdose on Zinc. There are many zinc products which deliver different amounts of free zinc per milligram.
* Methyltetrahydrofolate 130-400ug/day
* The Niacin is the trickiest and most important part. You need to make sure you get the right kind of B3. Non-flush is no good. You can start with 35mg/day, but it will depend on your deficiency. The treated long hauler takes 100-150mg with each meal. Supplementation is still necessary for an undetermined amount of time.

Niacin is the most important ingredient in the protocol. Niacin is used to replenish NAD+. The other ingredients can not be processed without NAD+. Taking mega doses of Vitamin C or Vitamin D are of little to no help without NAD+.

The protocol was developed by Dr. Ade Wentzel (Port Elizabeth, South Africa), Robert Miller (Cape Town) and Guy Richards (Johannesburg). They developed the diet based protocol as a result of their research COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity.

This is not the first time the world has seen a pellagra epidemic. “In the early 1900s, pellagra reached epidemic proportions in the American South. Between 1906 and 1940 more than 3 million Americans were affected by pellagra with more than 100,000 deaths, yet the epidemic resolved itself right after dietary niacin fortification.” (Pellagra – Wikipedia)

In 2000, the World Health Organization developed an emergency management plan for pellagra.

WHO Pellagra Prevention and Control (PDF)

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

bookmark_borderCD38

Posted on by admin

COVID seeks out p53 deficient cells. That is the Tumour supressor gene.

https://pubmed.ncbi.nlm.nih.gov/25310288/
CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer

Abstract
Cervical cancer is the second most common cancer and the fifth most deadly malignancy in females worldwide, affecting 500,000 individuals each year. It is the leading cause of cancer mortality among women in developing countries. Dysregulated activation of genes, such as CD44, SOX9 and SKP2, plays a role in cervical cancer. CD38 is known to be involved in activities typical of cell surface receptors, such as signaling for activation and proliferation events and heterotypic cell adhesion. CD38 contributes to disease progression and relapse in certain tumors, such as acute myeloid and chronic lymphocytic leukemia. To the best of our knowledge, there is currently no report on the relationship between CD38 and cervical cancer. Using qPCR, immunohistochemistry, and western blot analysis, the expression levels of CD38 were investigated and found to be upregulated in cervical cancer. CD38 was correlated with dysregulation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway in cervical cancer tissues in vitro. At the same time, CD38 overexpression affected the expression of PI3K, Akt, MDM2 and p53 in vivo. The results of the present study suggested that CD38 is highly expressed in cervical carcinoma tissues and play an important role in dysregulation of the PI3K/Akt signaling pathway.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226059/
The Many Facets of CD38 in Lymphoma: From Tumor–Microenvironment Cell Interactions to Acquired Resistance to Immunotherapy
Abstract

The CD38 antigen is expressed in several hematological malignancies, and the anti-CD38 monoclonal antibodies Daratumumab and Isatuximab have an established role in the therapy of multiple myeloma. However, data on the therapeutic utility of CD38 targeting in other lymphoid malignancies are limited. In chronic lymphocytic leukemia, the prognostic significance of CD38 expression is well accepted, and preclinical studies on the use of Daratumumab in monotherapy or combination therapy have demonstrated considerable efficacy. In other lymphoproliferative disorders, preclinical and clinical data have not been as compelling; however, CD38 overexpression likely contributes to resistance to checkpoint inhibitors, prompting numerous clinical trials in Hodgkin and non-Hodgkin lymphoma to investigate whether blocking CD38 enhances the efficacy of checkpoint inhibitors. Furthermore, due to its widespread expression in hematological tumors, CD38 represents an attractive target for cellular therapies such as CAR-T cells. The present review discusses current knowledge of CD38 expression and its implications in various lymphoid malignancies. Furthermore, it addresses current and future therapeutic perspectives, with a particular emphasis on the significance of CD38 interaction with immune cells of the tumor microenvironment. Lastly, results of ongoing studies using anti-CD38 antibodies will be reviewed.
Keywords: CD38, lymphoma, Daratumumab, immunoescape, checkpoint inhibitors

bookmark_borderCOVID-19 Emergency Management Plan

Posted on by admin

COVID
by Daniel Brouse
Email: help@membrane.com

THE COVID CRISIS
COVID-19, the SARS-CoV-2 Novel Coronavirus, is resulting in hundreds-of-thousands of deaths and millions of chronic medical conditions. A safe and effective prophylactic to prevent COVID, a treatment for active COVID cases, and a protocol for post-COVID long haulers syndrome is available. The primary ingredient is Niacin B3 and costs only pennies per day.

