COVID-19 causes DNA damage. “DNA damage-mediated PARP activation is the cause of NAD+ depletion. The PARP1 inhibitor ABT-888 prevents the increase in PAR levels, NAD+ depletion and CaT loss. These findings confirm that DNA damage-mediated PARP activation is the cause of NAD+ depletion.
PARP1-mediated synthesis of ADP-ribose chains in turn depletes nicotinamide adenine dinucleotide (NAD+), induces further DNA damage and contractile dysfunction. Accordingly, NAD+ replenishment or PARP1 depletion precludes functional loss. Moreover, inhibition of PARP1 protects against tachypacing-induced NAD+ depletion, oxidative stress, DNA damage. [1]
COVID-long Haulers Syndrome is COVID-19 Induced Secondary Pellagra (CISP). NAD+ depletion causes the body to take drastic action to create more NAD+ including depleting niacin and tryptophan. Exercise or exertion results in PARP activation causing low NAD+. The exertion will cause cardiac problems from the nutritional deficiency and low serotonin from the use of tryptophan will cause problems with your metabolic regulation. Night sweats, intestinal upset, anxiety, and other symptoms are common.
COVID-19: NAD+ Protocol
NAD+ is a crucial part of the immune system. COVID depletes your NAD+. The body needs the time and materials necessary to replenish NAD+. Included in the elements you need are Niacin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium.