Post Acute Sequelae of SARS-CoV-2 (PASC)

COVID Vaccine Breakthrough Cases

Posted on 2021/08/232021/08/23 by admin

by Daniel Brouse
August 23, 2021
help@membrane.com

Q: Why are there so many breakthrough cases of COVID in the vaccinated?

A: There are several reasons why there are breakthrough cases with any vaccine; however, COVID is different. Many of the vaccinated people getting COVID already had COVID prior to being vaccinated. This is the second time they have contracted the virus.

Once you have had COVID, your immune system is compromised. You should consider yourself immune compromised. The vaccine will not fully compensate for that fact. COVID damages your immune system. The virus makes your antibodies dysfunctional. The virus suppresses your memory T cells. The virus does a lot more to thwart an immune response. So though you may have the antibodies, maybe even lots and lots of antibodies, you’ve got Nobody’s At Home Syndrome. There is little to no immune response regulation nor coordination. This is also why natural immunity through infection is impossible. COVID erases the memory from your memory cells, so to speak. It can’t even remember itself.

Q: Is this a hallmark of the virus? I mean is this finding in all post COVID cases?

A: Yes. Severity of illness does not appear to be a factor (mild cases to severe all exhibit similar compromises to the immune system.) The exception is asymptomatic cases. We still don’t know about asymptomatic cases. The evidence is pointing to all cases that progress past the nasal passage result in immunocompromised individuals. There also is a small percentage (1 in 100,000) of people that appear to evade impact.

The scientific community is looking for ways to cure the problems. So far, there is only some success in treating the symptoms. There is nothing else to really compare to long-COVID. A similar condition happens to some measles survivors that bares a slight resemblance in T cell response, but it is not same. “Measles induces immune suppression through a process called immune amnesia. Studies in non-human primates revealed that MV actually replaces the old memory cells of its host with new, MV-specific lymphocytes. As a result, the patient emerges with both a strong MV-specific immunity and an increased vulnerability to all other pathogens.” COVID appears to use a different process that involves T cell suppression. There is also some similarity to HIV. “HIV attacks a specific type of immune system cell in the body. It’s known as the CD4 helper cell or T cell. When HIV destroys this cell, it becomes harder for the body to fight off other infections.” Again, COVID appears to use a different mechanism to suppress T cells.

Q: What do we know about the immune system post-COVID?

A: We know at least two important pieces of the puzzle:
1) The SARS-CoV-2 causes gene expressions in the host that result in dysfunctional NAD+. The virus makes it harder for the body to create NAD+ and also increases the breakdown in NAD+. “NAD regulates the inflammatory response in immune and non-immune cells through Sirtuins. Epigenetic regulation of histones and non-histone proteins is induced by sirtuins and is essential for the development, reprogramming, and differentiation of the immune system and its related pathologies. A deregulation of the NAD+ levels has been associated with metabolic diseases and aging-related diseases, including neurodegeneration, defective immune responses, and cancer.” — NAD-immune-system

2) The SARS-CoV-2 causes gene expressions in the host that result in upregulation of IDO (Indoleamine-2,3-dioxygenase). “IDO is an immune checkpoint molecule in the sense that it is an immunomodulatory enzyme produced by alternatively activated macrophages and other immunoregulatory cells. IDO is known to suppress T and NK cells, generate Tregs and myeloid-derived suppressor cells, and also supports angiogenesis.’ (Wikipedia)

Q: How long do these gene expressions (epigenetics) last? How long does long haulers syndrome last?

A: We don’t know how long post-COVID cases will suffer with a compromised immune system. Long-COVID patients from January of 2020 are still immune compromised. It is possible the genetic changes will never revert.

COVID in Your Genes

COVID-19 Delta Variant and Vaccines

COVID-19 Delta Variant and Vaccines

Posted on 2021/08/012021/08/12 by admin

By Daniel Brouse

What do we know about the Delta variant and vaccines?