Research by Ade Wentzel, Robert Miller, and Guy Richards has found COVID-long (Long Haulers Syndrome) is a result of an NAD+ deficiency caused by COVID-19. [1] The protocol for treating NAD+ deficiencies has been found to be safe and effective in a study conducted on mice. [2}

THE PROTOCOL
Niacin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium

URGENT AID TO THE MOST VULNERABLE
The research proves that people with a preexisting NAD+ (nicotinamide adenine dinucleotide) deficiency are at the highest mortality risk — aged, obese and type2 diabetics. Using the Ade/Miller protocol as a prophylactic can substantially reduce mortality in the predisposed.

THE GENERAL POPULATION
The public at large can also benefit from the protocol. The severity and duration of COVID-19 symptoms can be greatly minimized by maintaining NAD+ in the body. Symptoms of long haulers can be treated and cured.

THE SYMPTOMS
NAD+ is involved in cell creation, maintenance, metabolism, and regulating cell processes. COVID both increases the breakdown of NAD+ and decreases the production of NAD+.

Symptoms of a NAD+ deficiency may include:
* difficulty breathing (feeling like you’re not taking in enough oxygen)
* congestion / cough
* stomach issues / nausea / diarrhea
* loss of taste, smell, and appetite
* body temperature regulation, fever, night sweats, chills
* nightmares / vivid dreams
* brain fog / dizziness / the spins
* headaches / body aches / soreness
* fatigue
* ear aches
* skin lesions
* anxiety or depression

The protocol addresses all these ailments. A niacin supplement is the cheapest and safest treatment.

PELLAGRA
A niacin deficiency results in pellagra. Emergency plans for treating pellagra have already been developed in both the United States and worldwide. Long haulers syndrome is COVID-19 Induced Secondary Pellagra (CISP).

Pellagra was first identified among Spanish peasants by Don Gaspar Casal in 1735. Pellagra has sometimes been called the disease of the four D’s – dermatitis, diarrhoea, dementia, and death. [3] Pellagra was in existence for nearly two centuries in Europe before being recognized in the United States, where it was first reported in 1902. Over the next two decades, pellagra occurred in epidemic proportions in the American South. [4] By the time of the Mississippi flood in 1927, Dr Joseph Goldberger of the USPHS had conducted extensive research demonstrating that pellagra was caused by a nutritional deficiency (a lack of niacin, or vitamin B3). Goldberger advised the Red Cross to add brewer’s yeast to its food rations. Within weeks, people with pellagra were cured, and new cases of pellagra were prevented. [5]

WORLD EMERGENCY MANAGEMENT PLAN
In 2000, the World Health Organization developed an emergency management plan for pellagra.

WHO Pellagra Prevention and Control (PDF)

Cases of pellagra “responded dramatically both to nicotinic acid.”  Because several forms of niacin are available to the body, and tryptophan can be converted to niacinat the ratio of 60 mg of tryptophan to 1 mg niacin, the term “niacin equivalent” is used to describe the contribution to dietary intake of all active forms of niacin. Niacin is a member of the B-vitamin complex group.

CONCLUSION
A large quantity and quality of lives could be saved by implementing the protocol of Niacin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium.

1. COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity Wentzel, Miller, Richards
COVID-19: NAD+ Deficiency by Wentzel, Miller, Richards (PDF)

2. Treatment of SARS-CoV-2 induced pneumonia with NAD+ in a mouse model Jiang, Deng, Ma, Pang, Hu, Qin, Xu
COVID-19 in Mice / NAD+ (PDF)

3. Joseph Goldberger’s research on the prevention of pellagra Alfredo Morabia

4. Pellagra in the United States: a historical perspective NIH

5. Preventing Chronic Diseases CDC

bookmark_borderCOVID-19 Long Haulers Syndrome and NAD+ Deficiency

Posted on by admin

COVID
by Daniel Brouse
Email: help@membrane.com

Research by Ade Wentzel, Robert Miller, and Guy Richards has found COVID-long (Long Haulers Syndrome) is a result of an NAD+ deficiency caused by SARS-CoV-2 (novel coronavirus). [1] The study Treatment of SARS-CoV-2 induced pneumonia with NAD+ in a mouse model confirms the team’s findings. “Our in vivomouse study supports trials for treating COVID-19 patients with NAD+ or its precursors.” [2] The onset of symptoms in “waves” over a period of weeks is likely secondary to exercise (probably consumption of NAD+.)

