by Daniel Brouse
help@membrane.com
Exercise aggravates long-COVID symptoms. COVID causes changes to your genes making it harder to create NAD+ and quicker to consume NAD+. Normally, exercise helps boost your NAD+. Not with long-COVID. The inflammation caused by exercise, anxiety, or exertion causes a rapid depletion of NAD+ aggravating long-COVID symptoms and perpetuating the downward cycle in NAD+ levels. So, Long Haulers should limit their activity until their NAD+ deficiency is under control.
What other factors can impact the severity of your long-COVID symptoms? We know anything that depletes NAD+ will cause problems. Aging, Hypertension, Obesity, Type 2 Diabetes, and other ailments result in suboptimal NAD+. But, what about your environment?
We know long term exposure to air pollution increases the risk of death from COVID-19 by 20 times. Another reason why wearing a mask in the out-of-doors is a good idea. Completely avoid outside exposure on air quality alert days.
I have been conducting research and development on two other environmental factors — elevation and temperature.
ELEVATION I — Change in Atmospheric Pressure
Elevation is the number of feet above sea level on which you stand. The bio-hacker experiment I’ve been conducting takes me from 400 feet above sea level to 1,400 feet above sea level. The more rapid the change from higher elevations to lower elevation, then the worse my long-COVID symptoms. All systems feel an impact; however, the middle ear takes the brunt of the punishment. Brain fog, dizziness, tinnitus, ear aches, vertigo, and pressure in the ears are all amplified in their severity. I just did a 24 hour experiment and am beginning to think it has to do with pressure. Perhaps O2 (oxygen in the blood) as well, but more to do with “atmospheric pressure and sea level.” The symptoms seem to lag behind the increase in pressure.
Dr. Ade Wentzel said, “The epigenetic upregulation of IDO will determine the amount of quinolinic acid. Quinolinic acid comes from the kynurenine pathway. If the viscosity of the whole middle ear is increased then the ability to equalize will be less… same as having a cold. So, the ear isn’t equalizing correctly on increasing pressure. The same as when you land in a plane. If the viscosity in the semicircular canals is increased, the otoliths may well be lagging causing the vertigo. The otoliths usually “Float” in the semicircular canal and trigger tiny sensory hairs that allow you to detect position.”
“IDO (Indoleamine 2,3-dioxygenase) is an immune checkpoint molecule in the sense that it is an immunomodulatory enzyme produced by alternatively activated macrophages and other immunoregulatory cells. IDO is known to suppress T and NK cells, generate Tregs and myeloid-derived suppressor cells, and also supports angiogenesis.’ (Wikipedia)
It is possible that changes in the weather that cause changes in atmospheric pressure (Lows and Highs) may result in the same problems. This happened to me with weather systems over the weekend (August 22, 2021.) A very low pressure system (hurricane Henri) passed by followed by a high pressure system. The following 2 days I suffered from brain fog, dizziness, tinnitus, ear aches, vertigo, and pressure in the ears.
ELEVATION II — Oxygen Desaturation
People that go to higher elevations — above 4,900 feet — start to have more problems with High Altitude Oxygenation. “High altitudes can cause low oxygen saturation levels or desaturation of an individual’s blood.” Changing elevations at higher than 4,900 feet might cause both oxygen desaturation and atmospheric pressure problems.
COVID causes a decrease in the “rate of oxygen uptake into the lung to the oxygen gradient between the capillary blood and the alveoli.” Dr. Ade Wentzel said, “We know that the Lung Diffusion co-efficient is increased [by optimizing NAD+ levels].”
TEMPERATURE
The sweet spot is between 50-70 degrees Fahrenheit. The further below 50 degrees the more severe the symptoms. Lower temperatures appear to be a linear relationship. On the other hand, temperatures above 70 degrees appear to have an exponential relationship. That is to say, if 80 degrees causes symptoms to be twice as bad, 90 degrees causes symptoms to be four times as severe.
CONCLUSION
Mountain hiking in 90 degree temperatures (exercise at higher elevations in the heat) causes unnecessary stress on your system and dramatically increases your chances of a negative outcome.