OVERVIEW
The efficacy of mRna vaccines is about 79% against contracting the Delta variant. Non-mRna vaccines are between 40-60% effective against Delta. Vaccines lose efficacy at about 3%/month after six months of being fully vaccinated. Vaccines appear to help contain the Delta variant to the nasal passage. You are less likely to develop the epigenetic changes to your genes (long-COVID). Previous infection of COVID offers no protection to the Delta variant. Get vaccinated.

THE BAD NEWS
The delta variant is much more contagious than any other COVID strain. Vaccines also appear to be less effective at preventing infection from the Delta variant. On July 30, 2021, the Delta variant was much more predominant in Louisiana than in Pennsylvania. In Louisiana, 15% of the deaths were in vaccinated individuals. In Pennsylvania, 1% of the deaths were in vaccinated individuals.

Recent studies also revealed that vaccinated people can transmit the virus both asymptomatically and symptomatically.

THE GOOD NEWS
The vaccines are still tremendously effective at preventing infection, hospitalization and death from Delta.

Vaccinated individuals that get infected with Delta overwhelmingly stop the virus in their nasal passage. The virus never infects the lungs nor spreads to other systems causing blood clots or other life threatening conditions.

Since Delta never reaches the lungs and other organs, vaccinated people that test positive for COVID are unlikely to develop long-COVID (Long Haulers Syndrome). Long-COVID is caused by the coronavirus making epigenetic and genetic changes to your genes. COVID partially disables the immune system. Some of the dismantling is temporary lasting only a few days. Some of the dismantling is chronic and may last a lifetime.

The most common long term side-effect from COVID-19 are:
* the disruption of the body’s ability to produce and retain NAD+. Without NAD+ your immune system can not metabolize most vitamins, can not regulate body temperature, nor properly activate an immune response. Lack of NAD+ will cause your body to hi-jack tryptophan and cause all sorts-of mental and neurological disorders. Lack of NAD+ has been associated with over one hundred post-COVID ailments.
* upregulation of Indoleamine 2,3-dioxygenase (IDO). “IDO is an immune checkpoint molecule in the sense that it is an immunomodulatory enzyme produced by alternatively activated macrophages and other immunoregulatory cells. IDO is known to suppress T and NK cells, generate Tregs and myeloid-derived suppressor cells, and also supports angiogenesis.’

In the vast majority of cases, vaccinated individuals do not suffer from alterations to the genes. Vaccination almost always prevents Delta from developing into long-COVID’s Long Haulers Syndrome.

PROTECT YOUR GENES FROM THE VIRUS
GET VACCINATED
WEAR A MEDICAL GRADE MASK (to prevent the virus from getting in your nasal passage in the first place)
TAKE A NIACIN SUPPLEMENT
AVOID ANTI-VAXXERS LIKE THE PLAGUE

Post-Acute COVID-19 — COVID Long Haulers Syndrome

Posted on 2021/07/122021/07/14 by admin

Guy A. Richards1, Adrian Wentzel2, Robert Miller

COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity Wentzel, Miller, Richards
COVID-19: NAD+ Deficiency by Wentzel, Miller, Richards (PDF)

Treatment of SARS-CoV-2 induced pneumonia with NAD+ in a mouse model Jiang, Deng, Ma, Pang, Hu, Qin, Xu
COVID-19 in Mice / NAD+ (PDF)

Post-Acute COVID-19 Sequelae

AIMMS seminar 23 June | Role of NAD+ in (long)Covid - Part 1: Prof. Guy Richards - Clinical perspective — AIMMS seminar 23 June | Role of NAD+ in (long)Covid – Part 1: Prof. Guy Richards – Clinical perspective

AIMMS seminar 23 June | Role of NAD+ in (long)Covid – Part 2: Dr. Ade Wentzel – Pathophysiology and Treatment of Long-Covid + Q&A

MORE ON COVID
The Vitamin Stack / Long Haulers Treatment

COVID-19 / SARS-CoV-2 / Novel Coronavirus

COVID-19: A Survivor’s Story

Posted on 2021/05/032023/03/07 by admin

by Daniel Brouse

(Also see the update: 3 Years of Living With It)

I am a scientist and journalist publishing articles and papers since 1994. As part of a collective of scientists, we have been working on the greatest threat to humankind — humans. Much of my effort has been spent on Anthropogenic Climate Change. In addition, I have specialized in pollution, diseases, health and wellness.