Nicotinamide adenine dinucleotide (NAD+) is an essential part of the body’s immune system. NAD+ is involved in cell creation, maintenance, metabolism, and regulating cell processes. COVID both increases the breakdown of NAD+ and decreases the production of NAD+.

Long haulers’ symptoms can be traced to a lack of the NAD+ building blocks, as well as, unregulated NAD+ cell processes.

Pellagra = NAD+ and tryptophan deficiency (nicotinic acid, niacin)
Breast = oxytocin
BP = vasopressin
Serotonin = tryptophan
Muscle cramps = calcium metabolism

A COVID NAD+ deficiency can cause a lack of serotonin regulation resulting in a lack of body temperature regulation. Ade Wentzel said, “NAD+ deficiency causes a lack of Tryptophan which is used for serotonin production and hence temperature… really the same as pellagra. The brain fog is part of low NAD+ and tryptophan. [3] If you have a NAD+ deficiency before contracting COVID, it could kill you.” Pellagra is a multiple-deficiency disease associated with diets providing low levels of niacin and/or tryptophan and often involving other B vitamins resulting in changes in the skin, gastrointestinal tract, and nervous system. Skin lesions, gastrointestinal lesions (including nausea, excessive salivation, a burning sensation in the epigastrium, and diarrhoea), and nervous lesions (including anxiety, depression, and fatigue; later symptoms include apathy, headache, dizziness, irritability and tremors) are all symptoms of pellagra and CISP (Covid Induced Secondary Pellagra). [4}

PROTOCOL
At this point in time, the safest and most effective treatment is to replenish the body’s NAD+. The most important building block is Niacin (B3). Care should be taken in obtaining the correct kind of B3. Robert Miller offered, “Avoid Inositol Nicotinate (non-flushing B3).” Ade added, “We suggest you use nicotinic acid (niacin B3). We also believe it works most directly to increase NAD+. Niacin doesn’t cause liver problems. Non-flush niacin does though.” (Robert and Ade’s Guide to Niacin)

“Some people respond really quickly to the protocol, and some really slowly needing bigger nicotinic acid doses. Different symptoms respond at different speeds. You may have to supplement for 6 months still,” notes Ade.

The complete Miller/Wentzel/Richards “COVID NAD+ protocol” to correct a NAD+ deficiency:
NAD+ = nicotinic acid (niacin B3), Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus
1. COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity Wentzel, Miller, Richards
COVID-19: NAD+ Deficiency by Wentzel, Miller, Richards (PDF)

2. Treatment of SARS-CoV-2 induced pneumonia with NAD+ in a mouse model Jiang, Deng, Ma, Pang, Hu, Qin, Xu
COVID-19 in Mice / NAD+ (PDF)

3. Joseph Goldberger’s research on the prevention of pellagra Alfredo Morabia

4. PELLAGRA and its prevention and control in major emergencies WHO
Pellagra Prevention and Control

bookmark_borderCOIVD-19 and Serotonin

Posted on by admin

I am a researcher sharing covid19 information and connecting people together for solutions. I saw your research and the suggested protocol to support NAD+ pathways and it really resonated as it would also support serotonin synthesis. A number of researchers believe all COVID19 issues come from serotonin dysregulation.

I would love to get your anecdotal observations on how a vitamin stack has helped long haulers, I have heard a number of them have fully recovered after taking niacin, vitD, vitC, selenium and quercetin stack.

Interesting that zinc, selenium, vitD, vitamin B3, vitC – are all support serotonin synthesis and quercetin up regulates it and stabilizes mast cells.

