When the COVID-19 genome changes, it is called a mutation. When the mutations combine, it is called a variant. When variants combine, it is called a recombination.
The general consensus is SARS-CoV-2 originated from a recombination event. An animal variant combines with a human variant and jumps to humans. When a virus jumps form animals to humans, it is called zoonotic. It is feared recombination events could make SARTS-CoV-2 endemic jumping back and forth between animals and humans.
“Two variants of the SARS-CoV-2 coronavirus that causes covid-19 have combined their genomes to form a heavily mutated hybrid version of the virus. The “recombination” event was discovered in a virus sample in California, provoking warnings that we may be poised to enter a new phase of the pandemic.
The hybrid virus is the result of recombination of the highly transmissible B.1.1.7 variant discovered in the UK and the B.1.429 variant that originated in California and which may be responsible for a recent wave of cases in Los Angeles because it carries a mutation making it resistant to some antibodies,” as reported in NewScientist.
“We may be getting to the point when this is happening at appreciable rates,” says Sergei Pond at Temple University in Pennsylvania, who keeps an eye out for recombinants by comparing thousands of genome sequences uploaded to databases. He says there is still no evidence of widespread recombination, but that “coronaviruses all recombine, so it’s a question of when, not if”.