In late December 2019 and early January 2020, I started studying a novel coronavirus discovered in Wuhan, China. My first paper on the subject was published in March 2020 entitled “COVID-19 and Air Pollution”.

In late January of 2020, I had been very ill with an upper respiratory illness. The same illness killed my father. At the time, COVID-19 had not been known in the USA. Since there was no test for COVID, the doctors could not diagnose the specific virus that caused my father’s death. It wasn’t until my recurring symptoms were diagnosed as “COVID Long Haulers” in May of 2020 that I knew I was suffering the aftermath of COVID-19.

The recurring symptoms were so concerning that I devoted all of my resources to studying COVID-long and searching for a cure. Every couple of weeks I went through a wave of symptoms. Though not as severe as the original illness, the symptoms still would render me useless. The symptoms did not come on all at the same time, rather they would cycle through over two weeks (not necessarily in the same order) and then repeat. Exercise and exertion would cause the symptoms to be more severe. The symptoms included:

* difficulty breathing (feeling like you’re not taking in enough oxygen)
* congestion / mild cough
* stomach issues / diarrhea
* loss of taste, smell, and appetite
* temperature regulation / night sweats
* nightmares / vivid dreams
* dizziness / the spins / foggy thinking
* headaches / body aches / soreness
* fatigue
* ear aches
* peripheral neuropathy (tingling of the hands and feet)

My concerns were several. Would the symptoms go away over time? As the months went on, the answer was no. Would the long term recurrence of systems cause a permanent disability? The answer is probably yes. My organs were sustaining progressive damage. Respiratory, circulatory, neurological, and renal damage, as well as, blood clots, thinning and leaky blood vessels in the brain tissue, and death have all been attributed to COVID and COVID-long.

In my pursuit of answers, I found another long hauler scientist, Dr. Ade Wentzel. Ade proved to me that my hypothesis of “COVID-19 Long Haulers: autoimmune response due to inactive particles of the virus” was incorrect. Rather, he demonstrated that sars-cov-2 causes COVID-19 Induced Secondary Pellagra (CISP).

The main culprit is believed to be COVID’s genetic change to our production and utilization of NAD+ (nicotinamide adenine dinucleotide). NAD+ is involved in cell creation, maintenance, metabolism, and regulating cell processes. COVID can chronically increase the breakdown of NAD+ and simultaneously decrease the production of NAD+.

Ade added, “The biggest function of NAD+ is as a cofactor for energy(atp) production via the citric acid cycle. NAD+ is essential for carbohydrate metabolism. The brain being highly dependent on carbs.”

Ade introduced me to one of the co-authors of his research, Robert Miller. In October of 2020, Ade and Robert started me on “the stack”. The vitamin stack helps correct the NAD+ malady by treating COVID-19 Induced Secondary Pellagra. Finding the correct form and dosage of Niacin was the most challenging part.

Within days of starting the stack, my COVID-long symptoms dissipated. Since that time, I have remained relatively symptom free EXCEPT when I tried reducing the Niacin dosage. On three separate occasions, I experimented with reducing the dosage of Niacin. All three times my symptoms returned; therefore, I would call the stack a treatment not a cure.

Since that time, I have successfully helped thousands of other COVID-long victims with the stack.

At the end of April, I received my first dose of the Moderna vaccine. Loss of taste and muscle soreness symptoms returned for 24 hours and then disappeared. My overall wellness appears to have improved. Now, I’m experimenting with reducing my Niacin dosage again to see if the vaccine helped my body recover its ability to produce and retain NAD+.