It seems like the dots are connecting and I would love to hear from you, here is a blog post I wrote to promote serotonin theory:

Nikita K. Alexandrov, Bchem, MBA

https://nkalex.medium.com/blood-dysfunction-as-the-cause-of-long-covid-926c0af4ea63

Disruption of Blood Dynamics and Gut-Immune-Brain Axis as the Cause of Long Covid
Disruption of Blood Dynamics and Gut-Immune-Brain Axis as the Cause of Long Covid

 

 

bookmark_borderInterferons Interfere With Disease

Posted on by admin

by Daniel Brouse

An interferon is a protein released by animal cells, usually in response to the entry of a virus, which has the property of inhibiting virus replication. A natural substance that helps the body’s immune system fight infection and other diseases, such as cancer. Interferons are made in the body by white blood cells and other cells, but they can also be made in the laboratory to use as treatments for different diseases. In cancer therapy, interferons may help keep cancer cells from growing and may help kill cancer cells. There are three main types of interferons: interferon-alfa, interferon-beta, and interferon-gamma. An interferon is a type of cytokine and type of immunomodulating agent. [1]

Several new studies of immune response to SARS-CoV-2, the virus that causes the disease, suggest timing could be critical for interferons. These immune proteins suppress viral replication early in disease. Yet if they are active later, some scientists think they can exacerbate the harmful inflammation that forces some COVID-19 patients onto life support. Interferons are “a double-edged sword,” says immunologist Eui-Cheol Shin of the Korea Advanced Institute of Science and Technology. [2]

The timing of the creation and the implementation of interferons appears to be a critical part of the immune system. Synthetic interferons may do more harm than good. Synthesizing and synergizing interferons by the body may be a safe and effective way to boost the nonspecific immune system. It may also be a safe and effective way to boost the specific immune system.

Memory T cells are created when a naive T cell acquires the memory of an antigen. Acquired T cell responses are critical for the host’s defense against microbial pathogens. T cells, by the release of interferon-γ (IFN-γ), induce autophagy, phagosomal maturation, the production of antimicrobial peptides such as cathelicidin, and antimicrobial activity. There is a a mechanism in which vitamin D is required for acquired immunity to overcome the ability of intracellular pathogens to evade macrophage-mediated antimicrobial responses.[3]

While the inflammation generated by innate immune cells [neutrophils, macrophages, monocytes, natural killer (NK) cells, dendritic cells (DCs), etc.] is important in the initial containment of the infection, it also informs and directs the expansion and differentiation of adaptive immune cells. Responding to the inflammatory environment created by the innate response, cells of the adaptive arm of the immune response (B cells, αβ T cells, and γδ T cells) are stimulated to expand in number (proliferate) and to differentiate into cells with a range of functions appropriate for the immunological challenge.[4]

What is necessary for the creation and implementation of interferons?

The role of eating meat in your diet is not yet clearly known; however, animal proteins and amino acids obtained through eating meat likely play an important role in creating interferons. We do know that bacterium found in ruminant cattle (meat and milk) is essential for humans to make Vitamin D. [5] We also know that exposure of the skin to sunlight (UVB radiation) is required for the body to photosynthesize Vitamin D and create the photoproducts. Previtamin D3 and vitamin D3 also absorb UV B radiation and are converted into a variety of photoproducts some of which have unique biologic properties. [6]

“We’ve discovered a new component of the interferon system,” said Michael J. Holtzman, MD, the Selma and Herman Seldin Professor of Medicine. “It does something that other components don’t do, and it works on both sides of the fence: It dials up the body’s internal genes that fight viruses, and it attacks viral proteins directly.”

The researchers’ strategy did not involve increasing the amount of interferon, the first step of this important antiviral signaling cascade. Instead, it dialed up amounts of the protein STAT1, the second component of this cascade, without altering the system’s overall interferon on/off switch.

“Past work to boost this system just kept the interferon signal on all the time,” Holtzman said. “When the system is chronically activated, it is no longer regulated, and that’s where the autoimmune problems may come from. Our system is still regulated by the presence or absence of interferon. Interferon amounts increase when there is an infection and decrease when there is no infection. We’re not boosting interferon itself, but the secondary signal that interferon activates, which sets off the rest of the antiviral cascade. It’s like greasing the wheels. We’re not pushing the system any harder. But when we do push, we get a bigger effect.” [7]

COVID, Vitamin D, Health, and Wellness

Vitamin D, Sunlight, the Season, and People of Color

Your Immune System and Photosynthesized Vitamin D

1. Interferon National Cancer Institute
2. An Immune Protein Could Prevent Severe COVID-19—if It Is Given at the Right Time Scientific American
3. Vitamin D Is Required for IFN-γ–Mediated Antimicrobial Activity of Human Macrophages NIH
4. T cell responses: naïve to memory and everything in between NIH
5. Dr. Karl Kruszelnicki Podcast / Australian Broadcasting Corporation

6. Sunlight and Vitamin D NIH
7. Study reveals new, potent way to boost immunity and fight viruses​​​ Washington University in St.Louis