By Daniel Brouse
Vitamin B3 / Niacin / Nicotinic Acid
Attn: Long Haulers focus on supplementing with nicotinic acid.
A research paper co-authored by Ade Wentzel found, “The SARS-CoV-2 hyperinflammatory response is associated with high mortality.” In essence, COVID-19 ‘eats’ the immune system’s NAD+ (nicotinamide adenine dinucleotide) and restricts your ability to make more. NAD+ is one of the most critical pieces to your immune system puzzle. A deficiency in NAD+ needs to be corrected over time by allowing the body to produce a new supply of NAD+. Nicotinic acid can help reduce the severity of COVID-19, as well as, treat long-COVID long haulers syndrome. Nicotinic acid is also the most important supplement to prevent aging, hypertension, type II diabetes, and obesity NAD+ deficiencies.
NAD+ is nicotinamide adenine dinucleotide. The formula to create NAD+ is complicated (see diagram below). The simplest way to explain it is: add Vitamin B3 Niacin (nicotinic acid) to your diet. Ade suggests, ‘You can take nicotinic acid orally or niagen (if you have deep pockets). However you supplement, you need to keep going for at least a good few months.”
Ade added, “I’d rather use nicotinic acid and not nicotinamide, as the latter can be a SIRT1 inhibitor.
Nicotinic acid is also probably the most direct way to save tryptophan.
There is no need to limit nicotinic acid to 35mg.
It has been used in lipid trials up to 3000mg a day (44mg/kg body weight)”
I have to take 150mg of nicotinic acid with each meal (3 times per day) to treat my long-COVID “long haulers syndrome”. To save money, I buy 500mg tablets and break them into pieces. It costs me about 3 cents per day to treat my NAD+ deficiency.
“When you dig down deep enough it’s amazing how often you end up at NAD+,” added Robert Miller, another co-author of COVID-19: NAD+ deficiency.
Vitamin B3 / niacin is the most crucial component for creating NAD+; however, you also need to be concerned about Vitamins C, D, Quercetin, Zinc, Methyltetrahydrofolate, and Selenium. All of these elements need to be considered both on their own merits, as well as, combined with the others. Vitamin D is particularly complex and should be part of a well thought out plan. If brain fog makes this too complicated, start with the nicotinic acid. Lack of nicotinic acid causes your body to hi-jack tryptophan and all hell breaks loose. Focus on supplementing with nicotinic acid.
Ade asked, “My American bread check didn’t show Niacin fortification?”
I replied, “Unfortunately, most Americans get their Niacin from fortified breakfast cereal.” They spray Niacin on the outside with several other vitamins. It would take 100 bowls of Wheaties/day to correct a niacin deficiency (not recommended).
Robert added, “17.5mg nicotinic acid per 100g of Kellogg’s cereal BUT this isn’t enough given the destructive diet of many of those eating the cereal. Continually hyperglycaemia like you would expect from the sugar in the cereal drives up CD38 and drives down NAD+ meaning you would need substantially more nicotinic acid. We are seriously beginning to suspect that many people actually have pseudo pellegra which is not easy to diagnose. However low Vitamin D levels and plasma tryptophan could be a good indicator of this as well as your risk from Covid-19.”
I replied, “The problem in the USA is… it is difficult to get prescribed Nicotinic Acid… and I have not been able to find it over-the-counter. Doctors and insurance companies don’t cover it. I have been trying to increase my dietary intake, as well as, taking a Inositol Nicotinate supplement.”
Robert offered, “Avoid Inositol Nicotinate (non-flushing B3 Niacin).”
Ade added, “We suggest you use nicotinic acid (niacin B3). We also believe it works most directly to increase NAD+. Niacin doesn’t cause liver problems. Non-flush niacin does though.”
After searching, I said, “It is surprisingly hard to find at a drug store. Neither CVS nor Walgreens carry it. I think I found it at Rite Aid. I’ll try to buy some today. If not, I’ll have to order it online.”
Robert explained, “The problem is that nicotininc acid costs around $15 per kg, so the nicotinic acid in bottle of 90 35mg tablets costs $0.047 . There is no money in it so big pharma isn’t interested in it.”
Finally, I found it, “If anybody is looking to get Niacin, I found it at Rite Aid… currently buy 1 get one free… confirmed with the pharmacist that it is the correct type.”
DOSAGE
WARNING: Niacin may cause flushing. Niacin flush is a common side effect of taking niacin supplements. It appears as red flushing skin, and may be accompanied by itching or burning. It usually lasts under 15 minutes. In almost all cases, flushing is not harmful. [If you have a severe flushing experience and are freaking-out, ingest apples or apple juice (pectin).] Start with 20mg consumed with a meal. Increase to 50mg with each meal. Keep increasing your daily dosage until you stop flushing. That is how you know the proper dosage for you. The more deficient you are the worse the flushing. If you do not flush the first time, you probably are not taking the right type of B3 Niacin. Some people prefer to smash it up and dissolve the dosage in a drink or mix it into their food.
Niacin may aggravate some medical conditions. You should consult your doctor prior to taking Niacin. Your doctor may prescribe higher does to help correct an NAD+ deficiency.
A complete NAD+ immune boosting diet.
Niacin / Vitamin B3
Niacin Label
B3, Niacin, COVID, and NAD+
COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity R.Millerc, A.R.Wentzel, G.A.Richards