After several days of reduced Niacin (nicotinic acid dosage was reduced from 300-500mg/day down to 0-30mg day), symptoms returned: neuropathy, fatigue, brain fog, muscle soreness, difficulty breathing, GI track / stomach issues, ear aches, and allergy-like symptoms. The most notable symptom to return — headaches. Prior to COVID, I did not experience headaches. Within days of decreasing the dosage, a chronic headache returned. I increased the Niacin dosage back to 500mg/day and supplemented the stack with resveratrol. Symptoms immediately dissipated.

After the second shot, side-effects were slightly worse. The metallic taste returned within a couple hours. For the 12-24 hours post-vaccination, there was dizziness, nausea, and fatigue. Then, all the side-effects disappeared. Three months after being fully vaccinated all of my presenting symptoms dissipated. Other “silent” post COVID conditions have persisted since the initial infection.

See the update: 3 Years of Living With It

CISP and The Stack

COVID-19 Induced Secondary Pellagra (CISP) and the Coronavirus Code

Posted on 2020/11/162021/07/11 by admin

By Daniel Brouse
help@membrane.com

Three scientists from South Africa have cracked the COVID code. COVID Long Haulers Syndrome is COVID Induced Secondary Pellagra (CISP).

By treating the population for pellagra:
* many new COVID cases can be prevented (prophylactic)
* the severity and duration of COVID symptoms can be reduced
* COVID-long Haulers Syndrome can be treated

THE PROTOCOL: Niacin B3, Vitamin D, Vitamin C, Quercetin, Zinc, Methyltetrahydrofolate, and Selenium.

The dosage depend on your Niacin B3 deficiency. COVID causes a Niacin deficiency. In addition, many people are deficient prior to contracting COVID. These cases often end in death (aged, hypertension, obese, and type2 diabetics.)

The following doses have treated severe niacin and NAD+ deficiencies in COVID-long cases:
* Vitamin C, Quercetin and Selenium you can get from your diet. Careful not too much Selenium. One (1) Brazil nut a day is adequate Selenium.
* The Vitamin D is best gotten from 15 minutes a day in the sun. You can take 1000iu/day supplement, too.
* A 15mg Zinc/day supplement. Care should be taken not to overdose on Zinc. There are many zinc products which deliver different amounts of free zinc per milligram.
* Methyltetrahydrofolate 130-400ug/day
* The Niacin is the trickiest and most important part. You need to make sure you get the right kind of B3. Non-flush is no good. You can start with 35mg/day, but it will depend on your deficiency. The treated long hauler takes 100-150mg with each meal. Supplementation is still necessary for an undetermined amount of time.

Niacin is the most important ingredient in the protocol. Niacin is used to replenish NAD+. The other ingredients can not be processed without NAD+. Taking mega doses of Vitamin C or Vitamin D are of little to no help without NAD+.

The protocol was developed by Dr. Ade Wentzel (Port Elizabeth, South Africa), Robert Miller (Cape Town) and Guy Richards (Johannesburg). They developed the diet based protocol as a result of their research COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity.

This is not the first time the world has seen a pellagra epidemic. “In the early 1900s, pellagra reached epidemic proportions in the American South. Between 1906 and 1940 more than 3 million Americans were affected by pellagra with more than 100,000 deaths, yet the epidemic resolved itself right after dietary niacin fortification.” (Pellagra – Wikipedia)

In 2000, the World Health Organization developed an emergency management plan for pellagra.

WHO Pellagra Prevention and Control (PDF)

COVID-19 Emergency Management Plan

Posted on 2020/11/052021/02/28 by admin

by Daniel Brouse
Email: help@membrane.com

THE COVID CRISIS
COVID-19, the SARS-CoV-2 Novel Coronavirus, is resulting in hundreds-of-thousands of deaths and millions of chronic medical conditions. A safe and effective prophylactic to prevent COVID, a treatment for active COVID cases, and a protocol for post-COVID long haulers syndrome is available. The primary ingredient is Niacin B3 and costs only pennies per day.

Research by Ade Wentzel, Robert Miller, and Guy Richards has found COVID-long (Long Haulers Syndrome) is a result of an NAD+ deficiency caused by COVID-19. [1] The protocol for treating NAD+ deficiencies has been found to be safe and effective in a study conducted on mice. [2}

THE PROTOCOL
Niacin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium

URGENT AID TO THE MOST VULNERABLE
The research proves that people with a preexisting NAD+ (nicotinamide adenine dinucleotide) deficiency are at the highest mortality risk — aged, obese and type2 diabetics. Using the Ade/Miller protocol as a prophylactic can substantially reduce mortality in the predisposed.

THE GENERAL POPULATION
The public at large can also benefit from the protocol. The severity and duration of COVID-19 symptoms can be greatly minimized by maintaining NAD+ in the body. Symptoms of long haulers can be treated and cured.

THE SYMPTOMS
NAD+ is involved in cell creation, maintenance, metabolism, and regulating cell processes. COVID both increases the breakdown of NAD+ and decreases the production of NAD+.

Symptoms of a NAD+ deficiency may include:
* difficulty breathing (feeling like you’re not taking in enough oxygen)
* congestion / cough
* stomach issues / nausea / diarrhea
* loss of taste, smell, and appetite
* body temperature regulation, fever, night sweats, chills
* nightmares / vivid dreams
* brain fog / dizziness / the spins
* headaches / body aches / soreness
* fatigue
* ear aches
* skin lesions
* anxiety or depression

The protocol addresses all these ailments. A niacin supplement is the cheapest and safest treatment.

PELLAGRA
A niacin deficiency results in pellagra. Emergency plans for treating pellagra have already been developed in both the United States and worldwide. Long haulers syndrome is COVID-19 Induced Secondary Pellagra (CISP).

Pellagra was first identified among Spanish peasants by Don Gaspar Casal in 1735. Pellagra has sometimes been called the disease of the four D’s – dermatitis, diarrhoea, dementia, and death. [3] Pellagra was in existence for nearly two centuries in Europe before being recognized in the United States, where it was first reported in 1902. Over the next two decades, pellagra occurred in epidemic proportions in the American South. [4] By the time of the Mississippi flood in 1927, Dr Joseph Goldberger of the USPHS had conducted extensive research demonstrating that pellagra was caused by a nutritional deficiency (a lack of niacin, or vitamin B3). Goldberger advised the Red Cross to add brewer’s yeast to its food rations. Within weeks, people with pellagra were cured, and new cases of pellagra were prevented. [5]

WORLD EMERGENCY MANAGEMENT PLAN
In 2000, the World Health Organization developed an emergency management plan for pellagra.

WHO Pellagra Prevention and Control (PDF)

Cases of pellagra “responded dramatically both to nicotinic acid.” Because several forms of niacin are available to the body, and tryptophan can be converted to niacinat the ratio of 60 mg of tryptophan to 1 mg niacin, the term “niacin equivalent” is used to describe the contribution to dietary intake of all active forms of niacin. Niacin is a member of the B-vitamin complex group.

CONCLUSION
A large quantity and quality of lives could be saved by implementing the protocol of Niacin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium.

1. COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity Wentzel, Miller, Richards
COVID-19: NAD+ Deficiency by Wentzel, Miller, Richards (PDF)

2. Treatment of SARS-CoV-2 induced pneumonia with NAD+ in a mouse model Jiang, Deng, Ma, Pang, Hu, Qin, Xu
COVID-19 in Mice / NAD+ (PDF)

3. Joseph Goldberger’s research on the prevention of pellagra Alfredo Morabia

4. Pellagra in the United States: a historical perspective NIH

5. Preventing Chronic Diseases CDC

Tag: Post Acute Sequelae of SARS-CoV-2 (PASC)

COVID Vaccine Breakthrough Cases

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

COVID-19 Delta Variant and Vaccines

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

Post-Acute COVID-19 — COVID Long Haulers Syndrome

COVID-19: A Survivor’s Story

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

COVID-19 Induced Secondary Pellagra (CISP) and the Coronavirus Code

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

COVID-19 Emergency Management Plan